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LSN 3318839

Catalog #: 7959 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7959/5
LSN 3318839 | CAS No. 2764704-18-7 | Glucagon-Like Peptide 1 Receptor Modulators
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Description: Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator

Chemical Name: (R)-2-(2-(1-((R)-1-(2,6-Dichloro-3-cyclopropylphenyl)ethyl)-1H-imidazo[4,5-c]pyridin-6-yl)phenyl)propanoic acid

Purity: ≥98%

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Biological Activity

LSN 3318839 is a potent glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator (EC50 = 14 nM). Acts as a molecular glue to stabilize peptide ligand and GLP1 receptor interaction. Potentiates activity of GLP-1 (7-36) (Cat. No. 2082) and the low-affinity metabolite GLP-1 (9-36) (Cat. No. 3266). LSN 3318839 alone or in combination with Sitagliptin (Cat. No. 6816) lowers glucose levels in animal models of diabetes. LSN 3318839 is orally bioavailable.

Technical Data

M.Wt:
480.39
Formula:
C26H23Cl2N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2764704-18-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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