Glucagon-like peptide 1 (7-36) amide (human, rat)

Biological Activity

Glucagon-like peptide 1 (7-36) amide (human, rat) is a potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (K_d = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Receptors for glucagon-like peptide-1(7-37) amide on rat Insoma-derived cells.
   Goke and Conlon
   J.Endocrinol., 1988;116:357
2. A role for glucagon-like peptide-1 in the central regulation of feeding.
   Turton et al.
   Nature, 1996;379:69
3. Glucagon-like peptide-1: a major regulator of pancreatic β-cell function.
   Perfetti and Merkel
   Eur.J.Endocrinol., 2000;143:717
4. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
   Perry et al.
   J.Pharmacol.Exp.Ther., 2002;302:881

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