LY 379268
1 Image
Description: Highly selective group II mGlu agonist
Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Purity: ≥99%
Biological Activity
LY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. LY379268 disodium salt also available.Technical Data
M.Wt:
187.15
Formula:
C7H9NO5
Solubility:
Soluble to 20 mM in water and to 100 mM in 1eq. NaOH
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
191471-52-0
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under license from Eli Lilly and Company
Background References
-
LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia.
Bond et al.
Neurosci.Lett., 1999;273 -
Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo.
Bond et al.
J.Pharmacol.Exp.Ther., 2000;294:800 -
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties.
Collado et al.
J.Med.Chem., 2002;45:3619
Product Datasheets
Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator
Reconstitution Calculator
Molarity Calculator
Citations for LY 379268
The citations listed below are publications that use Tocris products. Selected citations for LY 379268 include:
19 Citations: Showing 1 - 10
-
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
Authors: Scholler
Nat Commun 2017;8(1):1967
-
mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.
Authors: Chandrasekaran Et al.
Ann Clin Transl Neurol 2017;4:844
-
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Authors: Scholler
Nat Chem Biol 2017;13(4):372
-
Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum.
Authors: Johnson
Neuropharmacology 2017;117:114
-
The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
Authors: Carbonaro Et al.
J Neurosci 2015;232:275
-
The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation.
Authors: Erlandson Et al.
Psychopharmacology (Berl) 2015;10:e0132008
-
Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
Authors: Wang Et al.
PLoS One 2013;8:e61787
-
Group II metabotropic glutamate receptors modify N-MthD.-aspartate receptors via Src kinase.
Authors: Trepanier Et al.
Sci Rep 2013;3:926
-
Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury.
Authors: Hinzman Et al.
J Neurotrauma 2012;29:1197
-
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A-mGlu2) receptor heteromerization and its psychoactive behavioral function.
Authors: Moreno Et al.
Front Mol Neurosci 2012;287:44301
-
Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.
Authors: Vinkers Et al.
Psychopharmacology (Berl) 2012;219:897
-
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
-
Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes.
Authors: Durand Et al.
PLoS One 2011;6:e22235
-
mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum.
Authors: Liberto Et al.
Neuropharmacology 2011;61:638
-
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring.
Authors: Moreno Et al.
J Biol Chem 2011;31:1863
-
The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.
Authors: Bellesi and Conti
Neuropsychopharmacology 2010;35:1253
-
Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses DA depletion-induced dendritic spine loss.
Authors: Garcia Et al.
Cereb Cortex 2010;20:2423
-
The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
Authors: Chen Et al.
Psychopharmacology (Berl) 2010;209:343
-
A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
Authors: Sekizawa Et al.
J Neurosci 2009;29:11807
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for LY 379268
There are currently no reviews for this product. Be the first to review LY 379268 and earn rewards!
Have you used LY 379268?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive
tools for
life science research with over 30 years' experience in the
industry.
Tocris is a Bio-Techne brand.
