LY 379268 disodium salt
Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid disodium salt
Purity: ≥98%
Biological Activity
LY 379268 disodium salt is a sodium salt of LY 379268 (Cat. No. 2453), a highly selective group II mGlu receptor agonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia.
Bond et al.
Neurosci.Lett., 1999;273 -
Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo.
Bond et al.
J.Pharmacol.Exp.Ther., 2000;294:800 -
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties.
Collado et al.
J.Med.Chem., 2002;45:3619
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Citations for LY 379268 disodium salt
The citations listed below are publications that use Tocris products. Selected citations for LY 379268 disodium salt include:
2 Citations: Showing 1 - 2
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Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
Authors: Craig W Et al.
Biol Psychiatry 2021;90:385-398
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Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells.
Authors: Javier Et al.
Cell Chem Biol 2020;27:1308-1317.e4
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