Mouse CEACAM-1/CD66a APC-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CEACAM-1/CD66a

CEACAM-1 (Carcinoembryonic Antigen-related Cell Adhesion Molecule 1), also known as BGP-1, CD66a and MHVR1, is a 110-120 kDa member of the CEACAM subfamily, CEA family of proteins. It has a wide expression pattern, being found on neutrophils, dendritic cells, endothelial cells, colonic epithelium and hepatocytes. It mediates cell adhesion, and appears to regulate insulin levels and signaling by interacting with the insulin receptor. It also demonstrates proangiogenic effects by inducing endothelial cells to proliferate and form capillary-like tubules. Finally, CEACAM-1 is a known receptor for mouse hepatitis virus. Mature mouse CEACAM-1 is a 487 amino acid (aa) type I transmembrane glycoprotein. Its contains a 394 aa extracellular region (aa 35-428) that shows one V-type (aa 35-142) and three C2-type (aa 147-411) Ig-like domains, plus a 74 aa cytoplasmic domain. Three alternate splice forms exist. One contains a four aa substitution for aa 455-521, a second shows a Gln substitution for aa 142-322, and a third possesses a combination of the first two splice patterns. CEACAM-1 forms homodimers. Over aa 35-428, mouse CEACAM-1 shares 56% and 70% aa identity with human and rat CEACAM-1, respectively.

Product Datasheets

Related Research Areas

• Adhesion Molecules in Angiogenesis
• Cancer Biomarkers
• Epithelial Cell Markers and Intracellular Molecules
• Granulocyte Markers
• Immunoglobulin Superfamily CAMs
• ITIM/ITAM Immunoreceptors and Related Molecules
• Myeloid Lineage Markers
• Platelet Adhesion Molecules
• Search Immune Checkpoint Targets
• Surface Ectodermal Cells