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Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit

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Mouse/Rat IGF-I ELISA Standard Curve
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Summary Sample Values Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (25 uL), Tissue Homogenates (50 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL)
Sensitivity
8.4 pg/mL
Assay Range
31.2 - 2,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma)
Specificity
Natural and recombinant mouse and rat IGF-I
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Sample Values

Serum/Plasma - Individual mouse and rat serum and plasma samples were evaluated for detectable levels of mouse and rat IGF-1 in this assay. Serum and plasma samples were not matched.

Sample TypeMean (ng/mL)Range (ng/mL)Standard Deviation (ng/mL)
Mouse serum (n=20)742513-924113
Mouse EDTA plasma (n=20)593346-806130
Mouse heparin plasma (n=20)821542-1447203

Sample TypeMean (ng/mL)Range (ng/mL)Standard Deviation (ng/mL)
Rat serum (n=20)1158436-1908376
Rat EDTA plasma (n=20)1016430-2207377
Rat heparin plasma (n=20)1012723-1444208

Cell Culture Supernates:
J774A.1 mouse reticulum cell sarcoma macrophage cells (1 x 106 cells/mL) were cultured for 3 days in DMEM containing 10% fetal bovine serum and stimulated with 2.5 ng/mL LPS. The cell culture supernate was assayed for mouse IGF-1 and measured 5842 pg/mL.

WEHI-3 mouse myelomonocytic leukemia cells were cultured for 2-4 days in RPMI supplemented with 10% fetal bovine serum. The cell culture supernate was assayed for mouse IGF-1 and measured 4944 pg/mL.

Rat lung conditioned media (1 lung, 1-2 mm pieces) was cultured for 2 days in 50 mL of DMEM supplemented with 10% fetal bovine serum and stimulated with 100 ng/mL LPS and 50 ng/mL PMA. The cell culture supernate was assayed for rat IGF-1 and measured 1514 pg/mL.

Rat heart conditioned media (1 heart, 1-2 mm pieces) was cultured for 4 days in 30 mL of RPMI, supplemented with 10% fetal bovine serum, and stimulated with 2.5 ng/mL LPS. The cell culture supernate was assayed for rat IGF-1 and measured 2888 pg/mL.

Tissue Homogenates:
Homogenates from mouse lung and mouse heart tissue were assayed for levels of mouse IGF-1 and measured 5862 pg/mL and 3158 pg/mL, respectively. 
Homogenates from rat lung and rat heart tissue were assayed for levels of rat IGF-1 and measured 5476 pg/mL and 1785 pg/mL, respectively.


Product Summary

The Quantikine Mouse/Rat IGF-I Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse and rat IGF-I in cell culture supernates, tissue homogenates, serum, and plasma. It contains E. coli-expressed recombinant mouse IGF-I and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse and rat IGF-I showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse/rat IGF-I.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3
n 20 20 35
Mean (pg/mL) 82 269 863
Standard Deviation 4.6 8.9 37.4
CV% 5.6 3.3 4.3

Recovery

The recovery of mouse/rat IGF-I spiked to three levels throughout the range of the assay in the cell culture supernate samples was evaluated.

Sample Type Average % Recovery Range %
Mouse Cell Culture Supernates (n=7) 98 89-111
Rat Cell Culture Supernates (n=6) 98 82-108

Linearity

To assess the linearity of the assay, samples containing mouse or rat IGF-I in each matrix were diluted with Calibrator Diluent and then assayed.
Mouse/Rat IGF-I ELISA Linearity
Mouse/Rat IGF-I ELISA Linearity

Scientific Data

N/A Mouse/Rat IGF-I ELISA Standard Curve View Larger

Mouse/Rat IGF-I ELISA Standard Curve

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IGF-I/IGF-1

Insulin-like Growth Factor 1 (IGF-1), also known as somatomedin C, is a member of the insulin superfamily. It was originally discovered as a mediator of growth hormone actions on somatic cell growth, but has also been shown to be an important regulator of cell metabolism, differentiation and survival. IGF-1 is synthesized as a preproprotein that is proteolytically cleaved to generate the mature protein linked by three disulfide bonds. Mature IGF-1 is highly conserved among large mammals, with 100% sequence identity between the human, bovine, porcine, equine, and canine proteins. 


Mature mouse IGF-1 is a non-glycosylated, 70 amino acid (aa) secreted polypeptide that is derived from either a 153 aa or a 159 aa preproprotein. It shares 99% and 94% aa sequence identity with rat and human IGF-1, respectively. IGF-1 is synthesized in the liver and other tissues. It is found in blood and other body fluids as a complex with specific high affinity IGF binding proteins (IGFBP-1 to -6). The IGFBPs are expressed in specific patterns during development. They are modulators of IGF actions, which control IGF bioavailability to specific cell-surface receptors. Their functions are further regulated by IGFBP proteases, which proteolytically cleave the IGFBPs to lower the affinity with which they bind IGFs and increase IGF bioavailability. Some IGFBPs also have IGF-Independent effects on cell functions. IGF-Independent circulates primarily as a ternary complex with IGFBP-3 or IGFBP-5 and the acid-labile subunit (ALS). Some IGF-1 is also present in binary complexes with other IGFBPs. Whereas the ternary complexes are generally restricted to the vasculature, the binary complexes freely enter the tissues. 

IGF-1 actions are mediated by two ubiquitously expressed receptor tyrosine kinases: IGF-I R and Insulin R/CD220. IGF-I R and Insulin R are disulfide-linked heterotetrameric complexes that consist of two alpha and two beta subunits. For both of these receptors, the prepro proteins are cleaved to produce extracellular alpha subunits which contain a cysteine-rich region and ligand-binding fibronectin type III (FN-III) domains, and beta subunits which contain an extracellular FN-III domain, transmembrane, and cytoplasmic tyrosine kinase domains. A hybrid complex containing one IGF-I R and one Insulin R also serves as a functional high affinity receptor for IGF-1. IGF-I R-Insulin R hybrids respond primarily to IGF-1, potentially downregulating the cellular response to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-I I R.

Long Name:
Insulin-like Growth Factor I/Insulin-like Growth Factor 1
Entrez Gene IDs:
3479 (Human); 16000 (Mouse); 24482 (Rat)
Alternate Names:
IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 50 µL Assay Diluent
  3.   Add 50 µL of Assay Diluent to each well.
    4. 50 µL Standard, Control, or Sample
  4.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours on a horizontal orbital microplate shaker.
  5.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.
    6. 100 µL Conjugate
  6.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours on the shaker.
  7.   Aspirate and wash 5 times.
    8. 100 µL Substrate Solution
  8.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes on the benchtop. PROTECT FROM LIGHT.
    9. 100 µL Stop Solution
  9.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

179 Citations: Showing 1 - 10
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  1. Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system
    Authors: Walser, M;Karlsson, L;Motalleb, R;Isgaard, J;Kuhn, HG;Svensson, J;Åberg, ND;
    Scientific reports
    Species: Mouse
    Sample Types: Plasma
  2. Trem2-deficiency aggravates and accelerates age-related myelin degeneration
    Authors: McCray, TJ;Bedford, LM;Bissel, SJ;Lamb, BT;
    Acta neuropathologica communications
    Species: Mouse
    Sample Types: Tissue Homogenates
  3. Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice
    Authors: Sandovici, I;Fernandez-Twinn, DS;Campbell, N;Cooper, WN;Sekita, Y;Zvetkova, I;Ferland-McCollough, D;Prosser, HM;Oyama, LM;Pantaleão, LC;Cimadomo, D;Barbosa de Queiroz, K;Cheuk, CSK;Smith, NM;Kay, RG;Antrobus, R;Hoelle, K;Ma, MKL;Smith, NH;Geyer, SH;Reissig, LF;Weninger, WJ;Siddle, K;Willis, AE;Lam, BYH;Bushell, M;Ozanne, SE;Constância, M;
    Cell reports
    Species: Mouse, Transgenic Mouse
    Sample Types: Serum, Plasma, Tissue Homogenates
  4. A vascular endothelial growth factor-loaded chitosanhyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke
    Authors: Zheng, Z;Lin, X;Zhao, Z;Lin, Q;Liu, J;Chen, M;Wu, W;Wu, Z;Liu, N;Chen, H;
    Neural regeneration research
    Species: Rat
    Sample Types: Cell Culture Supernates
  5. Distinct, common and synergistic effects of insulin and IGF-1 receptors on healthy murine ageing
    Authors: Walker, AM;Watt, NT;Yuldasheva, NY;Dalmia, S;Conning-Rowland, M;Cheng, CW;Warmke, N;Bridge, K;Brown, OI;Luk, C;Drozd, M;Haywood, NJ;Skromna, A;Makava, N;Wheatcroft, SB;Kearney, MT;Cubbon, RM;
    Heliyon
    Species: Mouse
    Sample Types: Serum
  6. TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice
    Authors: Tresky, R;Miyamoto, Y;Nagayoshi, Y;Yabuki, Y;Araki, K;Takahashi, Y;Komohara, Y;Ge, H;Nishiguchi, K;Fukuda, T;Kaneko, H;Maeda, N;Matsuura, J;Iwasaki, S;Sakakida, K;Shioda, N;Wei, FY;Tomizawa, K;Chujo, T;
    Nucleic acids research
    Species: Transgenic Mouse
    Sample Types: Serum
  7. Developmental fluoxetine exposure affects adolescent and adult bone depending on the dose and period of exposure in mice
    Authors: Fricke, HP;Krajco, CJ;Perry, MJ;Desorcy-Scherer, KM;Wake, LA;Charles, JF;Hernandez, LL;
    Physiological reports
    Species: Mouse
    Sample Types: Serum
  8. The secretome atlas of two mouse models of progeria
    Authors: Quintana-Torres, D;Valle-Cao, A;Bousquets-Muñoz, P;Freitas-Rodríguez, S;Rodríguez, F;Lucia, A;López-Otín, C;López-Soto, A;Folgueras, AR;
    Aging cell
    Species: Mouse
    Sample Types: Plasma
  9. Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors
    Authors: Tu, X;Jain, A;Parra Bueno, P;Decker, H;Liu, X;Yasuda, R;
    Science advances
    Species: Mouse
    Sample Types: Cell Culture Supernatants
  10. Phosphorylation of AMPK? at Ser485/491 Is Dependent on Muscle Contraction and Not Muscle-Specific IGF-I Overexpression
    Authors: Chou, CH;Barton, ER;
    International journal of molecular sciences
    Species: Mouse
    Sample Types: Tissue Homogenates
  11. Delayed skeletal development and IGF-1 deficiency in a mouse model of lysinuric protein intolerance
    Authors: Stroup, BM;Li, X;Ho, S;Zhouyao, H;Chen, Y;Ani, S;Dawson, B;Jin, Z;Marom, R;Jiang, MM;Lorenzo, I;Rosen, D;Lanza, D;Aceves, N;Koh, S;Seavitt, JR;Heaney, JD;Lee, B;Burrage, LC;
    Disease models & mechanisms
    Species: Mouse
    Sample Types: Plasma
  12. The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix
    Authors: O'Brien, JG;Willis, AB;Long, AM;Kwon, J;Lee, G;Li, F;Page, PGT;Vo, AH;Hadhazy, M;Crosbie, RH;Demonbreun, AR;McNally, EM;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Serum
  13. Alterations in gonadotropin, apoptotic and metabolic pathways in granulosa cells warrant superior fertility of the Dummerstorf high fertility mouse line 1
    Authors: CLM Ludwig, S Bohleber, R Lapp, A Rebl, EK Wirth, M Langhammer, U Schweizer, JM Weitzel, M Michaelis
    Journal of ovarian research, 2023-02-04;16(1):32.
    Species: Mouse
    Sample Types: Serum
  14. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups
    Authors: T Hirabayash, M Kawaguchi, S Harada, M Mouri, R Takamiya, Y Miki, H Sato, Y Taketomi, K Yokoyama, T Kobayashi, SM Tokuoka, Y Kita, E Yoda, S Hara, K Mikami, Y Nishito, N Kikuchi, R Nakata, M Kaneko, H Kiyonari, K Kasahara, T Aiba, K Ikeda, T Soga, M Kurano, Y Yatomi, M Murakami
    Cell Reports, 2023-01-30;42(2):111940.
    Species: Mouse
    Sample Types: Serum
  15. MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair
    Authors: X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard
    International Journal of Molecular Sciences, 2023-01-25;24(3):.
    Species: Mouse
    Sample Types: Serum
  16. Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production
    Authors: K Yamanaka, Y Haraguchi, H Takahashi, I Kawashima, T Shimizu
    Scientific Reports, 2023-01-10;13(1):498.
    Species: Bovine
    Sample Types: Cell Culture Supernates
  17. GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia
    Authors: JY Kim-Muller, L Song, B LaCarubba, E Pashos, X Li, A Rinaldi, S Joaquim, JC Stansfield, J Zhang, A Robertson, J Pang, A Opsahl, M Boucher, D Breen, K Hales, A Sheikh, Z Wu, BB Zhang
    Cell Reports, 2023-01-10;42(1):111947.
    Species: Mouse
    Sample Types: Plasma
  18. MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair
    Authors: X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard
    International Journal of Molecular Sciences, 2023;24(3):.
    Species: Mouse
    Sample Types: Serum
  19. Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton
    Authors: J Wang, Q Zhu, D Cao, Q Peng, X Zhang, C Li, C Zhang, BO Zhou, R Yue
    Proceedings of the National Academy of Sciences of the United States of America, 2022-12-28;120(1):e2203779120.
    Species: Mouse
    Sample Types: Plasma
  20. Stereological Evidence of Non-Selective Hippocampal Neurodegeneration, IGF-1 Depletion, and Behavioral Deficit following Short Term Bilateral Adrenalectomy in Wistar Rats
    Authors: N Hamadi, ÖG Deniz, ASA Issa, AUS Islam, N Amir, ST Minhas, N Madjid, F Khelifi-To, S Kaplan, A Adem
    Biomolecules, 2022-12-22;13(1):.
    Species: Rat
    Sample Types: Tissue Homogenates
  21. Transcriptome and Methylome Profiling in Rat Skeletal Muscle: Impact of Post-Weaning Protein Restriction
    Authors: S Ma, E Hasegawa, Y Nakai, H Jia, H Kato
    International Journal of Molecular Sciences, 2022-12-12;23(24):.
    Species: Rat
    Sample Types: Serum
  22. Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy
    Authors: Z Liu, H Shi, J Xu, Q Yang, Q Ma, X Mao, Z Xu, Y Zhou, Q Da, Y Cai, DJ Fulton, Z Dong, A Sodhi, RB Caldwell, Y Huo
    JCI Insight, 2022-12-08;7(23):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  23. Bone loss is ameliorated by fecal microbiota transplantation through SCFA/GPR41/ IGF1 pathway in sickle cell disease mice
    Authors: L Xiao, Y Zhou, S Bokoliya, Q Lin, M Hurley
    Scientific Reports, 2022-11-30;12(1):20638.
    Species: Mouse
    Sample Types: Serum
  24. Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis
    Authors: A Hiroto, WK Kim, A Pineda, Y He, DH Lee, V Le, AW Olson, J Aldahl, CH Nenninger, AJ Buckley, GQ Xiao, J Geradts, Z Sun
    Nature Communications, 2022-11-02;13(1):6552.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  25. Glia from the central and peripheral nervous system are differentially affected by paclitaxel chemotherapy via modulating their neuroinflammatory and neuroregenerative properties
    Authors: I Klein, J Boenert, F Lange, B Christense, MK Wassermann, MHJ Wiesen, DN Olschewski, M Rabenstein, C Müller, HC Lehmann, GR Fink, M Schroeter, MA Rueger, SU Vay
    Frontiers in Pharmacology, 2022-11-02;13(0):1038285.
    Species: Rat
    Sample Types: Cell Culture Supernates
  26. LIF-IGF Axis Contributes to the Proliferation of Neural Progenitor Cells in Developing Rat Cerebrum
    Authors: S Takata, H Sakata-Hag, H Shimada, T Tsukada, D Sakai, H Shoji, M Tomosugi, Y Nakamura, Y Ishigaki, H Iizuka, Y Hayashi, T Hatta
    International Journal of Molecular Sciences, 2022-10-30;23(21):.
    Species: Mouse
    Sample Types: Serum
  27. MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis
    Authors: MP LaPierre, K Lawler, S Godbersen, IS Farooqi, M Stoffel
    Nature Communications, 2022-09-29;13(1):5733.
    Species: Mouse
    Sample Types: Tissue Homogenates
  28. Global Proteome Profiling of the Temporal Cortex of Female Rats Exposed to Chronic Stress and the Western Diet
    Authors: MM Nowacka-Ch, D Li?kiewicz, A Li?kiewicz, M Przyby?a, ? Marczak, A Wojakowska, K Grabowska, M Grabowski, JJ Barski, A Ma?ecki
    Nutrients, 2022-05-05;14(9):.
    Species: Rat
    Sample Types: Serum
  29. Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth
    Authors: H Nishi, K Uchida, M Saito, D Yamanaka, H Nagata, H Tomoshige, I Miyata, K Ito, Y Toyoshima, SI Takahashi, F Hakuno, A Takenaka
    Cells, 2022-05-02;11(9):.
    Species: Mouse, Rat
    Sample Types: Serum
  30. Magnetically actuating implantable pump for the on-demand and needle-free administration of human growth hormone
    Authors: SH Lee, CR Kim, YC Cho, SN Kim, BH Kim, C Lee, HB Ji, JH Han, CG Park, H Hong, YB Choy
    International journal of pharmaceutics, 2022-03-12;618(0):121664.
    Species: Rat
    Sample Types: Plasma
  31. Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance
    Authors: E Mendes de, JC Silva, TP Ascar, S Sandri, AF Marchi, S Migliorini, HTI Nakaya, RA Fock, A Campa
    Pharmaceutics, 2022-03-11;14(3):.
    Species: Mouse
    Sample Types: Serum
  32. Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants
    Authors: J Dereke, E Ekblad, B Weström, C Erlanson-A, M Landin-Ols, I Sjöholm, M Hillman
    Scientific Reports, 2022-03-08;12(1):4039.
    Species: Rat
    Sample Types: Plasma
  33. Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases
    Authors: T Yamamotoya, S Hasei, Y Akasaka, Y Ohata, Y Nakatsu, M Kanna, M Fujishiro, H Sakoda, H Ono, A Kushiyama, H Misawa, T Asano
    Scientific Reports, 2022-02-04;12(1):1966.
    Species: Mouse
    Sample Types: Serum
  34. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
    Authors: F D'Addio, A Maestroni, E Assi, M Ben Nasr, G Amabile, V Usuelli, C Loretelli, F Bertuzzi, B Antonioli, F Cardarelli, B El Essawy, A Solini, IC Gerling, C Bianchi, G Becchi, S Mazzucchel, D Corradi, GP Fadini, D Foschi, JF Markmann, E Orsi, J Škrha, MG Camboni, R Abdi, AM James Shap, F Folli, J Ludvigsson, S Del Prato, G Zuccotti, P Fiorina
    Nature Communications, 2022-02-03;13(1):684.
    Species: Mouse
    Sample Types: Serum
  35. Combined Phyllostachys pubescens and Scutellaria baicalensis Prevent High-Fat Diet-Induced Obesity via Upregulating Thermogenesis and Energy Expenditure by UCP1 in Male C57BL/6J Mice
    Authors: YY Sung, SH Kim, DS Kim
    Nutrients, 2022-01-19;14(3):.
    Species: Mouse
    Sample Types: Serum
  36. Metabolic Rewiring by Human Placenta-Derived Mesenchymal Stem Cell Therapy Promotes Rejuvenation in Aged Female Rats
    Authors: KH Kim, KA Lee
    International Journal of Molecular Sciences, 2022-01-05;23(1):.
    Species: Rat
    Sample Types: Serum
  37. A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
    Authors: M Darnaud, F De Vadder, P Bogeat, L Boucinha, AL Bulteau, A Bunescu, C Couturier, A Delgado, H Dugua, C Elie, A Mathieu, T Novotná, DA Ouattara, S Planel, A Saliou, D Šr?tková, J Yansouni, B Stecher, M Schwarzer, F Leulier, A Tamellini
    Nature Communications, 2021-11-18;12(1):6686.
    Species: Mouse
    Sample Types: Serum
  38. Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition
    Authors: LCD Pomatto-Wa, M Bodogai, O Bosompra, J Kato, S Wong, M Carpenter, E Duregon, D Chowdhury, P Krishna, S Ng, E Ragonnaud, R Salgado, P Gonzalez E, A Diaz-Ruiz, M Bernier, NL Price, A Biragyn, VD Longo, R de Cabo
    Nature Communications, 2021-10-27;12(1):6201.
    Species: Mouse
    Sample Types: Serum
  39. Litter expansion alters metabolic homeostasis in a sex specific manner
    Authors: K Kurup, SN Mann, J Jackson, S Matyi, M Ranjo-Bish, WM Freeman, MB Stout, A Richardson, A Unnikrishn
    PLoS ONE, 2021-09-29;16(9):e0237199.
    Species: Mouse
    Sample Types: Tissue Homogenate
  40. Intramuscular injection of skeletal muscle derived extracellular matrix mitigates denervation atrophy after sciatic nerve transection
    Authors: BK Schilling, JS Baker, C Komatsu, KG Marra
    Journal of tissue engineering, 2021-09-19;12(0):2041731421103.
    Species: Rat
    Sample Types: Tissue Homogenates
  41. Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging
    Authors: P Maity, K Singh, L Krug, A Koroma, A Hainzl, W Bloch, S Kochanek, M Wlaschek, M Schorpp-Ki, P Angel, A Ignatius, H Geiger, K Scharffett
    Cell Reports, 2021-08-31;36(9):109634.
    Species: Transgenic Mouse
    Sample Types: Serum
  42. Muscle insulin-like growth factor-I modulates murine craniofacial bone growth
    Authors: HJ Kok, CN Crowder, L Koo Min Ch, HY Choi, N Lin, ER Barton
    European cells & materials, 2021-07-19;41(0):72-89.
    Species: Mouse
    Sample Types: Tissue Homogenates
  43. IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting alphaSMA
    Authors: S Ock, W Ham, CW Kang, H Kang, WS Lee, J Kim
    Cell Death & Disease, 2021-07-09;12(7):688.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  44. Telomerase activator-65 and pomegranate peel improved the health status of the liver in aged rats; multi-targets involved
    Authors: AS Alshinnawy, WM El-Sayed, AA Sayed, AM Salem, AM Taha
    Iranian journal of basic medical sciences, 2021-06-01;24(6):842-850.
    Species: Rat
    Sample Types: Serum
  45. Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes
    Authors: O Nychyk, W Barton, AM Rudolf, S Boscaini, A Walsh, TFS Bastiaanss, L Giblin, P Cormican, L Chen, Y Piotrowicz, D Derous, Á Fanning, X Yin, J Grant, S Melgar, L Brennan, SE Mitchell, JF Cryan, J Wang, PD Cotter, JR Speakman, KN Nilaweera
    Cell Reports, 2021-05-11;35(6):109093.
    Species: Mouse
    Sample Types: Plasma
  46. Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
    Authors: JD Plummer, SD Postnikoff, JK Tyler, JE Johnson
    Elife, 2021-03-30;10(0):.
    Species: Mouse
    Sample Types: Plasma
  47. Physiological and metabolic characteristics of novel double-mutant female mice with targeted disruption of both growth hormone-releasing hormone and growth hormone receptor
    Authors: M Icyuz, F Zhang, MP Fitch, MR Joyner, AK Challa, LY Sun
    Aging Cell, 2021-03-23;0(0):e13339.
    Species: Mouse
    Sample Types: Serum
  48. JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice
    Authors: DW Dodington, JL Yumol, J Yang, E Pollock-Ta, T Sivasubram, SM Sacco, SA Schroer, YE Li, H Le, WE Ward, M Woo
    JCI Insight, 2021-03-08;6(5):.
    Species: Mouse
    Sample Types: Serum
  49. Antioxidative Capacity of Liver- and Adipose-Derived Mesenchymal Stem Cell-Conditioned Media and Their Applicability in Treatment of Type 2 Diabetic Rats
    Authors: MM Elshemy, M Asem, KS Allemailem, K Uto, M Ebara, A Nabil
    Oxidative Medicine and Cellular Longevity, 2021-02-02;2021(0):8833467.
    Species: Rat
    Sample Types: Serum
  50. Shockwave Therapy Modulates the Expression of BMP2 for Prevention of Bone and Cartilage Loss in the Lower Limbs of Postmenopausal Osteoporosis Rat Model
    Authors: SL Hsu, WY Chou, CC Hsu, JY Ko, SW Jhan, CJ Wang, MS Lee, TC Hsu, JH Cheng
    Biomedicines, 2020-12-15;8(12):.
    Species: Rat
    Sample Types: Serum
  51. High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice
    Authors: SM Grundmann, A Schutkowsk, C Berger, AC Baur, B König, GI Stangl
    Sci Rep, 2020-11-27;10(1):20748.
    Species: Mouse
    Sample Types: Serum
  52. Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats
    Authors: M Portero-Tr, D Rojic-Beck, C Vega-Carba, G Guillazo-B, A Vale-Martí, M Martí-Nico
    Sci Rep, 2020-11-09;10(1):19299.
    Species: Rat
    Sample Types: Plasma
  53. Substrate Elasticity Exerts Functional Effects on Primary Microglia
    Authors: SJ Blaschke, S Demir, A König, JA Abraham, SU Vay, M Rabenstein, DN Olschewski, C Hoffmann, M Hoffmann, N Hersch, R Merkel, B Hoffmann, M Schroeter, GR Fink, MA Rueger
    Front Cell Neurosci, 2020-11-05;14(0):590500.
    Species: Rat
    Sample Types: Cell Culture Supernates
  54. IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants
    Authors: B Cakir, W Hellström, Y Tomita, Z Fu, R Liegl, A Winberg, I Hansen-Pup, D Ley, A Hellström, C Löfqvist, LE Smith
    JCI Insight, 2020-10-02;5(19):.
    Species: Mouse
    Sample Types: Plasma
  55. Optimized platelet rich plasma releasate (O-rPRP) repairs galactosemia-induced ovarian follicular loss in rats by activating mTOR signaling and inhibiting apoptosis
    Authors: W El Bakly, M Medhat, M Shafei, R Tash, M Elrefai, Y Shoukry, NN Omar
    Heliyon, 2020-09-21;6(9):e05006.
    Species: Rat
    Sample Types: Plasma
  56. GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
    Authors: D Abboud, AF Daly, N Dupuis, MA Bahri, A Inoue, A Chevigné, F Ectors, A Plenevaux, B Pirotte, A Beckers, J Hanson
    Nat Commun, 2020-09-21;11(1):4752.
    Species: Mouse
    Sample Types: Plasma
  57. Reduced brain fractalkine-CX3CR1 signaling is involved in the impaired cognition of streptozotocin-treated mice
    Authors: N Kawamura, G Katsuura, N Yamada-Got, E Novianti, A Inui, A Asakawa
    IBRO Rep, 2020-09-15;9(0):233-240.
    Species: Mouse
    Sample Types: Plasma
  58. Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1
    Authors: S Yamamoto, C Sakemoto, K Iwasa, K Maruyama, K Shimizu, K Yoshikawa
    J. Pharmacol. Sci., 2020-08-19;144(3):119-122.
    Species: Mouse
    Sample Types: Tissue Homogenates
  59. Combination Antioxidant/NSAID Therapies and Oral/Topical Ocular Delivery Modes for Prevention of Oxygen-Induced Retinopathy in a Rat Model
    Authors: KD Beharry, CL Cai, F Siddiqui, C D'Agrosa, A Zangaladze, G Mustafa, A Qadri, TJ Duggan, JV Aranda
    Nutrients, 2020-07-03;12(7):.
    Species: Rat
    Sample Types: Tissue Culture Supernates
  60. Apolipoprotein�J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity
    Authors: JA Seo, MC Kang, WM Yang, WM Hwang, SS Kim, SH Hong, JI Heo, A Vijyakumar, L Pereira de, A Uner, H Huang, SH Lee, IS Lima, KS Park, MS Kim, Y Dagon, TE Willnow, V Aroda, TP Ciaraldi, RR Henry, YB Kim
    Nat Commun, 2020-04-24;11(1):2024.
    Species: Mouse
    Sample Types: Serum
  61. Transplantation of Endothelial Progenitor Cells in Obese Diabetic Rats Following Myocardial Infarction: Role of Thymosin Beta-4
    Authors: KK Poh, PSS Lee, AH Djohan, MJ Galupo, GG Songco, TC Yeo, HC Tan, AM Richards, L Ye
    Cells, 2020-04-12;9(4):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  62. Bumetanide Suppression of Angiogenesis in a Rat Model of Oxygen-Induced Retinopathy
    Authors: S Guzel, CL Cai, T Ahmad, M Quan, GB Valencia, JV Aranda, KD Beharry
    Int J Mol Sci, 2020-02-02;21(3):.
    Species: Rat
    Sample Types: Serum
  63. Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats
    Authors: T Nemoto, Y Kakinuma
    Sci Rep, 2020-01-28;10(1):1339.
    Species: Rat
    Sample Types: Plasma
  64. Increased Susceptibility to Obesity and Glucose Intolerance in Adult Female Rats Programmed by High-Protein Diet during Gestation, But Not during Lactation
    Authors: C Desclée de, G Carlin, A Oosting, C Delteil, D Azzout-Mar, C Chaumontet, F Blachier, P Barbillon, T Mary-Huard, D Tomé, R Oozeer, AM Davila
    Nutrients, 2020-01-25;12(2):.
    Species: Mouse
    Sample Types: Plasma
  65. Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area
    Authors: S Sanchez-Be, ND Åberg, P Crock, FR Walker, M Nilsson, J Isgaard, LK Ong
    Int J Mol Sci, 2020-01-17;21(2):.
    Species: Mouse
    Sample Types: Plasma
  66. Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice
    Authors: R Nakao, T Abe, S Yamamoto, K Oishi
    Sci Rep, 2019-12-23;9(1):19652.
    Species: Mouse
    Sample Types: Plasma
  67. Food deprivation during active phase induces skeletal muscle atrophy via IGF-1 reduction in mice
    Authors: T Abe, R Kazama, H Okauchi, K Oishi
    Arch. Biochem. Biophys., 2019-10-19;0(0):108160.
    Species: Mouse
    Sample Types: Plasma
  68. Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model
    Authors: CC Hsiao, CC Lin, YS Hou, JY Ko, CJ Wang
    Int J Mol Sci, 2019-10-05;20(19):.
    Species: Rat
    Sample Types: Tissue Lysates
  69. Mesenchymal stem cell-derived conditioned medium attenuate angiotensin II-induced aortic aneurysm growth by modulating macrophage polarization
    Authors: YZ Zhou, Z Cheng, Y Wu, QY Wu, XB Liao, Y Zhao, JM Li, XM Zhou, XM Fu
    J. Cell. Mol. Med., 2019-10-04;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  70. Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure
    Authors: YF Mahran, AM Badr, A Aldosari, R Bin-Zaid, HN Alotaibi
    Oxid Med Cell Longev, 2019-08-20;2019(0):3173745.
    Species: Rat
    Sample Types: Serum
  71. Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific
    Authors: RG Paul, AS Hennebry, MS Elston, JV Conaglen, CD McMahon
    Skelet Muscle, 2019-06-24;9(1):19.
    Species: Mouse
    Sample Types: Plasma
  72. pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis
    Authors: D Kremer, J Gruchot, V Weyers, L Oldemeier, P Göttle, L Healy, J Ho Jang, Y Kang T Xu, C Volsko, R Dutta, BD Trapp, H Perron, HP Hartung, P Küry
    Proc. Natl. Acad. Sci. U.S.A., 2019-06-18;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  73. The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway
    Authors: P Shao, Y Wang, M Zhang, X Wen, J Zhang, Z Xu, M Hu, J Jiang, T Liu
    Ecotoxicol. Environ. Saf., 2019-06-15;181(0):362-369.
    Species: Rat
    Sample Types: Serum
  74. DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
    Authors: G Favaro, V Romanello, T Varanita, M Andrea Des, V Morbidoni, C Tezze, M Albiero, M Canato, G Gherardi, D De Stefani, C Mammucari, B Blaauw, S Boncompagn, F Protasi, C Reggiani, L Scorrano, L Salviati, M Sandri
    Nat Commun, 2019-06-12;10(1):2576.
    Species: Mouse
    Sample Types: Plasma
  75. Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy
    Authors: H Zhou, X Lei, Y Yan, T Lydic, J Li, NL Weintraub, H Su, W Chen
    JCI Insight, 2019-06-11;5(0):.
    Species: Mouse
    Sample Types: Plasma
  76. Implantable multireservoir device with stimulus-responsive membrane for on-demand and pulsatile delivery of growth hormone
    Authors: SH Lee, H Piao, YC Cho, SN Kim, G Choi, CR Kim, HB Ji, CG Park, C Lee, CI Shin, WG Koh, YB Choy, JH Choy
    Proc. Natl. Acad. Sci. U.S.A., 2019-05-23;0(0):.
    Species: Rat
    Sample Types: Plasma
  77. In-Depth Characterization of a Mifepristone-Regulated Expression System for AAV5-Mediated Gene Therapy in the Liver
    Authors: JM Liefhebber, R Martier, T Van der Zo, S Keskin, A Huseinovic, J Lubelski, B Blits, H Petry, P Konstantin
    Mol Ther Methods Clin Dev, 2019-05-16;13(0):512-525.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  78. A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
    Authors: G Sendžikait, CW Hanna, KR Stewart-Mo, E Ivanova, G Kelsey
    Nat Commun, 2019-04-23;10(1):1884.
    Species: Mouse
    Sample Types: Serum
  79. Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
    Authors: IV Kravchenko, VA Furalyov, VO Popov
    Biochem Biophys Rep, 2019-03-21;18(0):100627.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  80. Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF-1 pathway
    Authors: TT Williamson, B Ding, X Zhu, RD Frisina
    Aging Cell, 2019-03-07;0(0):e12939.
    Species: Mouse
    Sample Types: Serum
  81. Growth Hormone Improves Nerve Regeneration, Muscle Re-innervation, and Functional Outcomes After Chronic Denervation Injury
    Authors: J Lopez, A Quan, J Budihardjo, S Xiang, H Wang, Kiron Kosh, C Cashman, WPA Lee, A Hoke, S Tuffaha, G Brandacher
    Sci Rep, 2019-02-28;9(1):3117.
    Species: Rat
    Sample Types: Serum
  82. Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve
    Authors: Y Zhuo, L Hua, B Feng, X Jiang, J Li, D Jiang, X Huang, Y Zhu, Z Li, L Yan, C Jin, L Che, Z Fang, Y Lin, S Xu, J Li, Wu
    EBioMedicine, 2019-02-13;41(0):623-635.
    Species: Mouse
    Sample Types: Serum
  83. Pregnancy-Associated Plasma Protein-A Accelerates Atherosclerosis by Regulating Reverse Cholesterol Transport and Inflammation
    Authors: SL Tang, ZW Zhao, SM Liu, G Wang, XH Yu, J Zou, SQ Wang, XY Dai, MG Fu, XL Zheng, DW Zhang, H Fu, CK Tang
    Circ. J., 2019-01-18;0(0):.
    Species: Mouse
    Sample Types: Serum
  84. Topical essential fatty acid oil on wounds: Local and systemic effects
    Authors: BG Lania, J Morari, AR Almeida, MND Silva, G Vieira-Dam, KA Lins, CL César, LA Velloso, NB Maia, ML Cintra, PENF Velho
    PLoS ONE, 2019-01-04;14(1):e0210059.
    Species: Mouse
    Sample Types: Serum
  85. Potentiation of Glucagon-Like Peptide-2 Dynamics by Methotrexate Administration in Rat Small Intestine
    Authors: M Machida, S Shiga, T Machida, M Ohno, K Iizuka, M Hirafuji
    Biol. Pharm. Bull., 2019-01-01;42(10):1733-1740.
    Species: Rat
    Sample Types: Plasma
  86. Therapeutic effects of a mesenchymal stem cell?based insulin?like growth factor?1/enhanced green fluorescent protein dual gene sorting system in a myocardial infarction rat model
    Authors: S Jung, JH Kim, C Yim, M Lee, HJ Kang, D Choi
    Mol Med Rep, 2018-10-16;0(0):.
    Species: Rat
    Sample Types: Transfected Whole Cells
  87. Enhanced Pulsatile Growth Hormone Secretion and Altered Metabolic Hormones by in Vivo Hexarelin Treatment in Streptozotocin-Induced Diabetic Rats
    Authors: X Zhang, JK Yang, C Chen
    Int J Mol Sci, 2018-10-08;19(10):.
    Species: Rat
    Sample Types: Serum
  88. Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
    Authors: C Bárcena, PM Quirós, S Durand, P Mayoral, F Rodríguez, XM Caravia, G Mariño, C Garabaya, MT Fernández-, G Kroemer, JMP Freije, C López-Otín
    Cell Rep, 2018-08-28;24(9):2392-2403.
    Species: Mouse
    Sample Types: Plasma
  89. Myeloid p38? signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
    Authors: C Youssif, M Cubillos-R, M Comalada, E Llonch, C Perna, N Djouder, AR Nebreda
    EMBO Mol Med, 2018-07-01;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  90. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
    Authors: K Mao, GF Quipildor, T Tabrizian, A Novaj, F Guan, RO Walters, F Delahaye, GB Hubbard, Y Ikeno, K Ejima, P Li, DB Allison, H Salimi-Moo, PJ Beltran, P Cohen, N Barzilai, DM Huffman
    Nat Commun, 2018-06-19;9(1):2394.
    Species: Mouse
    Sample Types: Plasma
  91. The effect of the type of dietary protein on the development of ovarian cancer
    Authors: AAA Taha, M Koshiyama, N Matsumura, K Abiko, K Yamaguchi, J Hamanishi, T Baba, B Kharma, IH Mohamed, MM Ameen, SA Ismail, I Konishi, M Mandai
    Oncotarget, 2018-05-08;9(35):23987-23999.
    Species: Rat
    Sample Types: Serum
  92. Growth Hormone Improves Cognitive Function After Experimental Stroke
    Authors: LK Ong, WZ Chow, C TeBay, M Kluge, G Pietrogran, K Zalewska, P Crock, ND Åberg, A Bivard, SJ Johnson, FR Walker, M Nilsson, J Isgaard
    Stroke, 2018-04-10;0(0):.
    Species: Mouse
    Sample Types: Serum
  93. Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice
    Authors: J Lu, L Lu, Y Yu, J Cluette-Br, CR Martin, EC Claud
    Sci Rep, 2018-04-03;8(1):5443.
    Species: Mouse
    Sample Types: Serum
  94. The local cytokine and growth factor response to rhBMP-2 after spinal fusion
    Authors: JD Koerner, DZ Markova, GD Schroeder, BP Calio, A Shah, CW Brooks, AR Vaccaro, DG Anderson, CK Kepler
    Spine J, 2018-03-14;0(0):.
    Species: Rat
    Sample Types: Tissue Lysates
    Applications: ELISA (Standard)
  95. Intermittent hypoxia suppression of growth hormone and insulin-like growth factor-I in the neonatal rat liver
    Authors: C Cai, T Ahmad, GB Valencia, JV Aranda, J Xu, KD Beharry
    Growth Horm. IGF Res., 2018-03-08;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  96. Transplant of insulin-like growth factor-1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF-?B pathway
    Authors: L Wang, M Yang, M Jin, Y Wu, T Zheng, S Gu, X Hua
    J. Cell. Mol. Med., 2018-03-07;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  97. EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation
    Authors: M Linder, M Hecking, E Glitzner, K Zwerina, M Holcmann, L Bakiri, MG Ruocco, J Tuckermann, G Schett, EF Wagner, M Sibilia
    Cell Death Differ., 2018-02-14;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  98. The Protective Effects of IGF-I against ?-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A
    Authors: D Aguado-Lle, S Canelles, LM Frago, JA Chowen, J Argente, E Arilla, V Barrios
    Neuroscience, 2018-02-03;374(0):104-118.
    Species: Rat
    Sample Types: Tissue Homogenates
  99. Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis
    Authors: Y Takahashi, R Watanabe, Y Sato, N Ozawa, M Kojima, K Watanabe-K, R Shirai, K Sato, T Hirano, T Watanabe
    Metab. Clin. Exp., 2018-02-02;0(0):.
    Species: Mouse
    Sample Types: Plasma
  100. Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus)
    Authors: BG Lania, J Morari, AL Souza, MND Silva, AR de Almeida, G Veira-Dami, SM Alegre, CL César, LA Velloso, ML Cintra, NB Maia, PENF Velho
    PLoS ONE, 2017-12-13;12(12):e0188779.
    Species: Rat
    Sample Types: Serum
  101. Supplementation of suckling rats with cow's milk induces hyperphagia and higher visceral adiposity in females at adulthood, but not in males
    Authors: VST Rodrigues, EG Moura, DN Bernardino, JC Carvalho, PN Soares, TC Peixoto, N Peixoto-Si, E Oliveira, PC Lisboa
    J. Nutr. Biochem., 2017-12-10;55(0):89-103.
    Species: Rat
    Sample Types: Serum
  102. Changes of Cerebral and/or Peripheral Adenosine A? Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats
    Authors: M Chennaoui, PJ Arnal, R Dorey, F Sauvet, S Ciret, T Gallopin, D Leger, C Drogou, D Gomez-Meri
    Int J Mol Sci, 2017-11-17;18(11):.
    Species: Rat
    Sample Types: Plasma
  103. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins
    Authors: KN Charles, MD Li, F Engin, AP Arruda, K Inouye, GS Hotamislig
    Cell Rep, 2017-10-10;21(2):393-402.
    Species: Mouse
    Sample Types: Serum
  104. Effects of growth hormone on cardiac remodeling and soleus muscle in rats with aortic stenosis-induced heart failure
    Authors: ARR Lima, LU Pagan, RL Damatto, MDM Cezar, C Bonomo, MJ Gomes, PF Martinez, DM Guizoni, DHS Campos, FC Damatto, K Okoshi, MP Okoshi
    Oncotarget, 2017-08-24;8(47):83009-83021.
    Species: Rat
    Sample Types: Serum
  105. Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction
    Authors: R Cintron-Co, M Sanchez-Al, W Nguyen, S Mori, R Gonzalez-R, T Lien, T Bartfai, S Aïd, JC François, M Holzenberg, B Conti
    Proc. Natl. Acad. Sci. U.S.A., 2017-08-21;0(0):.
    Species: Mouse
    Sample Types: Serum
  106. Corticotrophin-releasing hormone and corticosterone impair development of preimplantation embryos by inducing oviductal cell apoptosis via activating the Fas system: an in vitro study
    Authors: XW Tan, CL Ji, LL Zheng, J Zhang, HJ Yuan, S Gong, J Zhu, JH Tan
    Hum. Reprod., 2017-08-01;0(0):1-15.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  107. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease
    Authors: M Kugita, K Nishii, T Yamaguchi, A Suzuki, Y Yuzawa, S Horie, E Higashihar, S Nagao
    PLoS ONE, 2017-05-18;12(5):e0177934.
    Species: Rat
    Sample Types: Serum
  108. A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects
    Authors: M Kondo, Y Koyama, Y Nakamura, S Shimada
    Mol. Psychiatry, 2017-04-25;0(0):.
    Species: Mouse
    Sample Types: Serum
  109. IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan
    Authors: NM Ashpole, S Logan, A Yabluchans, MC Mitschelen, H Yan, JA Farley, EL Hodges, Z Ungvari, A Csiszar, S Chen, C Georgescu, GB Hubbard, Y Ikeno, WE Sonntag
    Geroscience, 2017-04-13;0(0):.
    Species: Mouse
    Sample Types: Serum
  110. Metformin inhibits the proliferation of benign prostatic epithelial cells
    Authors: Z Wang, X Xiao, R Ge, J Li, CW Johnson, C Rassoulian, AF Olumi
    PLoS ONE, 2017-03-02;12(3):e0173335.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  111. Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth
    Authors: S Becker, H Wang, B Yu, R Brown, X Han, RH Lane, ME Hartnett
    Sci Rep, 2017-02-14;7(0):42301.
    Species: Rat
    Sample Types: Serum
  112. Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice
    Authors: L Luo, C Yan, Y Urata, AS Hasan, S Goto, CY Guo, S Zhang, TS Li
    Sci Rep, 2017-01-18;7(0):40959.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  113. Mosaic expression of Atrx in the mouse central nervous system causes memory deficits
    Authors: RJ Tamming, JR Siu, Y Jiang, MA Prado, F Beier, NG B?rub?
    Dis Model Mech, 2017-01-12;10(2):119-126.
    Species: Mouse
    Sample Types: Plasma
  114. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome
    Authors: Lisa C Burnett
    J. Clin. Invest, 2016-12-12;0(0):.
    Species: Mouse
    Sample Types: Plasma
  115. Positive Prehabilitative Effect of Intense Treadmill Exercise for Ameliorating Cancer Cachexia Symptoms in a Mouse Model
    J Cancer, 2016-12-09;7(15):2378-2387.
    Species: Mouse
    Sample Types: Plasma
  116. The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats
    J Neuroinflammation, 2016-12-01;13(1):300.
    Species: Rat
    Sample Types: Serum
  117. Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery
    Authors: Li Zhou
    Biomaterials, 2016-11-27;117(0):24-31.
    Species: Mouse
    Sample Types: Plasma
  118. First steps to define murine amniotic fluid stem cell microenvironment
    Sci Rep, 2016-11-15;6(0):37080.
    Species: Mouse
    Sample Types: Amniotic Fluid
  119. The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells
    Authors: MC Fernandez, R Rayes, B Ham, N Wang, F Bourdeau, S Milette, M Lllemann, N Bird, A Majeed, J Xu, T Kisselova, P Brodt
    Oncotarget, 2016-10-12;8(32):52281-52293.
    Species: Mouse
    Sample Types: Serum
  120. Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine
    Sci Rep, 2016-08-25;6(0):31853.
    Species: Mouse
    Sample Types: Serum
  121. Single ingestion of soy ?-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
    Authors: Tsutomu Hashidume
    Sci Rep, 2016-06-17;6(0):28183.
    Species: Mouse
    Sample Types: Serum
  122. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction
    Authors: Thor Tejada
    Proc Natl Acad Sci USA, 2016-06-06;0(0):.
    Species: Mouse
    Sample Types: Serum
  123. Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart
    PLoS ONE, 2016-05-19;11(5):e0155611.
    Species: Mouse
    Sample Types: Plasma
  124. Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice
    PLoS ONE, 2016-05-19;11(5):e0152179.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  125. Fibroblast growth factor 21 has no direct role in regulating fertility in female mice
    Mol Metab, 2016-05-18;5(8):690-8.
    Species: Mouse
    Sample Types: Plasma
  126. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
    Authors: Baker D, Childs B, Durik M, Wijers M, Sieben C, Zhong J, Saltness R, Jeganathan K, Verzosa G, Pezeshki A, Khazaie K, Miller J, van Deursen J
    Nature, 2016-02-03;530(7589):184-9.
    Species: Mouse
    Sample Types: Serum
  127. MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms.
    Authors: Conti V, Gandaglia A, Galli F, Tirone M, Bellini E, Campana L, Kilstrup-Nielsen C, Rovere-Querini P, Brunelli S, Landsberger N
    PLoS ONE, 2015-06-22;10(6):e0130183.
    Species: Mouse
    Sample Types: Plasma
  128. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
    Authors: Charolidi N, Schilling T, Eder C
    PLoS ONE, 2015-05-26;10(5):e0128463.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  129. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
    Authors: Sapra, Geeta, Tham, Yow Keat, Cemerlang, Nelly, Matsumoto, Aya, Kiriazis, Helen, Bernardo, Bianca C, Henstridge, Darren C, Ooi, Jenny Y, Pretorius, Lynette, Boey, Esther J, Lim, Lydia, Sadoshima, Junichi, Meikle, Peter J, Mellet, Natalie, Woodcock, Elizabet, Marasco, Silvana, Ueyama, Tomomi, Du, Xiao-Jun, Febbraio, Mark A, McMullen, Julie R
    Nat Commun, 2014-12-09;5(0):5705.
    Species: Mouse
    Sample Types: Plasma
  130. Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability.
    Authors: Nguyen K, Yao X, Erickson A, Mishra S, Nyomba B
    Endocrinology, 2014-12-09;156(2):462-74.
    Species: Mouse
    Sample Types: Serum
  131. The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.
    Authors: Nuytens, Kim, Tuand, Krizia, Fu, Quili, Stijnen, Pieter, Pruniau, Vincent, Meulemans, Sandra, Vankelecom, Hugo, Creemers, John W M
    PLoS ONE, 2014-10-15;9(10):e109598.
    Species: Mouse
    Sample Types: Plasma
  132. Survival of neural stem cell grafts in the lesioned spinal cord is enhanced by a combination of treadmill locomotor training via insulin-like growth factor-1 signaling.
    Authors: Hwang D, Shin H, Kwon M, Choi J, Ryu B, Kim B
    J Neurosci, 2014-09-17;34(38):12788-800.
    Species: Rat
    Sample Types: Serum
  133. Long-term physiological alterations and recovery in a mouse model of separation associated with time-restricted feeding: a tool to study anorexia nervosa related consequences.
    Authors: Zgheib S, Mequinion M, Lucas S, Leterme D, Ghali O, Tolle V, Zizzari P, Bellefontaine N, Legroux-Gerot I, Hardouin P, Broux O, Viltart O, Chauveau C
    PLoS ONE, 2014-08-04;9(8):e103775.
    Species: Mouse
    Sample Types: Plasma
  134. sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.
    Authors: Baltes J, Larsen J, Radhakrishnan K, Geumann C, Kratzke M, Petersen C, Schu P
    J Cell Sci, 2014-06-13;127(0):3477-87.
    Species: Mouse
    Sample Types: Serum
  135. The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice.
    Authors: Kuno T, Hata K, Takamatsu M, Hara A, Hirose Y, Takahashi S, Imaida K, Tanaka T
    Int J Mol Sci, 2014-05-22;15(5):9160-72.
    Species: Mouse
    Sample Types: Plasma
  136. Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.
    Authors: Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M
    PLoS ONE, 2014-05-09;9(5):e96305.
    Species: Rat
    Sample Types: Serum
  137. Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.
    Authors: Harvey A, Lashinger L, Hays D, Harrison L, Lewis K, Fischer S, Hursting S
    PLoS ONE, 2014-05-07;9(5):e94151.
    Species: Mouse
    Sample Types: Serum
  138. Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
    Authors: Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S
    J Biol Chem, 2014-04-28;289(26):18327-38.
    Species: Mouse
    Sample Types: Tissue Homogenates
  139. IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice.
    Authors: Mellott T, Pender S, Burke R, Langley E, Blusztajn J
    PLoS ONE, 2014-04-14;9(4):e94287.
    Species: Mouse
    Sample Types: Tissue Homogenates
  140. HGF signaling impacts severity of Pseudomonas aeruginosa keratitis.
    Authors: Jiang X, McClellan S, Barrett R, Foldenauer M, Hazlett L
    Invest Ophthalmol Vis Sci, 2014-04-09;55(4):2180-90.
    Species: Mouse
    Sample Types: Tissue Homogenates
  141. The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle.
    Authors: Ogasawara R, Sato K, Matsutani K, Nakazato K, Fujita S
    Am J Physiol Endocrinol Metab, 2014-04-01;306(10):E1155-62.
    Species: Rat
    Sample Types: Serum
  142. Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception.
    Authors: Oduwole O, Vydra N, Wood N, Samanta L, Owen L, Keevil B, Donaldson M, Naresh K, Huhtaniemi I
    FASEB J, 2014-03-05;28(6):2566-76.
    Species: Mouse
    Sample Types: Serum
  143. Sonic hedgehog gene therapy increases the ability of the dystrophic skeletal muscle to regenerate after injury.
    Authors: Piccioni A, Gaetani E, Palladino M, Gatto I, Smith R, Neri V, Marcantoni M, Giarretta I, Silver M, Straino S, Capogrossi M, Landolfi R, Pola R
    Gene Ther, 2014-02-27;21(4):413-21.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  144. Viral expression of insulin-like growth factor I E-peptides increases skeletal muscle mass but at the expense of strength.
    Authors: Brisson, Becky K, Spinazzola, Janelle, Park, SooHyun, Barton, Elisabet
    Am J Physiol Endocrinol Metab, 2014-02-25;306(8):E965-74.
    Species: Mouse
    Sample Types: Tissue Homogenates
  145. Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey.
    Authors: Izumi, Hirohisa, Kosaka, Nobuyosh, Shimizu, Takashi, Sekine, Kazunori, Ochiya, Takahiro, Takase, Mitsunor
    PLoS ONE, 2014-02-12;9(2):e88843.
    Species: Rat
    Sample Types: Serum
  146. Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females.
    Authors: Parlee, Sebastia, Simon, Becky R, Scheller, Erica L, Alejandro, Emilyn U, Learman, Brian S, Krishnan, Venkates, Bernal-Mizrachi, Ernesto, MacDougald, Ormond A
    Endocrinology, 2014-01-23;155(4):1313-26.
    Species: Mouse
    Sample Types: Serum
  147. Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast.
    Authors: Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S
    J Exp Med, 2013-12-23;211(1):153-63.
    Species: Mouse
    Sample Types: Serum
  148. Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.
    Authors: Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst E, Keijer J, Klaus S
    Am J Physiol Endocrinol Metab, 2013-12-17;306(5):E469-82.
    Species: Mouse
    Sample Types: Plasma
  149. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease.
    Authors: Burke R, Norman T, Haydar T, Slack B, Leeman S, Blusztajn J, Mellott T
    Proc Natl Acad Sci U S A, 2013-11-11;110(48):19567-72.
    Species: Mouse
    Sample Types: Tissue Homogenates
  150. Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice.
    Authors: Steyn, F J, Lee, K, Fogarty, M J, Veldhuis, J D, McCombe, P A, Bellingham, M C, Ngo, S T, Chen, C
    Endocrinology, 2013-10-09;154(12):4695-706.
    Species: Mouse
    Sample Types: Plasma
  151. IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter.
    Authors: Ock, Sangmi, Ahn, Jihyun, Lee, Seok Hon, Kang, Hyun, Offermanns, Stefan, Ahn, Hwa Youn, Jo, Young Su, Shong, Minho, Cho, Bo Youn, Jo, Daewoong, Abel, E Dale, Lee, Tae Jin, Park, Woo Jin, Lee, In-Kyu, Kim, Jaetaek
    FASEB J, 2013-08-27;27(12):4899-908.
    Species: Mouse
    Sample Types: Serum
  152. SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.
    Authors: Yamamoto, Masaaki, Iguchi, Genzo, Fukuoka, Hidenori, Suda, Kentaro, Bando, Hironori, Takahashi, Michiko, Nishizawa, Hitoshi, Seino, Susumu, Takahashi, Yutaka
    Proc Natl Acad Sci U S A, 2013-08-26;110(37):14948-53.
    Species: Mouse
    Sample Types: Serum
  153. Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression.
    Authors: Lloyd J, Masko E, Wu C, Keenan M, Pilla D, Aronson W, Chi J, Freedland S
    Prostate Cancer Prostatic Dis, 2013-07-23;16(4):285-91.
    Species: Mouse
    Sample Types: Serum
  154. Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.
    Authors: Al-Qusairi L, Prokic I, Amoasii L, Kretz C, Messaddeq N, Mandel J, Laporte J
    FASEB J, 2013-05-21;27(8):3384-94.
    Species: Mouse
    Sample Types: Plasma
  155. Effects of breastfeeding on body composition and maturational tempo in the rat.
    Authors: Crispel, Yonatan, Katz, Oren, Ben-Yosef, Dafna, Hochberg, Ze'ev
    BMC Med, 2013-04-29;11(0):114.
    Species: Rat
    Sample Types: Serum
  156. IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
    Authors: Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H
    Stem Cells, 2013-04-01;31(4):627-40.
    Species: Mouse
    Sample Types: Cell Lysates
  157. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function.
    Authors: Sen S, Jumaa H, Webster N
    Nat Commun, 2013-01-01;4(0):1336.
    Species: Mouse
    Sample Types: Serum
  158. The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function.
    Authors: Takehara, Yuji, Yabuuchi, Akiko, Ezoe, Kenji, Kuroda, Tomoko, Yamadera, Rie, Sano, Chiaki, Murata, Nana, Aida, Takuya, Nakama, Ken, Aono, Fumihito, Aoyama, Naoki, Kato, Keiich, Kato, Osamu
    Lab Invest, 2012-11-19;93(2):181-93.
    Species: Rat
    Sample Types: Cell Culture Supernates
  159. Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice.
    Authors: Al-Dwairi, Ahmed, Pabona, John Mar, Simmen, Rosalia, Simmen, Frank A
    PLoS ONE, 2012-10-04;7(10):e46716.
    Species: Mouse
    Sample Types: Serum
  160. Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway.
    Authors: Ma B, Zhang Q, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ
    Acta Pharmacol. Sin., 2012-03-19;33(4):479-89.
    Species: Rat
    Sample Types: Serum
  161. Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.
    Authors: Hua Y, Sahashi K, Rigo F
    Nature, 2011-10-05;478(7367):123-6.
    Species: Mouse
    Sample Types: Serum
  162. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
    Authors: Maurer GD, Brucker DP, Bahr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J
    BMC Cancer, 2011-07-26;11(0):315.
    Species: Mouse
    Sample Types: Serum
  163. Caloric restriction reduces growth of mammary tumors and metastases.
    Authors: De Lorenzo M, Baljinnyam E, Vatner D, Abarzua P, Vatner S, Rabson A
    Carcinogenesis, 2011-06-10;32(9):1381-7.
    Species: Mouse
    Sample Types: Serum
  164. Human IGF Binding Protein-3 Overexpression Impairs Glucose Regulation in Mice via an Inhibition of Insulin Secretion.
    Authors: Nguyen KH, Yao XH, Moulik S, Mishra S, Nyomba BL
    Endocrinology, 2011-03-29;152(6):2184-96.
    Species: Mouse
    Sample Types: Plasma
  165. Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
    Authors: Sato H, Isogai Y, Masuda S
    J. Biol. Chem., 2011-01-25;286(13):11632-48.
    Species: Mouse
    Sample Types: Serum
  166. Rim2alpha determines docking and priming States in insulin granule exocytosis.
    Authors: Yasuda T, Shibasaki T, Minami K
    Cell Metab., 2010-08-04;12(2):117-29.
    Species: Mouse
    Sample Types: Serum
  167. Myocytic androgen receptor controls the strength but not the mass of limb muscles.
    Authors: Chambon C, Duteil D, Vignaud A, Ferry A, Messaddeq N, Malivindi R, Kato S, Chambon P, Metzger D
    Proc. Natl. Acad. Sci. U.S.A., 2010-07-26;107(32):14327-32.
    Species: Mouse
    Sample Types: Plasma
  168. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
    Authors: Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K
    Neurobiol. Dis., 2010-01-04;38(1):36-46.
    Species: Mouse
    Sample Types: Tissue Homogenates
  169. Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.
    Authors: Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M
    J. Neurochem., 2009-09-24;111(6):1409-24.
    Species: Mouse
    Sample Types: Tissue Homogenates
  170. Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system.
    Authors: Yang H, Dixit VD, Patel K, Vandanmagsar B, Collins G, Sun Y, Smith RG, Taub DD
    Brain Behav. Immun., 2008-06-17;0(0):.
    Species: Mouse
    Sample Types: Serum
  171. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
    Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
    Am. J. Respir. Crit. Care Med., 2008-04-24;178(2):149-57.
    Species: Mouse
    Sample Types: Serum
  172. Modulation of melanocortin signaling ameliorates uremic cachexia.
    Authors: Cheung WW, Rosengren S, Boyle DL, Mak RH
    Kidney Int., 2008-04-23;74(2):180-6.
    Species: Mouse
    Sample Types: Tissue Homogenates
  173. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
    Authors: Paintlia AS, Paintlia MK, Singh AK, Singh I
    Mol. Pharmacol., 2008-01-31;73(5):1381-93.
    Species: Rat
    Sample Types: Serum
  174. Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat.
    Authors: Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y
    Biochem. Biophys. Res. Commun., 2008-01-15;368(1):81-7.
    Species: Mouse
    Sample Types: Plasma
  175. Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.
    Authors: Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB
    Biochem. Pharmacol., 2007-11-12;75(5):1093-103.
    Species: Rat
    Sample Types: Plasma
  176. Ghrelin promotes thymopoiesis during aging.
    Authors: Dixit VD, Yang H, Sun Y, Weeraratna AT, Youm YH, Smith RG, Taub DD
    J. Clin. Invest., 2007-10-01;117(10):2778-90.
    Species: Mouse
    Sample Types: Serum
  177. Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.
    Authors: Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW
    Exp. Cell Res., 2007-09-20;313(20):4120-9.
    Species: Mouse
    Sample Types: Serum
  178. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2.Lewis rat.
    Authors: Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC
    Am. J. Physiol. Heart Circ. Physiol., 2007-07-13;293(4):H2064-71.
    Species: Rat
    Sample Types: Plasma
  179. Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord.
    Authors: Engesser-Cesar C, Anderson AJ, Cotman CW
    Neuroscience, 2006-11-28;144(3):1033-44.
    Species: Mouse
    Sample Types: Serum

FAQs

  1. Does this assay recognize total or free IGF-I?

    • This assay measures total IGF-I. IGF-I bound to IGF Binding Proteins and free IGF-I are detected.

View all ELISA FAQs
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Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 06/28/2022
Sample Tested: Cell culture supernatant
Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit MG100
Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 12/11/2021
Sample Tested: HUVEC human umbilical vein endothelial cells
Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit MG100
Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 07/06/2021
Sample Tested: Serum
Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit MG100
Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 12/09/2020
Sample Tested: rat spinal cord,Spinal cord tissue

Used on rat spinal cord samples and had excellent results.

Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit
By Jonatan Dereke on 11/17/2020
Sample Tested: EDTA Plasma

The performance of this analysis was great with samples in the log part of the standard curve.

Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit MG100
Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 04/10/2019
Sample Tested: EDTA Plasma

We routinely use this ELISA to quantify mouse IGF-1 levels. We have published data from this ELISA. The data shown here confirms previously published data suggesting that IGFBP-1-KO causes increase in IGF-1 levels

Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit MG100
Mouse/Rat IGF-I Quantikine ELISA Kit
By Leslie Priddy on 04/01/2018
Sample Tested: Serum
Mouse/Rat IGF-I Quantikine ELISA Kit
By Adam Guess on 11/08/2016
Sample Tested: Cell Culture Supernates
Mouse/Rat IGF-I Quantikine ELISA Kit MG100