Home / NMDA Receptor Modulators / (R)-Norketamine hydrochloride

(R)-Norketamine hydrochloride

Catalog #: 5996
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5996/10
(R)-Norketamine hydrochloride | CAS No. 83777-68-8 | NMDA Receptor Modulators
1 Image
Description: NMDA receptor modulator; analgesic

Chemical Name: (R)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(R)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 91 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.

S-enantiomer and racemate also available.

Technical Data

M.Wt:
260.16
Formula:
C12H14ClNO.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
83777-68-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
S-enantiomer and racemate also available.

Background References

  1. KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells.
    Singh et al.
    PLoS One, 2016;11:e0149499
  2. Effects of norKA enantiomers in rodent models of persistent pain.
    Holtman et al.
    Pharmacol.Biochem.Behav., 2008;909:676

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for (R)-Norketamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (R)-Norketamine hydrochloride include:

1 Citation: Showing 1 - 1

  1. (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism.
    Authors: Ago Et al.
    Int J Neuropsychopharmacol  2019;22:665

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for (R)-Norketamine hydrochloride

There are currently no reviews for this product. Be the first to review (R)-Norketamine hydrochloride and earn rewards!

Have you used (R)-Norketamine hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.