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(S)-Norketamine hydrochloride

Catalog #: 6112
1 Citation Datasheet / COA / SDS
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6112/10
(S)-Norketamine hydrochloride | CAS No. 83777-70-2 | NMDA Receptor Modulators
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Description: NMDA receptor modulator; analgesic

Chemical Name: (S)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(S)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.

R-enantiomer and racemate also available.

Technical Data

M.Wt:
260.16
Formula:
C12H14ClNO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
83777-70-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
R-enantiomer and racemate also available.

Background References

  1. KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells.
    Singh et al.
    PLoS One, 2016;11:e0149499
  2. Effects of norKA enantiomers in rodent models of persistent pain.
    Holtman et al.
    Pharmacol.Biochem.Behav., 2008;909:676

Product Datasheets

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Citation for (S)-Norketamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (S)-Norketamine hydrochloride include:

1 Citation: Showing 1 - 1

  1. (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine metabolites via an AMPA receptor-independent mechanism.
    Authors: Ago Et al.
    Int J Neuropsychopharmacol  2019;22:665

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