Recombinant Human IGF-I R/IGF1R Protein, CF Summary
Product Specifications
Met1-Asn932
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
391-GR
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: IGF-I R/IGF1R
IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and II have been shown to be mediated via IGF-I R.
- Rechler, M.M. and S.P. Nissley (1990) in Insulin-Like Growth Factors. Sporn, M.B. and A.B. Roberts (eds): Peptide Growth Factors and Their Receptors I, New York: Springer-Verlag, p. 263.
Citations for Recombinant Human IGF-I R/IGF1R Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
9
Citations: Showing 1 - 9
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Sequence tolerance of immunoglobulin variable domain framework regions to non-canonical intradomain disulfide linkages
Authors: Kim, DY;Kandalaft, H;Lowden, MJ;Yang, Q;Rossotti, MA;Robotham, A;Kelly, JF;Hussack, G;Schrag, JD;Henry, KA;Tanha, J;
The Journal of biological chemistry
Species: Human
Sample Types: Protein
Applications: Surface Plasmon Resonance -
Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor
Authors: A Yogi, G Hussack, H van Faasse, AS Haqqani, CE Delaney, E Brunette, JK Sandhu, M Hewitt, T Sulea, K Kemmerich, DB Stanimirov
Pharmaceutics, 2022-07-12;14(7):.
Species: Human
Sample Types: Recombinant Protein
Applications: SPR -
Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor
Authors: J Sheff, P Wang, P Xu, M Arbour, L Masson, H van Faasse, G Hussack, K Kemmerich, E Brunette, D Stanimirov, JJ Hill, J Kelly, F Ni
Scientific Reports, 2021-02-19;11(1):4284.
Species: Human
Sample Types: Whole Cells
Applications: Surface Plasmon Resonance -
A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer
Authors: NO Yunn, M Park, S Park, J Lee, J Noh, E Shin, SH Ryu
Nucleic Acids Research, 2021-01-25;49(2):700-712.
Species: Human
Sample Types: DNA
Applications: Bioassay -
Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer
Authors: VR Solomon, E Alizadeh, W Bernhard, A Makhlouf, SV Hartimath, W Hill, A El-Sayed, K Barreto, CR Geyer, H Fonge
Sci Rep, 2020-10-29;10(1):18549.
Species: Human
Sample Types: Peptide
Applications: Bioassay -
Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors
Authors: B Akla, M Broussas, N Loukili, A Robert, C Beau-Larvo, M Malissard, N Boute, T Champion, JF Haeuw, A Beck, M Perez, C Dreyfus, M Pavlyuk, E Chetaille, N Corvaia
Mol. Cancer Ther., 2019-10-08;0(0):.
Species: Human, Mouse
Sample Types: In Vivo, Recombinant Protein
Applications: ELISA, In Vivo -
Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling
Authors: DM Cedano Pri, Y Cheng, CC Chang, J Yu, YK Takada, Y Takada
PLoS ONE, 2017-09-05;12(9):e0184285.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA -
A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies
PLoS ONE, 2016-09-15;11(9):e0163113.
Applications: Surface Plasmon Resonance -
Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes.
Authors: Back K, Arnqvist HJ
Growth Horm. IGF Res., 2008-08-09;19(2):101-11.
Applications: ELISA (Standard)
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