Recombinant Human IL-6 Protein

Progressively enhancing stemness of adoptively transferred T cells with PI3K? blockade improves metabolism and anti-tumor immunity
Authors: Rangel Rivera, GO;Dwyer, CJ;Knochelmann, HM;Smith, AS;Aksoy, BA;Cole, AC;Wyatt, MM;Kumaresan, S;Thaxton, JE;Lesinski, GB;Paulos, CM;
Cancer research
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

Factors Influencing Marker Expressions of Cultured Human Cord Blood-Derived Mast Cells
Authors: Alimohammadi, S;Masuda-Kuroki, K;Szöll?si, AG;Di Nardo, A;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-6 trans-signaling in a humanized mouse model of scleroderma
Authors: Odell, ID;Agrawal, K;Sefik, E;Odell, AV;Caves, E;Kirkiles-Smith, NC;Horsley, V;Hinchcliff, M;Pober, JS;Kluger, Y;Flavell, RA;
Proceedings of the National Academy of Sciences of the United States of America
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TNF? induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
Authors: Twarog, M;Schustak, J;Xu, Y;Coble, M;Dolan, K;Esterberg, R;Huang, Q;Saint-Geniez, M;Bao, Y;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease
Authors: Vaikunthanathan, T;Landmann, E;Correa, DM;Romano, M;Trevelin, SC;Peng, Q;Crespo, E;Corrado, M;Lozano, JJ;Pearce, EL;Perpinan, E;Zoccarato, A;Siew, L;Edwards-Hicks, J;Khan, R;Luu, NT;Thursz, MR;Newsome, PN;Martinez-Llordella, M;Shah, N;Lechler, RI;Shah, AM;Sanchez-Fueyo, A;Lombardi, G;Safinia, N;
EBioMedicine
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Plug-and-play protein biosensors using aptamer-regulated in vitro transcription
Authors: Lee, H;Xie, T;Yu, X;Schaffter, SW;Schulman, R;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay

IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation
Authors: Converti, A;Bianchi, MS;Martinez, MD;Montaner, AD;Lux-Lantos, V;Bonaventura, MM;
Physiological reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts
Authors: A Di Nardo, YL Chang, S Alimohamma, K Masuda-Kur, Z Wang, K Sriram, PA Insel
Cell Reports, 2023-04-28;42(5):112453.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Extending the dynamic range of biomarker quantification through molecular equalization
Authors: Newman, S;Wilson, B;Mamerow, D;Wollant, B;Nyein, H;Rosenberg-Hasson, Y;Maecker, H;Eisenstein, M;Soh, H;
bioRxiv
Species: Human
Sample Types: Serum
Applications: Bioassay

IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma
Authors: Y Fukawa, K Kayamori, M Tsuchiya, T Ikeda
International Journal of Molecular Sciences, 2022-12-30;24(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses
Authors: L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy
Viruses, 2022-12-29;15(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gene Expression Linked to Reepithelialization of Human Skin Wounds
Authors: MS Ågren, T Litman, JO Eriksen, P Schjerling, M Bzorek, LMR Gjerdrum
International Journal of Molecular Sciences, 2022-12-12;23(24):.
Species: Human
Sample Types: Whole Cells
Applications: cell cutlure

IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia
Authors: X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama
Embo Molecular Medicine, 2022-12-01;0(0):e15631.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A portable analog front-end system for label-free sensing of proteins using nanowell array impedance sensors
Authors: M Tayyab, P Xie, MA Sami, H Raji, Z Lin, Z Meng, SR Mahmoodi, M Javanmard
Scientific Reports, 2022-11-22;12(1):20119.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Standard

Improved Sendai viral system for reprogramming to naive pluripotency.
Authors: Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S
Cell Rep Methods, 2022-10-17;2(11):100317.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
Science Advances, 2022-08-24;8(34):eabn5522.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
Authors: AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler
Cells, 2022-08-19;11(16):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation

Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein
Authors: MY Wang, CM Zhang, HH Zhou, ZB Ge, CC Su, ZH Lou, XY Zhang, TT Xu, SY Li, L Zhu, YL Zhou, Y Wu, SR Ji
Oncogene, 2022-06-17;0(0):102160.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway
Authors: A Dritsoula, L Dowsett, C Pilotti, MN O'Connor, SE Moss, J Greenwood
Scientific Reports, 2022-03-22;12(1):4867.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells
Authors: P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes
Cancers, 2022-03-11;14(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival
Authors: J Whitburn, SR Rao, EV Morris, S Tabata, A Hirayama, T Soga, JR Edwards, Z Kaya, C Palmer, FC Hamdy, CM Edwards
Science Advances, 2022-02-25;8(8):eabf9096.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer
Authors: T Matsumoto, H Okayama, S Nakajima, K Saito, M Ito, A Kaneta, Y Kanke, H Onozawa, S Hayase, S Fujita, W Sakamoto, M Saito, Z Seze, T Momma, K Mimura, K Kono
British Journal of Cancer, 2021-12-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo
Authors: SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis
PLoS ONE, 2021-11-09;16(11):e0248034.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling In Vitro Osteoarthritis Phenotypes in a Vascularized Bone Model Based on a Bone-Marrow Derived Mesenchymal Cell Line and Endothelial Cells
Authors: A Pirosa, EB Tankus, A Mainardi, P Occhetta, L Dönges, C Baum, M Rasponi, I Martin, A Barbero
International Journal of Molecular Sciences, 2021-09-03;22(17):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells
Authors: G Carbotti, B Dozin, S Martini, C Giordano, F Scordamagl, M Croce, G Filaci, S Ferrini, M Fabbi
Cancers, 2021-08-09;13(16):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy
Authors: AL Fisher, V Sangkhae, K Balušíková, NJ Palaskas, T Ganz, E Nemeth
Nature Communications, 2021-06-29;12(1):4026.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors: LG Lima, S Ham, H Shin, EPZ Chai, ESH Lek, RJ Lobb, AF Müller, S Mathivanan, B Yeo, Y Choi, BS Parker, A Möller
Nature Communications, 2021-06-10;12(1):3543.
Species: Human
Sample Types: Exosomes
Applications: ELISA Capture

An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism
Authors: P Gonzalez-M, M Romano, H Yan, R Deshmukh, J Papoin, L Oburoglu, M Daumur, AS Dumé, I Phadke, C Mongellaz, X Qu, PN Bories, M Fontenay, X An, V Dardalhon, M Sitbon, VS Zimmermann, PG Gallagher, S Tardito, L Blanc, N Mohandas, N Taylor, S Kinet
Cell Reports, 2021-02-02;34(5):108723.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses
Authors: H Gunawardan, T Romero, N Yao, S Heidt, A Mulder, DA Elashoff, NM Valenzuela
Scientific Reports, 2021-01-21;11(1):1949.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL?6 plays a crucial role in epithelial?mesenchymal transition and pro?metastasis induced by sorafenib in liver cancer
Authors: KW Zhang, D Wang, H Cai, MQ Cao, YY Zhang, PY Zhuang, J Shen
Oncology reports, 2021-01-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
Authors: J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja
Nature Communications, 2021-01-04;12(1):66.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
Authors: J Stebbing, G Sánchez Ni, M Falcone, S Youhanna, P Richardson, S Ottaviani, JX Shen, C Sommerauer, G Tiseo, L Ghiadoni, A Virdis, F Monzani, LR Rizos, F Forfori, A Avendaño-C, S De Marco, L Carrozzi, F Lena, PM Sánchez-Ju, LG Lacerenza, N Cesira, D Caldevilla, A Perrella, L Niccoli, LS Méndez, D Matarrese, D Goletti, YJ Tan, V Monteil, G Dranitsari, F Cantini, A Farcomeni, S Dutta, SK Burley, H Zhang, M Pistello, W Li, M Mas Romero, F Andrés Pre, RS Simón-Tale, R García-Mol, C Kutter, JH Felce, ZF Nizami, AG Miklosi, JM Penninger, F Menichetti, A Mirazimi, P Abizanda, VM Lauschke
Sci Adv, 2021-01-01;0(0):.
Species: Human
Sample Types: Spheroid
Applications: Spheroid Culture

Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation
Authors: A Dorronsoro, V Lang, I Ferrin, J Fernández-, L Zabaleta, E Pérez-Ruiz, P Sepúlveda, C Trigueros
Scientific Reports, 2020-12-14;10(1):21853.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma
Authors: L Gan, H Shen, X Li, Z Han, Y Jing, X Yang, M Wu, Y Xia
Oncol Rep, 2020-11-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells to inhibit SARS-CoV-2 infection and COVID-19 disease progression
Authors: SA Sheehan, KL Hamilton, EP Retzbach, P Balachandr, H Krishnan, P Leone, GS Goldberg
Res Sq, 2020-10-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity
Authors: L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe
Sci Rep, 2020-10-15;10(1):17444.
Species: Human
Sample Types: Reference Standard

NF-&kappaB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC
Authors: Q Zhang, Z Yang, Y Ni, H Bai, Q Han, Z Yi, X Yi, YL Agbana, Y Kuang, Y Zhu
Cancer Cell Int, 2020-10-06;20(0):483.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE
Authors: M Kurte, AM Vega-Lette, P Luz-Crawfo, F Djouad, D Noël, M Khoury, F Carrión
Stem Cell Res Ther, 2020-09-25;11(1):416.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A role for annexin A2 in scaffolding the peroxiredoxin 2-STAT3 redox relay complex
Authors: D Talwar, J Messens, TP Dick
Nature Communications, 2020-09-09;11(1):4512.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The innate immunity protein IFITM3 modulates &gamma-secretase in Alzheimer's disease
Authors: JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, Y Zhai, JC Wang, J Tcw, L Guo, A McKenzie, C Ming, X Zhou, M Wang, Y Sagi, AE Renton, BT Esposito, Y Kim, KR Sadleir, I Trinh, RA Rissman, R Vassar, B Zhang, DS Johnson, E Masliah, P Greengard, A Goate, YM Li
Nature, 2020-09-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
Cell Rep, 2020-06-30;31(13):107820.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera
Authors: JL Spivak, A Merchant, DM Williams, O Rogers, W Zhao, A Duffield, LS Resar, AR Moliterno, ZJ Zhao
PLoS ONE, 2020-06-01;15(6):e0232801.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES)
Authors: MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee
Biomed J, 2020-05-29;0(0):.
Species: Human
Sample Types: Cells
Applications: Bioassay

Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes
Authors: MF Abas?yan?k, K Wolfe, H Van Phan, J Lin, B Laxman, SR White, PA Verhoef, GM Mutlu, B Patel, S Tay
Nat Commun, 2020-05-25;11(1):2607.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells
Authors: J Kanasugi, I Hanamura, A Ota, S Karnan, VQ Lam, S Mizuno, M Wahiduzzam, ML Rahman, T Hyodo, H Konishi, S Tsuzuki, Y Hosokawa, A Takami
Cancer Sci., 2020-04-09;111(5):1663-1675.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma
Authors: H Xiang, CP Ramil, J Hai, C Zhang, H Wang, AA Watkins, R Afshar, P Georgiev, MA Sze, XS Song, PJ Curran, M Cheng, JR Miller, D Sun, A Loboda, Y Jia, LY Moy, A Chi, PE Brandish
Cancer Immunol Res, 2020-02-19;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5
Authors: T Mang, S Lindemann, A Gigout
Int J Mol Sci, 2020-01-14;21(2):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
Cell Stem Cell, 2020;27(1):125-136.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells
Authors: JE Lee, X Zhong, JY Lee, YJ Surh, HK Na
Arch. Biochem. Biophys., 2019-12-24;0(0):108162.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
Authors: D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally
Cell Rep, 2019-12-24;29(13):4389-4406.e10.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4
Authors: JS Hook, M Cao, K Weng, N Kinnare, JG Moreland
J. Immunol., 2019-12-23;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Standard

Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen
Authors: D De Silva, Z Zhang, Y Liu, JS Parker, C Xu, L Cai, GG Wang, HS Earp, YE Whang
Sci Rep, 2019-12-09;9(1):18637.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer
Authors: X Sun, Q Qu, Y Lao, M Zhang, X Yin, H Zhu, Y Wang, J Yang, J Yi, M Hao
BMC Cancer, 2019-12-03;19(1):1180.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Standard

Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum
Authors: A Stumpf, T Brandstett, J Hübner, J Rühe
PLoS ONE, 2019-12-02;14(12):e0225525.
Species: Human
Sample Types: Serum
Applications: ELISA Standard

Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation
Authors: N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto
Sci Rep, 2019-11-26;9(1):17558.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P

MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness
Authors: JY Ko, WS Lian, TC Tsai, YS Chen, CK Hsieh, CW Kuo, FS Wang
Int J Mol Sci, 2019-11-15;20(22):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models
Authors: AT Stefka, D Johnson, S Rosebeck, JH Park, Y Nakamura, AJ Jakubowiak
Cancer Med, 2019-11-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues
Authors: X Xu, H Fukui, Y Ran, X Wang, Y Inoue, N Ebisudani, H Nishimura, T Tomita, T Oshima, J Watari, H Kiyama, H Miwa
Mediators Inflamm., 2019-11-06;2019(0):7859460.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice
Authors: Z Liu, GWD Easson, J Zhao, N Makki, N Ahituv, MJ Hilton, SY Tang, RS Gray
PLoS Genet., 2019-10-25;15(10):e1008096.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
Authors: J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen
Nat Commun, 2019-10-24;10(1):4856.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals
Authors: ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa
PLoS Pathog., 2019-10-14;15(10):e1008074.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HIF1alpha inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
Authors: C Liang, J Li, C Lu, D Xie, J Liu, C Zhong, X Wu, R Dai, H Zhang, D Guan, B Guo, B He, F Li, X He, W Zhang, BT Zhang, G Zhang, A Lu
Nat Commun, 2019-10-08;10(1):4579.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Possible Role of Neutrophils in the Induction of Osteoclastogenesis
Authors: CGJ Moonen, TJ de Vries, P Rijkschroe, PE Poubelle, EA Nicu, BG Loos
J Immunol Res, 2019-09-15;2019(0):8672604.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells
Authors: Y Yang, W Wang, H Chang, Z Han, X Yu, T Zhang
J. Cell. Mol. Med., 2019-09-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

STAT3-inhibitory activity of sesquiterpenoids and diterpenoids from Curcuma phaeocaulis
Authors: HJ Jang, HJ Lim, EJ Park, SJ Lee, S Lee, SW Lee, MC Rho
Bioorg. Chem., 2019-09-10;93(0):103267.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination
Authors: SK Horrevorts, DA Stolk, RV Ven, M Hulst, BVH Hof, S Duinkerken, MH Heineke, W Ma, SA Dusoswa, R Nieuwland, JJ Garcia-Val, AAV Loosdrecht, TD de Gruijl, SJV Vliet, Y van Kooyk
Cancers (Basel), 2019-08-28;11(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
Authors: MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins
Cell Stem Cell, 2019-08-01;25(2):258-272.e9.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients
Authors: M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa
Haematologica, 2019-06-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
Authors: D Kim, R Chen, M Sheu, N Kim, S Kim, N Islam, EM Wier, G Wang, A Li, A Park, W Son, B Evans, V Yu, VP Prizmic, E Oh, Z Wang, J Yu, W Huang, NK Archer, Z Hu, N Clemetson, AM Nelson, A Chien, GA Okoye, LS Miller, G Ghiaur, S Kang, JW Jones, MA Kane, LA Garza
Nat Commun, 2019-06-26;10(1):2811.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lipocalin 2: A New Antimicrobial in Mast Cells
Authors: YL Chang, Z Wang, S Igawa, JE Choi, T Werbel, A Di Nardo
Int J Mol Sci, 2019-05-14;20(10):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells
Authors: AK Mishra, D Dingli
Leukemia, 2019-04-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
Cell Rep, 2019-04-09;27(2):599-615.e12.
Species: Human
Sample Types: cell culture
Applications: Differentiation, Differentiation

Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1
Authors: J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard
EBioMedicine, 2019-04-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
Authors: C Wei, C Yang, S Wang, D Shi, C Zhang, X Lin, Q Liu, R Dou, B Xiong
Mol. Cancer, 2019-03-30;18(1):64.
Species: Human
Sample Types: Whole Cells

Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
Eur. J. Immunol., 2019-03-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
Cell Death Dis, 2019-03-20;10(4):274.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression
Authors: KC Doh, BM Kim, KW Kim, BH Chung, CW Yang
BMC Complement Altern Med, 2019-03-04;19(1):54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
Cytokine, 2019-03-01;117(0):84-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I
Authors: M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue
Stem Cell Res, 2019-02-12;36(0):101406.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway
Authors: H Xu, SJ Xu, SJ Xie, Y Zhang, JH Yang, WQ Zhang, MN Zheng, H Zhou, LH Qu
Elife, 2019-02-08;8(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
Authors: TA Ahmed, C Adamopoulo, Z Karoulia, X Wu, R Sachidanan, SA Aaronson, PI Poulikakos
Cell Rep, 2019-01-02;26(1):65-78.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An integration-free iPSC line (MUSIi008-A) derived from a patient with severe hemolytic anemia carrying compound heterozygote mutations in KLF1 gene for disease modeling
Authors: P Potirat, M Wattanapan, V Viprakasit, P Kheolamai, S Issaragris
Stem Cell Res, 2018-12-14;34(0):101344.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts
Authors: S Yamamoto, K Omori, H Mandai, M Nakayama, S Nakagawa, H Kobayashi, T Kunimine, H Yoshimura, K Sakaida, H Sako, S Ibaragi, T Yamamoto, H Maeda, S Suga, S Takashiba
Heliyon, 2018-11-26;4(11):e00979.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of TNF-? and interleukin-6 in seroma of patients undergoing mastectomy with or without flap fixation: is there a predictive value for seroma formation and its sequelae?
Authors: J van Bastel, R Granzier, LM van Roozen, SMJ van Kuijk, AV Lerut, G Beets, M Hadfoune, S Olde Damin, YLJ Vissers
Surg Oncol, 2018-11-08;28(0):36-41.
Species: Human
Sample Types: Complex Sample Type
Applications: ELISA (Standard)

Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells
Authors: S Tomi?, N Ili?, V Kokol, A Gruden-Mov, D Mihajlovi?, M Beki?, L Sofroni?-M, M ?oli?, D Vu?evi?
Int J Nanomedicine, 2018-10-31;13(0):6941-6960.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Copy number variations and founder effect underlying complete IL-10R? deficiency in Portuguese kindreds
Authors: F Charbit-He, B Bègue, A Sierra, S Hanein, MC Stolzenber, Z Li, S Pellegrini, N Garcelon, M Jeanpierre, B Neven, I Loge, C Picard, J Rosain, J Bustamante, M Le Lorc'h, B Pigneur, A Fernandes, F Rieux-Lauc, J Amil Dias, FM Ruemmele, N Cerf-Bensu
PLoS ONE, 2018-10-26;13(10):e0205826.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma
Authors: U Painuly, V Ramakrishn, T Kimlinger, L Wellik, J Haug, W Gonsalves, L Bi, Z Huang, SV Rajkumar, S Kumar
Oncotarget, 2018-10-02;9(77):34582-34594.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop
Authors: M Zhong, Z Huang, L Wang, Z Lin, Z Cao, X Li, F Zhang, H Wang, Y Li, X Ma
Sci Rep, 2018-09-05;8(1):13291.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Abnormally Expressed JunB Transactivated by IL-6/STAT3 Signaling Promotes Uveal Melanoma Aggressiveness via Epithelial-mesenchymal Transition
Authors: C Gong, J Shen, Z Fang, L Qiao, R Feng, X Lin, S Li
Biosci. Rep., 2018-07-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice
Authors: X Jin, X He, X Cao, P Xu, Y Xing, S Sui, L Wang, J Meng, W Lu, R Cui, H Ni, M Zhao
Haematologica, 2018-06-14;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation
Authors: JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani
Cell Death Dis, 2018-06-04;9(6):665.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Synergistic effect of interleukin-17 and tumor necrosis factor-α on inflammatory response in hepatocytes through interleukin-6 dependent and independent pathways
Authors: A Beringer, N Thiam, J Molle, B Bartosch, P Miossec
Clin. Exp. Immunol., 2018-05-31;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anisakis pegreffii impacts differentiation and function of human dendritic cells
Authors: C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti
Parasite Immunol., 2018-05-01;0(0):e12527.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development
Authors: M Cesana, MH Guo, D Cacchiarel, L Wahlster, J Barragan, S Doulatov, LT Vo, B Salvatori, C Trapnell, K Clement, P Cahan, KM Tsanov, PM Sousa, B Tazon-Vega, A Bolondi, FM Giorgi, A Califano, JL Rinn, A Meissner, JN Hirschhorn, GQ Daley
Cell Stem Cell, 2018-04-05;22(4):575-588.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment
Authors: S Kotha, S Sun, A Adams, B Hayes, KT Phong, R Nagao, JA Reems, D Gao, B Torok-Stor, JA López, Y Zheng
PLoS ONE, 2018-04-04;13(4):e0195082.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica
Authors: R Wilson, M Makuch, AK Kienzler, J Varley, J Taylor, M Woodhall, J Palace, MI Leite, P Waters, SR Irani
Brain, 2018-04-01;141(4):1063-1074.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
Authors: A Klaesson, K Grannas, T Ebai, J Heldin, B Koos, M Leino, D Raykova, J Oelrich, L Arngården, O Söderberg, U Landegren
Sci Rep, 2018-03-29;8(1):5400.
Species: Human
Sample Types: Recombinant Protein
Applications: Proximity Ligation Assay (PLA)

Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes
Authors: J Lucifora, M Bonnin, L Aillot, F Fusil, S Maadadi, L Dimier, M Michelet, O Floriot, A Ollivier, M Rivoire, M Ait-Gougho, S Daffis, SP Fletcher, A Salvetti, FL Cosset, F Zoulim, D Durantel
Sci Rep, 2018-03-29;8(1):5390.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis
Authors: H Pei, L He, M Shao, Z Yang, Y Ran, D Li, Y Zhou, M Tang, T Wang, Y Gong, X Chen, S Yang, M Xiang, L Chen
Sci Rep, 2018-03-27;8(1):5273.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cytokine Profile of Human Abdominal Aortic Aneurysm: Involvement of JAK/STAT Pathway
Authors: T Ohno, H Aoki, S Ohno, M Nishihara, A Furusho, S Hiromatsu, H Akashi, Y Fukumoto, H Tanaka
Ann Vasc Dis, 2018-03-25;11(1):84-90.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway
Authors: M Jiang, Y Wang, H Zhang, Y Ji, P Zhao, R Sun, C Zhang
Thorac Cancer, 2018-03-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A novel mechanism of ?-irradiation-induced IL-6 production mediated by P2Y11 receptor in epidermal keratinocytes
Authors: A Ohsaki, Y Miyano, R Tanaka, SI Tanuma, S Kojima, M Tsukimoto
Biol. Pharm. Bull., 2018-03-16;0(0):.
Applications: ELISA (Standard)

Molecular transitions in early progenitors during human cord blood hematopoiesis
Authors: S Zheng, E Papalexi, A Butler, W Stephenson, R Satija
Mol. Syst. Biol., 2018-03-15;14(3):e8041.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism
Authors: JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang
Blood, 2018-03-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection
Authors: CB Ching, S Gupta, B Li, H Cortado, N Mayne, AR Jackson, KM McHugh, B Becknell
Kidney Int., 2018-02-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials
Authors: H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi
Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway
Authors: F Zhang, G Liu, D Li, C Wei, J Hao
J. Immunol., 2018-01-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies
Authors: R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson
Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):.
Applications: Bioassay

Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis
Authors: H Alsaffar, N Martino, JP Garrett, AP Adam
Am. J. Physiol., Cell Physiol., 2018-01-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model
Authors: K Schmitt, P Charlins, M Veselinovi, L Kinner-Bib, S Hu, J Curlin, L Remling-Mu, KE Olson, T Aboellail, R Akkina
Virology, 2018-01-06;515(0):235-242.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells
Authors: YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo
PLoS ONE, 2018-01-03;13(1):e0190638.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes
Authors: A Palau, AK Garz, J Diesch, A Zwick, R Malinverni, V Valero, K Lappin, R Casquero, A Lennartsso, J Zuber, T Navarro, KI Mills, KS Götze, M Buschbeck
Oncotarget, 2017-12-01;8(70):115002-115017.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G6PD promotes renal cell carcinoma proliferation through positive feedback regulation of p-STAT3
Authors: Q Zhang, Z Yang, Q Han, H Bai, Y Wang, X Yi, Z Yi, L Yang, L Jiang, X Song, Y Kuang, Y Zhu
Oncotarget, 2017-11-20;8(65):109043-109060.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
Authors: GE Tyzack, CE Hall, CR Sibley, T Cymes, S Forostyak, G Carlino, IF Meyer, G Schiavo, SC Zhang, GM Gibbons, J Newcombe, R Patani, A Lakatos
Nat Commun, 2017-10-27;8(1):1164.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
Authors: Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang
J. Immunol., 2017-09-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments
Authors: S Radecke, K Schwarz, F Radecke
Mol. Ther., 2017-09-15;26(1):115-131.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models
Authors: A Steinert, I Linas, B Kaya, M Ibrahim, A Schlitzer, P Hruz, K Radulovic, L Terraccian, AJ Macpherson, JH Niess
J. Immunol., 2017-09-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
Cell Rep, 2017-08-15;20(7):1597-1608.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling
Authors: HP Hsu, MD Lai, JC Lee, MC Yen, TY Weng, WC Chen, JH Fang, YL Chen
Sci Rep, 2017-07-19;7(1):5823.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A
Authors: A Bott, N Erdem, S Lerrer, A Hotz-Wagen, C Breunig, K Abnaof, A Wörner, H Wilhelm, E Münsterman, A Ben-Baruch, S Wiemann
Oncotarget, 2017-07-04;8(27):43897-43914.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study
Authors: JH von Steman, AS Rigas, LW Thørner, DGK Rasmussen, OB Pedersen, K Rostgaard, C Erikstrup, H Ullum, MB Hansen
PLoS ONE, 2017-06-30;12(6):e0179981.
Species: Human
Sample Types: Plasma
Applications: Control

TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
J. Immunol., 2017-06-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Knockout of the Nogo-B Gene Attenuates Tumor Growth and Metastasis in Hepatocellular Carcinoma
Authors: B Zhu, S Chen, X Hu, X Jin, Y Le, L Cao, Z Yuan, Z Lin, S Jiang, L Sun, L Yu
Neoplasia, 2017-06-17;19(7):583-593.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
Authors: E Forcade, K Paz, R Flynn, B Griesenaue, T Amet, W Li, L Liu, G Bakoyannis, D Jiang, HW Chu, M Lobera, J Yang, DS Wilkes, J Du, K Gartlan, GR Hill, KP MacDonald, EL Espada, P Blanco, JS Serody, J Koreth, CS Cutler, JH Antin, RJ Soiffer, J Ritz, S Paczesny, BR Blazar
JCI Insight, 2017-06-15;2(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

?2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine
Authors: A Mayati, A Moreau, C Denizot, B Stieger, Y Parmentier, O Fardel
Eur J Pharm Sci, 2017-06-08;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
Nat. Immunol., 2017-05-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-1? transcriptionally activates hepcidin by inducing C/EBP? expression in hepatocytes
Authors: Y Kanamori, M Murakami, M Sugiyama, O Hashimoto, T Matsui, M Funaba
J. Biol. Chem., 2017-04-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway
Authors: D Wang, S Tang, Q Zhang
Oncol Lett, 2017-04-21;13(6):4875-4881.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In�vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells
Authors: Y Kokubu, T Yamaguchi, K Kawabata
Biochem. Biophys. Res. Commun, 2017-03-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Autophagy Impairment by Helicobacter pylori-induced Methylation Silencing of MAP1LC3Av1 Promotes Gastric Carcinogenesis
Authors: JS Muhammad, S Nanjo, T Ando, S Yamashita, T Maekita, T Ushijima, Y Tabuchi, T Sugiyama
Int. J. Cancer, 2017-03-14;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9
Authors: JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski
J. Immunol, 2017-03-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
Sci Rep, 2017-03-02;7(0):43736.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance
Authors: AS Pachori, M Madan, YO Nunez Lope, F Yi, C Meyer, AA Seyhan
Obesity (Silver Spring), 2017-02-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentation and drives tumor progression
Authors: H Tsukamoto, K Fujieda, M Hirayama, T Ikeda, A Yuno, K Matsumura, D Fukuma, K Araki, H Mizuta, H Nakayama, S Senju, Y Nishimura
Cancer Res, 2017-02-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
Authors: Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang
Am J Transl Res, 2017-02-15;9(2):454-465.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells
Authors: M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney
Clin. Cancer Res, 2017-02-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling
Authors: C Lin, W Liao, Y Jian, Y Peng, X Zhang, L Ye, Y Cui, B Wang, X Wu, Z Xiong, S Wu, J Li, X Wang, L Song
Oncogene, 2017-02-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
Authors: R Adams, RJ Burnley, CR Valenzano, O Qureshi, C Doyle, S Lumb, M Del Carmen, R Griffin, D McMillan, RD Taylor, C Meier, P Mori, LM Griffin, U Wernery, J Kinne, S Rapecki, TS Baker, AD Lawson, M Wright, A Ettorre
Sci Rep, 2017-01-30;7(0):37716.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1)
Authors: KZ Oben, BW Gachuki, SS Alhakeem, MK McKenna, Y Liang, DK St Clair, VM Rangnekar, S Bondada
PLoS ONE, 2017-01-12;12(1):e0169767.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
Cell Death Dis, 2016-12-29;7(12):e2565.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis
Authors: Anja Kerstein
J. Autoimmun, 2016-12-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
Front Immunol, 2016-12-23;7(0):603.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Injury-Induced Senescence Enables In�Vivo Reprogramming in Skeletal Muscle
Authors: Aurélie Chiche
Cell Stem Cell, 2016-12-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling
Sci Rep, 2016-12-19;6(0):39190.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro
Authors: Yukio Takeshita
Neurol Neuroimmunol Neuroinflamm, 2016-12-19;4(1):e311.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia
Oncogene, 2016-12-19;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database
Drug Des Devel Ther, 2016-12-15;10(0):4091-4100.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
Authors: L J Spicer
Domest. Anim. Endocrinol, 2016-12-11;59(0):90-99.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

A generic RNA pulsed DC based approach for developing therapeutic intervention against Nasopharyngeal Carcinoma
Authors: Rajeev K Tyagi
Hum Vaccin Immunother, 2016-11-30;0(0):0.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation
Authors: Andrea Todisco
Am. J. Physiol. Gastrointest. Liver Physiol., 2016-11-17;0(0):ajpgi.00169.2.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population
Authors: Derek N J Hart
J. Immunol., 2016-11-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
Authors: Robert Sabat
Mediators Inflamm., 2016-10-23;2016(0):4097574.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?
Aging Cell, 2016-09-22;0(0):.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha
J Neurosci, 2016-09-21;36(38):9782-91.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation
J Biol Chem, 2016-09-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue
J Immunol, 2016-09-19;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Cytokines TNF-?, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells.
Authors: Angela P Bastidas-C, Astrid D Bakker, Behrouz Zandieh-D, Cornelis J Kleverlaa, Nathalie Bravenboe, Tim Forouzanf, Jenneke Klein-Nul
Stem Cells International, 2016-09-07;0(0):1687-966X.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of Polycystin-1 Function by Calmodulin Binding
PLoS ONE, 2016-08-25;11(8):e0161525.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jak1-STAT3 signals are essential effectors of the USP6/TRE17 oncogene in tumorigenesis
Cancer Res, 2016-07-20;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus
Authors: Olaf Pinkenburg
PLoS ONE, 2016-06-06;11(6):e0156929.
Species: Human
Sample Types: Whole Cells
Applications: ELISA (Standard)

Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor
Authors: Marcin Ratajewski
J Leukoc Biol, 2016-06-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7
Authors: MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker
Stem Cells Dev., 2016-05-02;25(10):774-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors.
Authors: Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, Chang Y, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice D, Clouthier S, Xiao Z, Wicha M, Korkaya H, Hollingsworth R
Cancer Res, 2016-01-07;76(2):480-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cryptococcus gattii Capsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing.
Authors: Huston S, Ngamskulrungroj P, Xiang R, Ogbomo H, Stack D, Li S, Timm-McCann M, Kyei S, Oykhman P, Kwon-Chung K, Mody C
J Immunol, 2016-01-06;196(3):1259-71.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis
Authors: BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee
J. Biol. Chem, 2015-12-23;291(8):4048-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-kappaB.
Authors: Min H, Kim S, Baek S, Woo J, Park J, Cho M, Lee J, Kwok S, Kim S, Park S
PLoS ONE, 2015-11-06;10(11):e0138201.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate Cancer.
Authors: Dong B, Shi Z, Wang J, Wu J, Yang Z, Fang K
PLoS ONE, 2015-08-07;10(8):e0134366.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
Authors: Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D
J Transl Med, 2015-06-20;13(0):197.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-6 Stimulates Defective Angiogenesis.
Authors: Gopinathan G, Milagre C, Pearce O, Reynolds L, Hodivala-Dilke K, Leinster D, Zhong H, Hollingsworth R, Thompson R, Whiteford J, Balkwill F
Cancer Res, 2015-06-16;75(15):3098-107.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy.
Authors: Schumacher A, Denecke B, Braunschweig T, Stahlschmidt J, Ziegler S, Brandenburg L, Stope M, Martincuks A, Vogt M, Gortz D, Camporeale A, Poli V, Muller-Newen G, Brummendorf T, Ziegler P
J Hematol Oncol, 2015-06-09;8(0):64.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor beta Subunit, Glycoprotein 130.
Authors: Hong S, Choi J, Lee S, Park Y, Park K, Lee J, Kim J, Gajulapati V, Goo J, Singh S, Lee K, Kim Y, Im S, Ahn S, Rose-John S, Heo T, Choi Y
J Immunol, 2015-05-29;195(1):237-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
Authors: Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A
J Exp Med, 2015-04-27;212(5):619-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
Authors: Kim J, Tillu D, Quinn T, Mejia G, Shy A, Asiedu M, Murad E, Schumann A, Totsch S, Sorge R, Mantyh P, Dussor G, Price T
J Neurosci, 2015-04-22;35(16):6307-17.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
Authors: Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J
Nat Med, 2015-04-20;21(5):530-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
Authors: Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
PLoS ONE, 2015-04-10;10(4):e0123232.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Impaired T cell responsiveness to interleukin-6 in hematological patients with invasive aspergillosis.
Authors: Camargo J, Bhimji A, Kumar D, Kaul R, Pavan R, Schuh A, Seftel M, Lipton J, Gupta V, Humar A, Husain S
PLoS ONE, 2015-04-02;10(4):e0123171.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.
Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
Stem Cells, 2015-04-01;33(4):1142-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
PLoS ONE, 2015-03-25;10(3):e0122149.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molecular mechanisms linking high dose medroxyprogesterone with HIV-1 risk.
Authors: Irvin S, Herold B
PLoS ONE, 2015-03-23;10(3):e0121135.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.
Authors: Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A
PLoS ONE, 2015-03-18;10(3):e0119415.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.
Authors: Gentilini M, Velasquez L, Barrionuevo P, Arriola Benitez P, Giambartolomei G, Delpino M
Infect Immun, 2015-03-02;83(5):1973-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease
Authors: James B Canavan
Gut, 2015-02-24;65(4):584-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RelB/p50 complexes regulate cytokine-induced YKL-40 expression.
Authors: Bhardwaj R, Yester J, Singh S, Biswas D, Surace M, Waters M, Hauser K, Yao Z, Boyce B, Kordula T
J Immunol, 2015-02-13;194(6):2862-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
Respir Res, 2015-02-07;16(0):14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
Authors: Herova M, Schmid M, Gemperle C, Hersberger M
J Immunol, 2015-01-30;194(5):2330-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma.
Authors: Fichtner S, Hose D, Engelhardt M, Meissner T, Neuber B, Krasniqi F, Raab M, Schonland S, Ho A, Goldschmidt H, Hundemer M
Clin Cancer Res, 2015-01-21;21(7):1712-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.
Authors: Goedken E, Argiriadi M, Banach D, Fiamengo B, Foley S, Frank K, George J, Harris C, Hobson A, Ihle D, Marcotte D, Merta P, Michalak M, Murdock S, Tomlinson M, Voss J
J Biol Chem, 2014-12-31;290(8):4573-89.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.
Authors: Venkatesha V, Joshi A, Venkataraman M, Sonawane V, Bhatia D, Tannu P, Bose J, Choudhari S, Srivastava A, Pandey P, Lad V, Sangana R, Ahmed T, Damre A, Deore V, Sahu B, Kumar S, Sharma S, Agarwal V
Mol Cancer, 2014-12-02;13(0):259.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling.
Authors: Sobotta M, Liou W, Stocker S, Talwar D, Oehler M, Ruppert T, Scharf A, Dick T
Nat Chem Biol, 2014-11-24;11(1):64-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.
Authors: Lee D, Sung K, Bartlett D, Kwon Y, Lee Y
Cell Signal, 2014-11-18;27(2):293-305.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
Mol Ther, 2014-11-04;23(2):387-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator.
Authors: Zhu H, Han C, Lu D, Wu T
Am J Pathol, 2014-10-01;184(10):2828-39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.
Authors: Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M
Cancer Res, 2014-09-30;74(24):7418-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability.
Authors: Davaine J, Quillard T, Brion R, Laperine O, Guyomarch B, Merlini T, Chatelais M, Guilbaud F, Brennan M, Charrier C, Heymann D, Goueffic Y, Heymann M
PLoS ONE, 2014-09-26;9(9):e107642.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
Authors: Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L
J Clin Invest, 2014-09-17;124(10):4657-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
PLoS ONE, 2014-09-03;9(9):e106673.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Direct crosstalk between cancer and osteoblast lineage cells fuels metastatic growth in bone via auto-amplification of IL-6 and RANKL signaling pathways.
Authors: Zheng Y, Chow S, Boernert K, Basel D, Mikuscheva A, Kim S, Fong-Yee C, Trivedi T, Buttgereit F, Sutherland R, Dunstan C, Zhou H, Seibel M
J Bone Miner Res, 2014-09-01;29(9):1938-49.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells.
Authors: Kwon, Sang-Mo, Lee, Jun-Hee, Lee, Sang-Hun, Jung, Seok-Yun, Kim, Da-Yeon, Kang, Song-Hwa, Yoo, So-Young, Hong, Jong-Kyu, Park, Ji-Hye, Kim, Jung-Hee, Kim, Sung-Woo, Kim, Yeon-Ju, Lee, Sun-Jin, Kim, Hwi-Gon, Asahara, Takayuki
PLoS ONE, 2014-08-28;9(8):e106310.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector.
Authors: Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou M, Chan J
PLoS ONE, 2014-08-12;9(8):e104805.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors.
Authors: Anderson J, Titz B, Akiyama R, Komisopoulou E, Park A, Tap W, Graeber T, Denny C
Mol Cancer Res, 2014-08-04;12(12):1740-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of Bruton's tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells.
Authors: Bam R, Venkateshaiah S, Khan S, Ling W, Randal S, Li X, Zhang Q, van Rhee F, Barlogie B, Epstein J, Yaccoby S
Blood Cancer J, 2014-08-01;4(0):e234.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
J Immunol, 2014-07-30;193(5):2297-305.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex.
Authors: Zhang Q, Yang Z, Jia Z, Liu C, Guo C, Lu H, Chen P, Ma K, Wang W, Zhou C
Mol Cancer, 2014-07-29;13(0):181.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells.
Authors: Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B
J Biol Chem, 2014-07-28;289(37):25546-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive.
Authors: O'Toole A, Michielsen A, Nolan B, Tosetto M, Sheahan K, Mulcahy H, Winter D, Hyland J, O'Connell P, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty G, Ryan E
Br J Cancer, 2014-07-24;111(5):927-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Filarial excretory-secretory products induce human monocytes to produce lymphangiogenic mediators.
Authors: Weinkopff T, Mackenzie C, Eversole R, Lammie P
PLoS Negl Trop Dis, 2014-07-10;8(7):e2893.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Authors: Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, Dussor G, Price T
Mol Pain, 2014-07-04;10(0):45.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.
Authors: Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M
Blood, 2014-07-02;124(9):1393-403.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
Authors: Kastrati I, Canestrari E, Frasor J
Oncogene, 2014-06-23;34(18):2309-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.
Authors: Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer M, Zhang H, Hogquist K, Evavold B, Vignali D
J Immunol, 2014-06-18;193(2):571-9.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens).
Authors: Tanaka, Akinobu, Zhu, Qinchang, Tan, Hui, Horiba, Hiroki, Ohnuki, Koichiro, Mori, Yasuhiro, Yamauchi, Ryoko, Ishikawa, Hiroya, Iwamoto, Akira, Kawahara, Hiroharu, Shimizu, Kuniyosh
Molecules, 2014-06-18;19(6):8238-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
Cancer Res, 2014-06-16;74(16):4458-69.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.
Authors: Horwitz, Mitchell, Chao, Nelson J, Rizzieri, David A, Long, Gwynn D, Sullivan, Keith M, Gasparetto, Cristina, Chute, John P, Morris, Ashley, McDonald, Carolyn, Waters-Pick, Barbara, Stiff, Patrick, Wease, Steven, Peled, Amnon, Snyder, David, Cohen, Einat Ga, Shoham, Hadas, Landau, Efrat, Friend, Etty, Peleg, Iddo, Aschengrau, Dorit, Yackoubov, Dima, Kurtzberg, Joanne, Peled, Tony
J Clin Invest, 2014-06-09;124(7):3121-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.
Authors: Linher-Melville, Katja, Singh, Gurmit
BMC Cancer, 2014-06-09;14(0):415.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.
Authors: Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V
J Allergy Clin Immunol, 2014-06-06;134(2):373-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta.
Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y
Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells.
Authors: Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit M, Blanchet X, von Hundelshausen P, Weber C, Forssmann W, Henschler R
Stem Cells Dev, 2014-05-27;23(16):1959-74.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
J Clin Invest, 2014-05-08;124(6):2513-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
Authors: Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C
PLoS ONE, 2014-05-02;9(5):e96695.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.
Authors: Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S
Stem Cells, 2014-05-01;32(5):1337-46.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish.
Authors: Bu Y, Su F, Wang X, Gao H, Lei L, Chang N, Wu Q, Hu K, Zhu X, Chang Z, Meng K, Xiong J
J Cell Sci, 2014-04-11;127(0):2761-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.
Authors: Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S, Marshall D, Moore A, Neale H, Lawson A
MAbs, 2014-04-02;6(3):774-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene.
Authors: Al-Sadi R, Ye D, Boivin M, Guo S, Hashimi M, Ereifej L, Ma T
PLoS ONE, 2014-03-24;9(3):e85345.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection.
Authors: Umashankar, Mahadeva, Rak, Michael, Bughio, Farah, Zagallo, Patricia, Caviness, Katie, Goodrum, Felicia
J Virol, 2014-03-12;88(11):5987-6002.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.
Authors: Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S
PLoS ONE, 2014-03-04;9(3):e89064.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells.
Authors: Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H
Int J Oncol, 2014-02-21;44(5):1643-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.
Authors: Di Martino M, Gulla A, Gallo Cantafio M, Altomare E, Amodio N, Leone E, Morelli E, Lio S, Caracciolo D, Rossi M, Frandsen N, Tagliaferri P, Tassone P
PLoS ONE, 2014-02-21;9(2):e89659.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
Authors: O'Reilly S, Ciechomska M, Cant R, van Laar J
J Biol Chem, 2014-02-18;289(14):9952-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
Eur J Immunol, 2014-02-18;44(5):1330-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells.
Authors: Valle Oseguera, Cendy A, Spencer, Juliet V
PLoS ONE, 2014-02-10;9(2):e88708.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anti-beta(2)M monoclonal antibodies kill myeloma cells via cell- and complement-mediated cytotoxicity.
Authors: Zhang M, Qian J, Lan Y, Lu Y, Li H, Hong B, Zheng Y, He J, Yang J, Yi Q
Int J Cancer, 2014-02-07;135(5):1132-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
Authors: Milwid, Jack M, Elman, Jessica, Li, Matthew, Shen, Keyue, Manrai, Arjun, Gabow, Aaron, Yarmush, Joshua, Jiao, Yunxin, Fletcher, Anne, Lee, Jungwoo, Cima, Michael, Yarmush, Martin L, Parekkadan, Biju
Mol Ther, 2014-02-05;22(5):999-1007.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells.
Authors: Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L
J Leukoc Biol, 2014-02-03;95(6):893-901.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-beta.
Authors: Mele V, Muraro M, Calabrese D, Pfaff D, Amatruda N, Amicarella F, Kvinlaug B, Bocelli-Tyndall C, Martin I, Resink T, Heberer M, Oertli D, Terracciano L, Spagnoli G, Iezzi G
Int J Cancer, 2014-01-30;134(11):2583-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation.
Authors: Imai F, Kishi H, Nakao K, Nishimura T, Minegishi T
Endocrinology, 2014-01-27;155(4):1436-44.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Digital microfluidic assay for protein detection.
Authors: Mok J, Mindrinos M, Davis R, Javanmard M
Proc Natl Acad Sci U S A, 2014-01-21;111(6):2110-5.
Species: N/A
Sample Types: Antibody
Applications: Bioassay, ELISA Standard

Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.
Authors: Gupta, Shashi, Hirota, Masao, Waugh, Sheela M, Murakami, Ikuo, Suzuki, Tomoki, Muraguchi, Masahiro, Shibamori, Masafumi, Ishikawa, Yuichi, Jarvis, Thale C, Carter, Jeffrey, Zhang, Chi, Gawande, Bharat, Vrkljan, Michael, Janjic, Nebojsa, Schneider, Daniel J
J Biol Chem, 2014-01-12;289(12):8706-19.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets.
Authors: McCutcheon, Krista M, Gray, Julia, Chen, Natalie, Liu, Keyi, Park, Minha, Ellsworth, Stote, Tripp, Ralph A, Tompkins, S Mark, Johnson, Scott K, Samet, Shelly, Pereira, Lenore, Kauvar, Lawrence
MAbs, 2014-01-08;6(2):460-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.
Authors: Suzuki, Hitoshi, Raska, Milan, Yamada, Koshi, Moldoveanu, Zina, Julian, Bruce A, Wyatt, Robert J, Tomino, Yasuhiko, Gharavi, Ali G, Novak, Jan
J Biol Chem, 2014-01-07;289(8):5330-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.
Authors: Mleczko-Sanecka K, Roche F, Da Silva A, Call D, D'Alessio F, Ragab A, Lapinski P, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro L, Klingmuller U, King P, Boutros M, Hentze M, Muckenthaler M
Blood, 2014-01-02;123(10):1574-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.
Authors: Rodin S, Antonsson L, Niaudet C, Simonson O, Salmela E, Hansson E, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson A, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjold M, Grinnemo K, Kere J, Betsholtz C, Hovatta O, Tryggvason K
Nat Commun, 2014-01-01;5(0):3195.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inflammation regulates TMPRSS6 expression via STAT5.
Authors: Meynard, Delphine, Sun, Chia Chi, Wu, Qifang, Chen, Wenjie, Chen, Shanzhuo, Nelson, Caroline, Waters, Michael, Babitt, Jodie L, Lin, Herbert
PLoS ONE, 2013-12-23;8(12):e82127.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Establishment of a bortezomib-resistant Chinese human multiple myeloma cell line: MMLAL.
Authors: Wong, Kwan Yeu, Wan, Thomas S, So, Chi Chiu, Chim, Chor San
Cancer Cell Int, 2013-12-12;13(1):122.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Tropism of avian influenza A (H5N1) virus to mesenchymal stem cells and CD34+ hematopoietic stem cells.
Authors: Thanunchai, Maytawan, Kanrai, Pumaree, Wiboon-Ut, Suwimon, Puthavathana, Pilaipan, Hongeng, Suradej, Thitithanyanont, Arunee
PLoS ONE, 2013-12-10;8(12):e81805.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
J Invest Dermatol, 2013-12-06;134(5):1246-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model.
Authors: Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C
PLoS ONE, 2013-11-18;8(11):e80403.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.
Authors: Csaszar, Elizabet, Wang, Weijia, Usenko, Tatiana, Qiao, Wenlian, Delaney, Colleen, Bernstein, Irwin D, Zandstra, Peter W
Blood, 2013-11-15;123(5):650-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NF-kappaB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.
Authors: McFarland B, Hong S, Rajbhandari R, Twitty G, Gray G, Yu H, Benveniste E, Nozell S
PLoS ONE, 2013-11-11;8(11):e78728.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis.
Authors: Dowty, Martin E, Jesson, Michael, Ghosh, Sarbani, Lee, Jamie, Meyer, Debra M, Krishnaswami, Sriram, Kishore, Nandini
J Pharmacol Exp Ther, 2013-11-11;348(1):165-73.
Species: Mouse
Sample Types: Whole Blood
Applications: Bioassay

The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes.
Authors: Mercier S, Donaghy H, Botting R, Turville S, Harman A, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson R, Moritz R, Cunningham A
PLoS Pathog, 2013-10-17;9(10):e1003700.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays.
Authors: Todd J, Simpson P, Estis J, Torres V, Wub A
Cytokine, 2013-10-12;64(3):660-5.
Species: Human
Sample Types: Plasma
Applications: ELISA (Standard)

Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
Cell Stem Cell, 2013-10-03;13(4):459-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

EGFR inhibition induces proinflammatory cytokines via NOX4 in HNSCC.
Authors: Fletcher E, Love-Homan L, Sobhakumari A, Feddersen C, Koch A, Goel A, Simons A
Mol Cancer Res, 2013-09-18;11(12):1574-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
Authors: Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E
Clin Cancer Res, 2013-09-13;19(23):6484-94.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.
Authors: Minami J, Suzuki R, Mazitschek R, Gorgun G, Ghosh B, Cirstea D, Hu Y, Mimura N, Ohguchi H, Cottini F, Jakubikova J, Munshi N, Haggarty S, Richardson P, Hideshima T, Anderson K
Leukemia, 2013-08-05;28(3):680-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.
Authors: Yoo H, Seo J, Yoo J
PLoS ONE, 2013-04-11;8(4):e61055.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
Arthritis Rheum, 2013-04-01;65(4):949-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state.
Authors: Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, Taylor C, Ghosh S, Price T
Mol Pain, 2013-03-20;9(0):12.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

IL-6-174 G > C and MMP-9-1562 C > T polymorphisms are associated with increased risk of deep vein thrombosis in cancer patients.
Authors: Malaponte G, Polesel J, Candido S, Sambataro D, Bevelacqua V, Anzaldi M, Vella N, Fiore V, Militello L, Mazzarino M, Libra M, Signorelli S
Cytokine, 2013-03-11;62(1):64-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
Authors: El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J
PLoS ONE, 2013-03-08;8(3):e58935.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.
Authors: Leone E, Morelli E, Di Martino M, Amodio N, Foresta U, Gulla A, Rossi M, Neri A, Giordano A, Munshi N, Anderson K, Tagliaferri P, Tassone P
Clin Cancer Res, 2013-02-27;19(8):2096-106.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
Clin Cancer Res, 2013-02-26;19(7):1858-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Protein carbamylation predicts mortality in ESRD.
Authors: Koeth R, Kalantar-Zadeh K, Wang Z, Fu X, Tang W, Hazen S
2013-02-21;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA (Standard)

Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.
Authors: Verjee L, Verhoekx J, Chan J, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood K, Nanchahal J
Proc Natl Acad Sci U S A, 2013-02-19;110(10):E928-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
Authors: Yu, Jianhua, Peng, Yong, Wu, Lai-Chu, Xie, Zhiliang, Deng, Youcai, Hughes, Tiffany, He, Shun, Mo, XiaoKui, Chiu, Ming, Wang, Qi-En, He, Xiaoming, Liu, Shujun, Grever, Michael, Chan, Kenneth, Liu, Zhongfa
PLoS ONE, 2013-02-13;8(2):e55934.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells.
Authors: Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D
Mol Ther, 2013-02-05;21(5):1044-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
Authors: Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J
Hum Mol Genet, 2013-01-31;22(9):1807-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
Authors: Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M
PLoS ONE, 2012-11-21;7(11):e50195.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
Authors: Kothari H, Rao L, Vankayalapati R, Pendurthi U
PLoS ONE, 2012-09-24;7(9):e45700.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
Authors: Zelinka C, Scott M, Volkov L, Fischer A
PLoS ONE, 2012-09-04;7(9):e44477.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

CD4 T follicular helper cell dynamics during SIV infection.
J. Clin. Invest., 2012-08-27;122(9):3281-94.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase.
Authors: Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD
J. Biol. Chem., 2012-06-11;287(31):25964-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta.
Authors: Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
Nature, 2012-04-26;484(7395):514-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Authors: Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
Eur. J. Immunol., 2012-04-01;42(4):936-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
Authors: Wilde S, Geiger C, Milosevic S, Mosetter B, Eichenlaub S, Schendel D
Oncoimmunology, 2012-03-01;1(2):129-140.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Authors: Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK
J Korean Med Sci, 2011-09-01;26(9):1132-9.
Applications: ELISA (Standard)

Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli.
Authors: Von Bubnoff D, Scheler M, Wilms H, Fimmers R, Bieber T
J. Immunol., 2011-05-04;186(12):6701-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
Authors: Liao W, Lin JX, Wang L, Li P, Leonard WJ
Nat. Immunol., 2011-04-24;12(6):551-9.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
Authors: Steinbicker AU, Sachidanandan C, Vonner AJ
Blood, 2011-03-10;117(18):4915-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis.
Authors: Hosomi S, Oshitani N, Kamata N, Sogawa M, Okazaki H, Tanigawa T, Yamagami H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T
Clin. Exp. Immunol., 2010-11-19;163(2):215-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression.
Authors: Xu H, Wang X, Pahar B
J. Immunol., 2010-11-08;185(12):7340-8.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
Authors: Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B
Blood, 2010-10-29;117(3):839-47.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
FASEB J., 2010-09-08;25(1):409-19.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.
Authors: Trowbridge JJ, Guezguez B, Moon RT
Stem Cells, 2010-08-01;28(8):1379-89.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
Authors: Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C
J. Immunol., 2010-07-16;185(0):2516-24.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
Authors: Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G
Blood, 2010-07-06;116(16):3099-107.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.
Authors: Morizane S, Yamasaki K, Kabigting FD, Gallo RL
J. Invest. Dermatol., 2010-01-21;130(5):1297-306.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
Nat. Med., 2010-01-10;16(2):191-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2009-11-12;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
Immunol. Lett., 2009-11-04;127(2):150-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.
Authors: Funderburg NT, Mayne E, Sieg SF
Blood, 2009-10-14;115(2):161-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
J. Immunol., 2009-07-10;183(3):1739-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
Nat. Immunol., 2009-07-05;10(8):857-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
Authors: Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
Eur. J. Immunol., 2009-05-01;39(5):1221-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009-03-09;206(3):535-48.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
Bone, 2009-03-02;44(6):1143-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
Circulation, 2009-03-02;119(10):1424-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts.
Authors: Mizutani K, Sud S, Pienta KJ
J. Cell. Biochem., 2009-03-01;106(4):563-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
Authors: Yammani RR, Long D, Loeser RF
Arthritis Rheum., 2009-03-01;60(3):792-800.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits.
Authors: Niu KC, Huang WT, Lin MT, Huang KF
Eur. J. Pharmacol., 2009-01-21;606(1):240-5.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.
Authors: Ara T, Song L, Shimada H, Keshelava N, Russell HV, Metelitsa LS, Groshen SG, Seeger RC, DeClerck YA
Cancer Res., 2009-01-01;69(1):329-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
Authors: Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J
Arthritis Rheum., 2008-12-01;58(12):3820-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.
Authors: Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE
Proc. Natl. Acad. Sci. U.S.A., 2008-09-16;105(38):14692-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation.
Authors: Kolliputi N, Waxman AB
Am. J. Respir. Cell Mol. Biol., 2008-09-05;40(3):314-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.
Authors: Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P
J. Immunol., 2008-08-15;181(4):2772-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma.
Authors: Osei-Kumah A, Smith R, Clifton VL
Cytokine, 2008-07-17;43(2):187-93.
Applications: ELISA (Standard)

IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells.
Authors: Gerber SA, Pober JS
J. Immunol., 2008-07-15;181(2):1052-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation.
Authors: Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R
J. Immunol., 2008-05-15;180(10):6629-39.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment.
Authors: Chong DY, Boehlke CS, Zheng QD, Zhang L, Han Y, Zacks DN
Invest. Ophthalmol. Vis. Sci., 2008-03-31;49(7):3193-200.
Species: Mouse, Rat
Sample Types: In Vivo
Applications: In Vivo

Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions.
Authors: Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, Piacibello W, Aglietta M, Fagioli F
Exp. Hematol., 2008-02-01;36(2):235-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.
Authors: Yang HT, Cohen P, Rousseau S
Cell. Signal., 2007-11-07;20(2):375-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling.
Authors: Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F
Stem Cells, 2007-10-25;26(1):279-89.
Applications: ELISA (Standard)

Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model.
Authors: Neri P, Kumar S, Fulciniti MT, Vallet S, Chhetri S, Mukherjee S, Tai Y, Chauhan D, Tassone P, Venuta S, Munshi NC, Hideshima T, Anderson KC, Raje N
Clin. Cancer Res., 2007-10-01;13(19):5903-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ultrasensitive flow-based immunoassays using single-molecule counting.
Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
Clin. Chem., 2007-09-21;53(11):1990-5.
Applications: ELISA (Standard)

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
J. Biol. Chem., 2007-08-24;282(43):31643-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Authors: Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW
Transplantation, 2007-07-27;84(2):196-206.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates.
Authors: Luty WH, Rodeberg D, Parness J, Vyas YM
J. Immunol., 2007-07-15;179(2):819-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork.
Authors: Kelley MJ, Rose AY, Song K, Chen Y, Bradley JM, Rookhuizen D, Acott TS
Invest. Ophthalmol. Vis. Sci., 2007-06-01;48(6):2634-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
J. Immunol., 2007-05-01;178(9):5973-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Beta-2-microglobulin is an androgen-regulated secreted protein elevated in serum of patients with advanced prostate cancer.
Authors: Gross M, Top I, Laux I, Katz J, Curran J, Tindell C, Agus D
Clin. Cancer Res., 2007-04-01;13(7):1979-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression.
Authors: Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H
Int. J. Oncol., 2007-04-01;30(4):977-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
Authors: van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH
Dig. Dis. Sci., 2007-03-30;52(10):2775-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells.
Authors: Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE
J. Immunol., 2007-03-01;178(5):2872-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
Authors: Brechter AB, Lerner UH
Arthritis Rheum., 2007-03-01;56(3):910-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
Authors: Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
Stem Cells, 2007-02-01;25(2):490-9.
Species: Human, Mouse, Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators.
Authors: Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C, Zakynthinos S, Armaganidis A, Papapetropoulos A, Roussos C
Crit. Care Med., 2007-01-01;35(1):199-206.
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay

Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
Authors: Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
J. Immunol., 2006-12-01;177(11):7665-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
J. Exp. Med., 2006-11-20;203(12):2763-77.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
J. Endocrinol., 2006-10-01;191(1):65-81.
Species: Hamster
Sample Types: Whole Cells
Applications: Bioassay

Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle.
Authors: Ammit AJ, Moir LM, Oliver BG, Hughes JM, Alkhouri H, Ge Q, Burgess JK, Black JL, Roth M
Am. J. Physiol. Lung Cell Mol. Physiol., 2006-08-25;292(1):L199-206.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells.
Authors: Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S
Cell Death Differ., 2006-02-03;13(10):1686-96.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Th2 cytokine response in Major Depressive Disorder patients before treatment.
Authors: Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G
J. Neuroimmunol., 2006-02-02;172(1):156-65.
Applications: ELISA (Standard)

Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes.
Authors: Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC
J. Immunol. Methods, 2005-11-21;308(1):138-55.
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Bioassay

A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
Authors: von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A
Blood, 2005-10-06;107(5):1955-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.
Authors: Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ
Proc. Natl. Acad. Sci. U.S.A., 2005-09-26;102(40):14380-5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Growth hormone-induced stimulation of multilineage human hematopoiesis.
Authors: Hanley MB, Napolitano LA, McCune JM
Stem Cells, 2005-06-13;23(8):1170-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery.
Authors: Holst RM, Mattsby-Baltzer I, Wennerholm UB, Hagberg H, Jacobsson B
Acta Obstet Gynecol Scand, 2005-06-01;84(6):551-7.
Applications: ELISA (Standard)

Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2005-04-01;203(1):35-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K.
Authors: Mandelin J, Li TF, Hukkanen M, Liljestrom M, Salo J, Santavirta S, Konttinen YT
J. Rheumatol., 2005-04-01;32(4):713-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

trans fatty acids and systemic inflammation in heart failure.
Authors: Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5.
Applications: ELISA (Standard)

Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Authors: Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C
Proc. Natl. Acad. Sci. U.S.A., 2004-11-09;101(47):16606-11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
J. Immunol., 2004-09-01;173(5):3482-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-22 increases the innate immunity of tissues.
Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
Immunity, 2004-08-01;21(2):241-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus.
Authors: Larsson M, Babcock E, Grakoui A, Shoukry N, Lauer G, Rice C, Walker C, Bhardwaj N
J. Virol., 2004-06-01;78(12):6151-61.
Species: Primate - Pan troglodytes (Chimpanzee)
Sample Types: Whole Cells
Applications: Bioassay

Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
Authors: Phillips TM
Electrophoresis, 2004-06-01;25(10):1652-9.

CD14 is an acute-phase protein.
Authors: Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C
J. Immunol., 2004-04-01;172(7):4470-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
Authors: Copeland S, Siddiqui J, Remick D
J. Immunol. Methods, 2004-01-01;284(1):99-106.
Applications: ELISA (Standard)

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
Authors: McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
J. Clin. Invest., 2003-08-01;112(4):598-607.
Applications: ELISA (Standard)

Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.
Authors: Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA
J. Immunol., 2002-11-01;169(9):5244-51.
Applications: ELISA (Standard)

Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Authors: Erices A, Conget P, Rojas C, Minguell JJ
Exp. Cell Res., 2002-10-15;280(1):24-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro.
Authors: Cork BA, 146, Tuckerman EM, Li TC, Laird SM
2002-09-01;8(9):841-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prospective isolation of human clonogenic common myeloid progenitors.
Authors: Manz MG, 107325, Miyamoto T, Akashi K, Weissman IL
Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases, 2002-08-22;99(18):11872-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
Authors: Shih CC, Hu MC, Hu J
Blood, 2000-03-15;95(6):1957-66.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model.
Authors: Gomez-Navarro J, ¯&h~²@á, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM
2000-01-01;7(1):43-52.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
Authors: Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM
Cancer Res., 1998-09-01;58(17):4008-14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
Authors: Barcena A, Park SW, Banapour B, Muench MO, Mechetner E
Blood, 1996-09-15;88(6):2013-25.
Species: Human
Sample Types:
Applications: Bioassay