Recombinant Human Tau Ladder, CF

Recombinant Human Tau Ladder, CF Summary

Product Specifications

Product Datasheets

Carrier Free

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

Background: Tau

Tau is a microtubule-associated protein expressed primarily in neurons.  Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.  Abnormal Tau phosphorylation may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.  Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.  There are multiple forms of Tau--this product contains equal amounts of the following isoforms:  Tau 352 (0N3R), Tau 381 (1N3R), Tau 383 (0N4R), Tau 410 (2N3R), Tau 412 (1N4R) and Tau 441 (2N4R).  These recombinant proteins are untagged.

Related Research Areas

• Cancer Biomarkers
• Cell Structure and Signaling Molecules
• Diabetic Peripheral Neuropathy
• Microtubules
• Neurofibrillary Tangle Formation
• Neuronal Lineage Markers
• Neuronal Markers
• Synaptic Proteins