Recombinant Human VEGF 165 Protein
See our new Human Recombinant VEGF 165 (11458-VE) made in human cells.
Recombinant Human VEGF 165 Protein Summary
Product Specifications
Ala27-Arg191
Analysis
39-42 kDa, under non-reducing conditions.
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
293-VE
Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. Alternatively, reconstitute at 100‑500 μg/mL in sterile 4 mM HCl containing 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
293-VE/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with trehalose. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. Alternatively, reconstitute at 100-500 μg/mL in sterile 4 mM HCl. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
Recombinant Human VEGF165(Catalog # 293-VE) stimulates proliferation in HUVEC human umbilical vein endothelial cells. The ED50 is 1-6 ng/mL.
As an alternative, please consider our next generation Recombinant Human VEGF 165 (Catalog # BT-VEGF). It has equivalent bioactivity to Recombinant Human VEGF 165 (Catalog # 293-VE). It combines R&D Systems quality with scalability that allows for a solid supply chain. Both Recombinant Human VEGF 165 proteins are measured in a cell proliferation assay using HUVEChuman umbilical vein endothelial cells.
1 μg/lane of Recombinant Human VEGF165was resolved by SDS-PAGE with silver staining, under reducing (R) and non-reducing (NR) conditions, showing major bands at 20-22 kDa and 39-42 kDa, respectively. Multiple bands in gel are due to glycosylation.
Reconstitution Calculator
Background: VEGF
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult (1-3). It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure (4). Humans express alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) in length (4). VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189 (3, 4). Isoforms other than VEGF121 contain basic heparin-binding regions and are not freely diffusible (4). Human VEGF165 shares 88% aa sequence identity with corresponding regions of mouse and rat, 96% with porcine, 95% with canine, and 93% with feline, equine and bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells (4). Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). VEGF165 binds the semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2 (5). VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells (3, 4). In adults, VEGF functions mainly in wound healing and the female reproductive cycle (3). Pathologically, it is involved in tumor angiogenesis and vascular leakage (6, 7). Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (8). VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, oncostatin M and TNF-alpha (3, 4, 9).
Due to its role in angiogenesis of blood vessels, tumor and stroma cells use VEGF to stimulate formation of blood vessels and the proliferation and survival of endothelial cells. Specific immunotherapies targeting the VEGF signaling pathway include the recombinant antibody against VEGF (Bevacizumab), antibodies targeting the main VEGF receptor (VEGFR2), and small molecule inhibitors against VEGF receptor tyrosine kinases (10). Immune checkpoint inhibitors are an important tool in cancer therapies as tumor cells can hijack immune checkpoint signals to evade detection by immune cells. In addition to stimulating the formation of tumor blood vessels, VEGF has immunosuppressive effects by acting on dendritic cells to block their antigen-presenting and T cell stimulatory functions. Targeting VEGF in combination with other immune checkpoint ligands or receptors may prove more effective in immunotherapy approaches to certain cancer types (11). Because of its role in the formation of blood vessels, VEGF is also an important factor in skeletal development where blood supply and vascularization are crucial. This has made VEGF an important molecule in regenerative studies for bone repair as sustained release of VEGF has been shown to improve the efficiency of bone regeneration (12).
In differentiation protocols for stems cells, VEGF is a commonly added growth factor for the transformation of induced pluripotent stem cells into hematopoietic progenitor cells used to make Natural Killer cells (13, 14). VEGF has also been used to transform intermediate mesoderm into kidney glomerular podocytes or stem cell-derived liver spheres (15, 16). VEGF may also be used in assistance of stem cell transplantations by supporting angiogenesis at sites of stem cell transplants or as a honing tool for adipose-derived mesenchymal stem cells or bone marrow stem cells to migrate to (17, 18).- Leung, D.W. et al. (1989) Science 246:1306.
- Keck, P.J. et al. (1989) Science 246:1309.
- Byrne, A.M. et al. (2005) J. Cell. Mol. Med. 9:777.
- Robinson, C.J. and S.E. Stringer (2001) J. Cell. Sci. 114:853.
- Pan, Q. et al. (2007) J. Biol. Chem. 282:24049.
- Weis, S.M. and D.A. Cheresh (2005) Nature 437:497.
- Thurston, G. (2002) J. Anat. 200:575.
- Carvalho, J.F. et al. (2007) J. Clin. Immunol. 27:246.
- Angelo, L.S. and R. Kurzrock (2007) Clin. Cancer Res. 13:2825.
- Apte, R.S. et al. (2019) Cell 176(6):1248.
- Sangro, B. et al. (2021) Nature 18:525-543.
- Hu, K. & Olsen, B.R. (2016) Bone 91:30-38.
- Zhou, Y. et al. (2022) Cancers 14:2266.
- Li, Y. et al. (2018) Cell Stem Cell 23(2):181-192.
- Musah, S. et al. (2018) Nat. Protoc. 13(7):1662-1685.
- Meseguer-Ripolles, J. et al. (2021) STAR Protoc. 2(2):100502.
- Hutchings, G. et al. (2020) Int. J. Mol. Sci. 21(11):3790.
- Zhang, W. et al. (2014) Euro Cell and Mater. 27:1-12.
Citations for Recombinant Human VEGF 165 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture
Authors: Lekkala, VKR;Shrestha, S;Al Qaryoute, A;Dhinoja, S;Acharya, P;Raheem, A;Jagadeeswaran, P;Lee, MY;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Eurycomanone inhibits osteosarcoma growth and metastasis by suppressing GRP78 expression
Authors: Xu, W;Wang, Z;Liu, T;Ma, X;Jiao, M;Zhao, W;Yu, L;Hua, Y;Cai, Z;Li, J;Zhang, T;
Journal of ethnopharmacology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis
Authors: Bisson, JA;Gordillo, M;Kumar, R;de Silva, N;Yang, E;Banks, KM;Shi, ZD;Lee, K;Yang, D;Chung, WK;Huangfu, D;Evans, T;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An examination of the mechanisms driving the therapeutic effects of an AAV expressing a soluble variant of VEGF receptor-1
Authors: Moon, SY;Kim, HJ;Kim, JK;Kim, J;Choi, JS;Won, SY;Park, K;Lee, SHS;
PloS one
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Capture -
Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms
Authors: Landau, S;Zhao, Y;Hamidzada, H;Kent, GM;Okhovatian, S;Lu, RXZ;Liu, C;Wagner, KT;Cheung, K;Shawky, SA;Vosoughi, D;Beroncal, EL;Fernandes, I;Cummins, CL;Andreazza, AC;Keller, GM;Epelman, S;Radisic, M;
Cell stem cell
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction
Authors: ??, Ö;Wang, X;Reddy, JS;Min, Y;Yilmaz, E;Bhattarai, P;Patel, T;Bergman, J;Quicksall, Z;Heckman, MG;Tutor-New, FQ;Can Demirdogen, B;White, L;Koga, S;Krause, V;Inoue, Y;Kanekiyo, T;Cosacak, MI;Nelson, N;Lee, AJ;Vardarajan, B;Mayeux, R;Kouri, N;Deniz, K;Carnwath, T;Oatman, SR;Lewis-Tuffin, LJ;Nguyen, T;Alzheimers Disease Neuroimaging Initiative, ;Carrasquillo, MM;Graff-Radford, J;Petersen, RC;Jr Jack, CR;Kantarci, K;Murray, ME;Nho, K;Saykin, AJ;Dickson, DW;Kizil, C;Allen, M;Ertekin-Taner, N;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model
Authors: Paul, SK;Oshima, M;Patil, A;Sone, M;Kato, H;Maezawa, Y;Kaneko, H;Fukuyo, M;Rahmutulla, B;Ouchi, Y;Tsujimura, K;Nakanishi, M;Kaneda, A;Iwama, A;Yokote, K;Eto, K;Takayama, N;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development
Authors: Lee, JG;Yon, JM;Kim, G;Lee, SG;Kim, CY;Cheong, SA;Kim, HY;Yu, J;Kim, K;Sung, YH;Yoo, HJ;Woo, DC;Rho, JK;Ha, CH;Pack, CG;Oh, SH;Lim, JS;Han, YM;Hong, EJ;Seong, JK;Lee, HW;Lee, SW;Lee, KU;Kim, CJ;Nam, SY;Cho, YS;Baek, IJ;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Unravelling heterogeneous effects of cancer?associated fibroblasts on poor prognosis markers in breast cancer EM?G3 cell line: In vitro?targeted treatment (anti?IL-6, anti?VEGF-A, anti?MFGE8) based on transcriptomic profiling
Authors: Urban, L;Novák, ;?oma, M;Dvo?ánková, B;Lacina, L;áchová, J;Hradilová, M;Svato?ová, P;Kolá?, M;Strnad, H;B?ezinová, J;Smetana, K;Gál, P;Szabo, P;
Oncology reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiopoietin-2 and the Vascular Endothelial Growth Factor Promote Migration and Invasion in Hepatocellular Carcinoma- and Intrahepatic Cholangiocarcinoma-Derived Spheroids
Authors: Romanzi, A;Milosa, F;Marcelli, G;Critelli, RM;Lasagni, S;Gigante, I;Dituri, F;Schepis, F;Cadamuro, M;Giannelli, G;Fabris, L;Villa, E;
Biomedicines
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis
Authors: Chaube, B;Citrin, KM;Sahraei, M;Singh, AK;de Urturi, DS;Ding, W;Pierce, RW;Raaisa, R;Cardone, R;Kibbey, R;Fernández-Hernando, C;Suárez, Y;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models
Authors: Friese-Hamim, M;Ortiz-Ruiz, MJ;Bogatyrova, O;Keil, M;Rohdich, F;Blume, B;Leuthner, B;Czauderna, F;Hahn, D;Jabs, J;Jaehrling, F;Heinrich, T;Kellner, R;Chan, K;Tong, AHY;Wienke, D;Moffat, J;Blaukat, A;Zenke, FT;
Molecular cancer therapeutics
Species: Transgenic Mouse
Sample Types: In Vivo
Applications: In vivo assay -
Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation
Authors: Kang, DH;Kim, Y;Min, S;Lee, SY;Chung, KY;Baek, IJ;Kwon, K;Jo, H;Kang, SW;
Cell reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD40 Ligand-CD40 Interaction Is an Intermediary between Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy
Authors: Abu El-Asrar, AM;Nawaz, MI;Ahmad, A;Dillemans, L;Siddiquei, M;Allegaert, E;Gikandi, PW;De Hertogh, G;Opdenakker, G;Struyf, S;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Plug-and-play protein biosensors using aptamer-regulated in vitro transcription
Authors: Lee, H;Xie, T;Yu, X;Schaffter, SW;Schulman, R;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Hyperthermia Influences the Secretion Signature of Tumor Cells and Affects Endothelial Cell Sprouting
Authors: Maduabuchi, WO;Tansi, FL;Heller, R;Hilger, I;
Biomedicines
Species: Human
Sample Types: Spheroid
Applications: Bioassay -
Peptide Nanofiber System for Sustained Delivery of Anti-VEGF Proteins to the Eye Vitreous
Authors: S Yaylaci, E Dinç, B Ayd?n, AB Tekinay, MO Guler
Pharmaceutics, 2023-04-18;15(4):.
Species: Rabbit
Sample Types: Complex Sample Type
Applications: ELISA Capture -
Targeting neuronal lysosomal dysfunction caused by beta-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct
Authors: A Gehrlein, V Udayar, N Anastasi, ML Morella, I Ruf, D Brugger, S von der Ma, R Thoma, A Rufer, D Heer, N Pfahler, A Jochner, J Niewoehner, L Wolf, M Fueth, M Ebeling, R Villaseñor, Y Zhu, MC Deen, X Shan, Z Ehsaei, V Taylor, E Sidransky, DJ Vocadlo, PO Freskgård, R Jagasia
Nature Communications, 2023-04-12;14(1):2057.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone
Authors: E Lee, EA Lee, E Kong, H Chon, M Llaiqui-Co, CH Park, BY Park, NR Kang, JS Yoo, HS Lee, HS Kim, SH Park, SW Choi, D Vestweber, JH Lee, P Kim, WS Lee, I Kim
Experimental & Molecular Medicine, 2023-02-24;55(2):470-484.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sesamin Attenuates VEGFA-Induced Angiogenesis via Inhibition of Src and FAK Signaling in Chick Chorioallantoic Membrane Model and Human Endothelial EA.hy926 Cells
Authors: T Keratibumr, W Srisuthtay, O Wanachewin, J Klangjorho, T Phitak, P Pothacharo, TH Shwe, P Kongtawele
Biomedicines, 2023-01-11;11(1):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses
Authors: L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy
Viruses, 2022-12-29;15(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Assessment of mouse VEGF neutralization by ranibizumab and aflibercept
Authors: Y Ichiyama, R Matsumoto, S Obata, O Sawada, Y Saishin, M Kakinoki, T Sawada, M Ohji
PLoS ONE, 2022-12-21;17(12):e0278951.
Species: N/A
Sample Types: Recombinant Protein
Applications: Western Blot -
DCZ19931, a novel multi-targeting kinase inhibitor, inhibits ocular neovascularization
Authors: H Zhang, B Li, J Ding, R Ye, Z Xu, Q Zhang, S Feng, Q Jiang, W Zhu, B Yan
Scientific Reports, 2022-12-13;12(1):21539.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
Authors: JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson
Cell Reports, 2022-12-06;41(10):111775.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
Authors: JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, BR Kilburn, CL Evavold, JC Kagan, NM Goldenberg, TH Flo, BE Steinberg
Elife, 2022-12-05;11(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Angiogenic adipokine C1q-TNF-related protein 9 ameliorates myocardial infarction via histone deacetylase 7-mediated MEF2 activation
Authors: SM Lee, JW Lee, I Kim, DC Woo, CG Pack, YH Sung, IJ Baek, CH Jung, YH Kim, CH Ha
Science Advances, 2022-12-02;8(48):eabq0898.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
Authors: JA Oo, K Pálfi, T Warwick, I Wittig, C Prieto-Gar, V Matkovic, I Tomaškovi?, F Boos, J Izquierdo, T Teichmann, K Petriukov, S Haydar, L Maegdefess, Z Wu, MD Pham, J Krishnan, AH Baker, S Günther, HD Ulrich, I Dikic, MS Leisegang, RP Brandes
Cell Reports, 2022-11-15;41(7):111670.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro
Authors: XY Cui, B Stavik, B Thiede, PM Sandset, SM Kanse
International Journal of Molecular Sciences, 2022-11-08;23(22):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effect of triamcinolone acetonide on retinal inflammation and angiogenesis induced by pericyte depletion in mouse
Authors: T Otsuka, T Masuda, Y Takahashi, A Suzuki, A Uemura, R Arakawa, T Okabe, A Naito
Journal of pharmacological sciences, 2022-10-23;151(1):28-36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes
Authors: H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian
Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibitor of differentiation 1 in U87MG glioblastoma cells promotes HUVEC sprouting through endothelin-1
Authors: SH Choi, MJ Park, H Kim
Oncology Letters, 2022-09-27;24(5):413.
Species: Human, Mouse
Sample Types: Spheroid, Whole Tissue
Applications: Bioassay -
Collagen?binding vascular endothelial growth factor (CBD?VEGF) promotes liver regeneration in murine partial hepatectomy
Authors: S Wei, Z Li, Q Shi, X Luan, X Yuan, Y Li, C Guo, X Wu, C Shi, G Di
Molecular Medicine Reports, 2022-09-07;26(5):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Modeling human multi-lineage heart field development with pluripotent stem cells
Authors: D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller
Cell Stem Cell, 2022-09-01;29(9):1382-1401.e8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity
Authors: R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley
Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Isolinderalactone inhibits glioblastoma cell supernatant-induced angiogenesis
Authors: SY Lee, JH Park, KH Cho, H Kim, HK Shin
Oncology Letters, 2022-08-02;24(4):328.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability
Authors: N Gioelli, LJ Neilson, N Wei, G Villari, W Chen, B Kuhle, M Ehling, F Maione, S Willox, S Brundu, D Avanzato, G Koulouras, M Mazzone, E Giraudo, XL Yang, D Valdembri, S Zanivan, G Serini
Nature Communications, 2022-07-20;13(1):4188.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes
Authors: SL Lu, H Omori, Y Zhou, YS Lin, CC Liu, JJ Wu, T Noda
MBio, 2022-07-05;0(0):e0123322.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting
Authors: Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida
Stem Cell Reports, 2022-06-09;0(0):.
Species: Human
Sample Types: Embryoid Bodies
Applications: Bioassay -
Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model
Authors: Y Cheng, A Medina, Z Yao, M Basu, JP Natekar, J Lang, E Sanchez, MB Nkembo, C Xu, X Qian, PTT Nguyen, Z Wen, H Song, GL Ming, M Kumar, MA Brinton, MMH Li, H Tang
Cell Reports, 2022-05-31;39(9):110885.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor's Presence
Authors: HL Deissler, M Rehak, A Wolf
Biomolecules, 2022-05-23;12(5):.
Species: Bovine
Sample Types: Cell Culture Supernates
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Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model
Authors: Q Lian, K Zhang, Z Zhang, F Duan, L Guo, W Luo, BW Mok, A Thakur, X Ke, P Motallebne, V Nicolaescu, J Chen, CY Ma, X Zhou, S Han, T Han, W Zhang, AY Tan, T Zhang, X Wang, D Xu, J Xiang, A Xu, C Liao, FP Huang, YW Chen, J Na, G Randall, HF Tse, Z Chen, Y Chen, HJ Chen
Nature Communications, 2022-04-19;13(1):2028.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors
Authors: BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller
Cell Reports, 2022-04-05;39(1):110621.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Physical and functional interactome atlas of human receptor tyrosine kinases.
Authors: Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M
EMBO Rep, 2022-04-05;23(6):e54041.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay -
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T�cells
Authors: Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown
Cell Stem Cell, 2022-03-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
Authors: DC Kirman, B Renganatha, WK Chui, MW Chen, NA Kaya, R Ge
Cell Death & Disease, 2022-02-23;13(2):172.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect
Authors: TC Ho, SI Yeh, SL Chen, TW Chu, YP Tsao
BMC ophthalmology, 2022-02-22;22(1):88.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intratesticular xenografting of Klinefelter pre-pubertal testis tissue as potential model to study testicular fibrosis
Authors: M Willems, P Sebetaenha, I Gies, V Vloeberghs, H Tournaye, D Van Saen, E Goossens
Reproductive biomedicine online, 2022-01-31;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Cell Culture -
Long Non-Coding RNA LINC02802 Regulates In Vitro Sprouting Angiogenesis by Sponging microRNA-486-5p
Authors: S Rosano, S Parab, A Noghero, D Corà, F Bussolino
International Journal of Molecular Sciences, 2022-01-31;23(3):.
Species: Human
Sample Types: Spheroids
Applications: Bioassay -
Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation
Authors: A Hunziker, I Glas, MO Pohl, S Stertz
Cell Reports, 2022-01-25;38(4):110306.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis
Authors: A Das, D Ash, AY Fouda, V Sudhahar, YM Kim, Y Hou, FZ Hudson, BK Stansfield, RB Caldwell, M McMenamin, R Littlejohn, H Su, MR Regan, BJ Merrill, LB Poole, JH Kaplan, T Fukai, M Ushio-Fuka
Nature Cell Biology, 2022-01-13;24(1):35-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation
Authors: AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf
Frontiers in Physiology, 2022-01-10;12(0):807747.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization
Authors: JH Wang, CL Tseng, FL Lin, J Chen, EH Hsieh, S Lama, YF Chuang, S Kumar, L Zhu, MB McGuinness, J Hernandez, L Tu, PY Wang, GS Liu
Theranostics, 2022-01-01;12(2):657-674.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro
Authors: B Hwang, Y Gho, H Kim, S Lee, SA Hong, TJ Lee, SC Myung, SJ Yun, YH Choi, WJ Kim, SK Moon
Integrative cancer therapies, 2022-01-01;21(0):1534735422111.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway
Authors: M Ling, L Quan, X Lai, L Lang, F Li, X Yang, Y Fu, S Feng, X Yi, C Zhu, P Gao, X Zhu, L Wang, G Shu, Q Jiang, S Wang
International Journal of Molecular Sciences, 2021-12-12;22(24):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs
Authors: R Belvedere, E Morretta, N Novizio, S Morello, O Bruno, C Brullo, A Petrella
Biomolecules, 2021-11-24;11(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
Authors: P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara
Embo Molecular Medicine, 2021-11-15;0(0):e14511.
Species: Bovine, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
CD146 mediates the anti-apoptotic role of Netrin-1 in endothelial progenitor cells under hypoxic conditions
Authors: RC Jiang, XY Zheng, SL Yang, HJ Shi, JH Xi, YJ Zou, HQ Dou, YJ Wang, Y Qin, XL Zhang, Q Xiao
Molecular Medicine Reports, 2021-11-05;25(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis
Authors: M Moncayo-Do, GA Rico-Llano, DA Garzón-Alv, J Becerra, R Visser, MR Fontanilla
Polymers, 2021-09-20;13(18):.
Species: Rats
Sample Types: In Vivo
Applications: In Vivo -
Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells
Authors: JAF Silva, X Qi, MB Grant, ME Boulton
Scientific Reports, 2021-08-30;11(1):17400.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
Authors: Y Wang, Y Zhu, Y Gu, M Ma, Y Wang, S Qi, Y Zeng, R Zhu, X Wang, P Yu, J Xu, Y Shu, FX Yu
Cell Reports, 2021-08-24;36(8):109596.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model
Authors: H Yasuda, M Tanaka, A Nishinaka, S Nakamura, M Shimazawa, H Hara
International Journal of Molecular Sciences, 2021-08-18;22(16):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
Authors: S Ma, LS Mangala, W Hu, E Bayaktar, A Yokoi, W Hu, S Pradeep, S Lee, PD Piehowski, A Villar-Pra, SY Wu, MH McGuire, OD Lara, C Rodriguez-, CJ LaFargue, NB Jennings, KD Rodland, T Liu, V Kundra, PT Ram, S Ramakrishn, G Lopez-Bere, RL Coleman, AK Sood
Cell Reports, 2021-08-17;36(7):109549.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration
Authors: P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk
Theranostics, 2021-07-25;11(17):8430-8447.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy
Authors: AM Abu El-Asr, MI Nawaz, A Ahmad, MM Siddiquei, E Allegaert, PW Gikandi, G De Hertogh, G Opdenakker
Investigative Ophthalmology & Visual Science, 2021-07-01;62(9):32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin &alpha5
Authors: M Richards, S Pal, E Sjöberg, P Martinsson, L Venkatrama, L Claesson-W
Cell Reports, 2021-06-22;35(12):109268.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro
Authors: H Iseoka, S Miyagawa, Y Sakai, Y Sawa
Stem Cell Research, 2021-06-11;54(0):102420.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF counteracts amyloid-&beta-induced synaptic dysfunction
Authors: L Martin, P Bouvet, N Chounlamou, C Watrin, R Besançon, D Pinatel, D Meyronet, J Honnorat, A Buisson, PA Salin, C Meissirel
Cell Reports, 2021-05-11;35(6):109121.
Species: Human
Sample Types: Cell Culture Supernates, Whole Cells
Applications: Bioassay, ELISA Capture -
The Role of Heparan Sulfate and Neuropilin 2 in VEGFA Signaling in Human Endothelial Tip Cells and Non-Tip Cells during Angiogenesis In Vitro
Authors: MG Dallinga, YI Habani, AWM Schimmel, GM Dallinga-T, CJF van Noorde, I Klaassen, RO Schlingema
Cells, 2021-04-16;10(4):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Vascular Endothelial Growth Factor and Mesenchymal Stem Cells Revealed Similar Bone Formation to Allograft in a Sheep Model
Authors: CH Dreyer, NR Jørgensen, S Overgaard, L Qin, M Ding
BioMed Research International, 2021-03-03;2021(0):6676609.
Species: Sheep
Sample Types: In Vivo
Applications: Bioassay -
Lipid Raft Association Stabilizes VEGF Receptor 2 in Endothelial Cells
Authors: IO Zabroski, MA Nugent
International Journal of Molecular Sciences, 2021-01-14;22(2):.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids
Authors: M Souidi, Y Sleiman, I Acimovic, J Pribyl, A Charrabi, V Baecker, V Scheuerman, M Pesl, S Jelinkova, P Skladal, P Dvorak, A Lacampagne, V Rotrekl, AC Meli
International Journal of Molecular Sciences, 2021-01-11;22(2):.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function
Authors: J Wu, M Kong, Y Lou, L Li, C Yang, H Xu, Y Cui, H Hao, Z Liu
Frontiers in Pharmacology, 2021-01-11;11(0):608518.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay -
Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways
Authors: C Zhong, P Li, S Argade, L Liu, A Chilla', W Liang, H Xin, B Eliceiri, B Choudhury, N Ferrara
Nature Communications, 2020-12-10;11(1):6330.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution
Authors: Z Wang, M Cui, AM Shah, W Tan, N Liu, R Bassel-Dub, EN Olson
Cell Reports, 2020-12-08;33(10):108472.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Amyloid-&beta Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells
Authors: E Ristori, V Cicaloni, L Salvini, L Tinti, C Tinti, M Simons, F Corti, S Donnini, M Ziche
Cells, 2020-11-19;9(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
Authors: F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen
Res Sq, 2020-09-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hydrogel Network Dynamics Regulate Vascular Morphogenesis
Authors: Z Wei, R Schnellman, HC Pruitt, S Gerecht
Cell Stem Cell, 2020-09-14;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF-A splice variants bind VEGFRs with differential affinities
Authors: SB Mamer, A Wittenkell, PI Imoukhuede
Sci Rep, 2020-09-02;10(1):14413.
Species: N/A, Human
Sample Types: Protein, Recombinant Protein
Applications: Bioassay -
Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer
Authors: DH Shin, JY Jo, SH Kim, M Choi, C Han, BK Choi, SS Kim
Cancers (Basel), 2020-08-24;12(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Suprachoroidal gene transfer with nonviral nanoparticles
Authors: J Shen, J Kim, SY Tzeng, K Ding, Z Hafiz, D Long, J Wang, JJ Green, PA Campochiar
Science Advances, 2020-07-03;6(27):.
Species: Rat
Sample Types: Whole Tissue
Applications: Bioassay -
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity
Authors: H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman
Cell Stem Cell, 2020-06-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity
Authors: Z Hu, I Cano, KL Saez-Torre, ME LeBlanc, M Saint-Geni, YS Ng, P Argüeso, PA D'Amore
Cells, 2020-06-05;9(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Group V secreted phospholipase A2 plays a protective role against aortic dissection
Authors: K Watanabe, Y Taketomi, Y Miki, K Kugiyama, M Murakami
J. Biol. Chem., 2020-06-01;295(30):10092-10111.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
PKC?-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization
Authors: R Kumar, AM Mani, NK Singh, GN Rao
Cell Death Dis, 2020-05-07;11(5):325.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kaempferol, a Major Flavonoid in Ginkgo Folium, Potentiates Angiogenic Functions in Cultured Endothelial Cells by Binding to Vascular Endothelial Growth Factor
Authors: WH Hu, HY Wang, YT Xia, DK Dai, QP Xiong, TT Dong, R Duan, GK Chan, QW Qin, KW Tsim
Front Pharmacol, 2020-04-28;11(0):526.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling After Arterial Ischemia
Authors: G Wang, MR de Vries, WMPJ Sol, AM van Oevere, HC de Boer, AJ van Zonnev, PHA Quax, TJ Rabelink, BM van den Be
Cells, 2020-03-29;9(4):.
Species: Human
Sample Types: Whole Cell
Applications: Bioassay -
Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability
Authors: M Díaz-Corán, CM Lin, S Liebner, DA Antonetti
J. Biol. Chem., 2020-02-21;0(0):.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model
Authors: H Iseoka, S Miyagawa, A Saito, A Harada, Y Sawa
Stem Cell Res Ther, 2020-02-18;11(1):69.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice
Authors: F Njau, N Shushakova, H Schenk, VC Wulfmeyer, R Bollin, J Menne, H Haller
PLoS ONE, 2020-01-14;15(1):e0218494.
Species: Human
Sample Types: Whole Cells
-
Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis
Authors: S Matsushima, A Shimizu, M Kondo, H Asano, N Ueno, H Nakayama, N Sato, M Komeno, H Ogita, M Kurokawa-S
Sci Rep, 2020-01-13;10(1):188.
Species: Human
Sample Types: Protein
Applications: Binding Analysis -
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
Cell Stem Cell, 2020;27(1):125-136.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells
Authors: W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho
Stem Cells, 2019-12-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling
Authors: L Wan, Y Zhao, Q Zhang, G Gao, S Zhang, Y Gao, X Chen, X Qian
BMC Complement Altern Med, 2019-12-10;19(1):359.
Species: Chicken, Human
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A
Authors: L Koehler, G Ruiz-Gómez, K Balamuruga, S Rother, J Freyse, S Möller, M Schnabelra, S Köhling, S Djordjevic, D Scharnwebe, J Rademann, MT Pisabarro, V Hintze
Sci Rep, 2019-12-02;9(1):18143.
Species: Human
Sample Types: Protein, Whole Cells
Applications: Bioassay, Surface Plasmon Resonance (SPR -
Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer
Authors: WH Hu, GK Chan, R Duan, HY Wang, XP Kong, TT Dong, KW Tsim
Cancers (Basel), 2019-11-20;11(12):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells
Authors: H Nagano, C Tomida, N Yamagishi, S Teshima-Ko
Int J Mol Sci, 2019-11-09;20(22):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo
Authors: J Li, F Tang, R Li, Z Chen, SM Lee, C Fu, J Zhang, GP Leung
J. Nutr. Biochem., 2019-11-09;77(0):108268.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear
Authors: L Wan, M Lovett, ME Warchol, JS Stone
Hear. Res., 2019-11-08;385(0):107839.
Species: Chicken
Sample Types: Whole Cells
Applications: Organ Culture -
Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion
Authors: M Oh, SB Rho, C Son, K Park, SY Song
Sci Rep, 2019-10-31;9(1):15771.
Species: Human
Sample Types: Whole Cell
Applications: Bioassay -
Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation
Authors: GL Tiemeier, G Wang, SJ Dumas, WMPJ Sol, MC Avramut, T Karakach, VV Orlova, CW van den Be, CL Mummery, P Carmeliet, BM van den Be, TJ Rabelink
Stem Cell Reports, 2019-10-31;13(5):803-816.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway
Authors: P Deshors, C Toulas, F Arnauduc, L Malric, A Siegfried, Y Nicaise, A Lemarié, D Larrieu, M Tosolini, E Cohen-Jona, M Courtade-S, SM Evrard
Cell Death Dis, 2019-10-28;10(11):816.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
Authors: J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen
Nat Commun, 2019-10-24;10(1):4856.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nuclear localization of the tyrosine kinase BMX mediates VEGFR2 expression
Authors: T Liu, Y Li, H Su, H Zhang, D Jones, HJ Zhou, W Ji, W Min
J. Cell. Mol. Med., 2019-10-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Blue-violet light decreases VEGFa production in an in vitro model of AMD
Authors: M Marie, P Gondouin, D Pagan, C Barrau, T Villette, J Sahel, S Picaud
PLoS ONE, 2019-10-23;14(10):e0223839.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay -
Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion
Authors: SP Chaki, R Barhoumi, GM Rivera
Cancer Med, 2019-10-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive Compounds
Authors: AB Cerezo, M Labrador, A Gutiérrez, R Hornedo-Or, AM Troncoso, MC Garcia-Par
Nutrients, 2019-10-11;11(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
6'-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis
Authors: TW Chung, EY Kim, HJ Choi, CW Han, SB Jang, KJ Kim, L Jin, YJ Koh, KT Ha
Exp. Mol. Med., 2019-10-11;51(10):120.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Heparin potentiates Avastin-mediated inhibition of VEGF binding to fibronectin and rescues Avastin activity at acidic pH
Authors: D Tsiros, CE Sheehy, S Pecchia, MA Nugent
J. Biol. Chem., 2019-10-10;0(0):.
Species: Human, Porcine
Sample Types: Recombinant Protein, Whole Cells
Applications: Bioassay -
Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation
Authors: HJ Lim, J Park, JY Um, SS Lee, HJ Kwak
Cells, 2019-09-30;8(10):.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation
Authors: Q Mei, A Bansal, MKG Jayakumar, Z Zhang, J Zhang, H Huang, D Yu, CJA Ramachandr, DJ Hausenloy, TW Soong, Y Zhang
Nat Commun, 2019-09-27;10(1):4416.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in�vitro and in�vivo
Authors: F Li, Z Liu, H Sun, C Li, W Wang, L Ye, C Yan, J Tian, H Wang
Acta Pharm Sin B, 2019-09-18;10(2):289-300.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy
Authors: CD Lowery, W Blosser, M Dowless, M Renschler, LV Perez, J Stephens, B Pytowski, H Wasserstro, LF Stancato, B Falcon
Oncotarget, 2019-09-17;10(53):5523-5533.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial growth factor 165 inhibits pro-fibrotic differentiation of stromal cells via the DLL4/Notch4/smad7 pathway
Authors: H Lv, Z Nan, P Jiang, Z Wang, M Song, H Ding, D Liu, G Zhao, Y Zheng, Y Hu
Cell Death Dis, 2019-09-12;10(9):681.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cardiomyocyte d-dopachrome tautomerase protects against heart failure
Authors: Y Ma, KN Su, D Pfau, VS Rao, X Wu, X Hu, L Leng, X Du, M Piecychna, K Bedi, SG Campbell, A Eichmann, JM Testani, KB Margulies, R Bucala, LH Young
JCI Insight, 2019-09-05;4(17):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis
Authors: B Hwang, SS Shin, JH Song, YH Choi, WJ Kim, SK Moon
J. Nutr. Biochem., 2019-09-01;74(0):108230.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
Authors: K Njah, S Chakrabort, B Qiu, S Arumugam, A Raju, AV Pobbati, M Lakshmanan, V Tergaonkar, G Thibault, X Wang, W Hong
Cell Rep, 2019-07-23;28(4):949-965.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply affects the RTKs-AKT-GSK3?-eNOS signaling pathway and endothelial cells survival
Authors: T Jia, J Ciccione, T Jacquet, M Maurel, T Montheil, A Mehdi, J Martinez, B Eymin, G Subra, JL Coll
Int J Pharm, 2019-07-09;568(0):118507.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase
Authors: H Gao, J Chen, T Chen, Y Wang, Y Song, Y Dong, S Zhao, RF Machado
Sci Rep, 2019-07-09;9(1):9949.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model
Authors: S Pecha, K Yorgan, M Röhl, B Geertz, A Hansen, F Weinberger, S Sehner, H Ehmke, H Reichenspu, T Eschenhage, AP Schwoerer
Sci Rep, 2019-07-08;9(1):9831.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation
Authors: L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn
Mol. Vis., 2019-06-30;25(0):329-344.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients
Authors: M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa
Haematologica, 2019-06-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition.
Authors: Ohta R, Sugimura R, Niwa A, Saito M
J Vis Exp, 2019-06-16;0(148):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation
Authors: GA Weiner, SH Shah, CM Angelopoul, AB Bartakova, RS Pulido, A Murphy, E Nudleman, R Daneman, JL Goldberg
Nat Commun, 2019-06-06;10(1):2477.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay -
Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
Authors: G Genet, K Boyé, T Mathivet, R Ola, F Zhang, A Dubrac, J Li, N Genet, L Henrique G, L Benedetti, S Künzel, L Pibouin-Fr, JL Thomas, A Eichmann
Nat Commun, 2019-05-28;10(1):2350.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Therapeutic effect of Cnidium officinale Makino extract on ovariectomized hind-limb ischemic mice
Authors: H Yang, DH Jung, HW Lee
Integr Med Res, 2019-05-04;8(2):107-115.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability
Authors: S Nakamura, T Noguchi, Y Inoue, S Sakurai, A Nishinaka, Y Hida, T Masuda, Y Nakagami, N Horai, H Tsusaki, H Hara, M Shimazawa
Invest. Ophthalmol. Vis. Sci., 2019-05-01;60(6):1943-1952.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates
Authors: K Matsuura, M Wada, K Sakaguchi, Y Matsuhashi, T Shimizu
Regen Ther, 2019-04-25;12(0):6-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
Cell Rep, 2019-04-09;27(2):599-615.e12.
Species: Human
Sample Types: cell culture
Applications: Differentiation, Differentiation -
In-vitro binding analysis of anti-human vascular endothelial growth factor antibodies bevacizumab and aflibercept with canine, feline, and equine vascular endothelial growth factor
Authors: LM Muellerlei, B Buxbaum, B Nell, DA Fux
Res. Vet. Sci., 2019-03-22;124(0):233-238.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA, Western Blot -
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
JCI Insight, 2019-03-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels
Authors: T Emi, K Michaud, E Orton, G Santilli, C Linh, M O'Connell, F Issa, S Kennedy
Molecules, 2019-03-16;24(6):.
Applications: Bioassay -
Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function
Authors: S Jauhiainen, JP Laakkonen, K Ketola, PI Toivanen, T Nieminen, T Ninchoji, AL Levonen, MU Kaikkonen, S Ylä-Herttu
Front Physiol, 2019-03-12;10(0):224.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effect of recombinant human vascular endothelial growth factor on testis tissue xenotransplants from prepubertal boys: a three-case study
Authors: E Ntemou, P Kadam, S Van Laere, D Van Saen, E Vicini, E Goossens
Reprod. Biomed. Online, 2019-03-12;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
The addition of a polyglutamate domain to the angiogenic QK peptide improves peptide coupling to bone graft materials leading to enhanced endothelial cell activation
Authors: NW Pensa, AS Curry, MS Reddy, SL Bellis
PLoS ONE, 2019-03-11;14(3):e0213592.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
Authors: H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta
Cell Stem Cell, 2019-03-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
Authors: T Colunga, M Hayworth, S Kre beta, DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton
Cell Rep, 2019-03-05;26(10):2566-2579.e10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology
Authors: S Aghaabdoll, R Ahangari C, D Norouzian, F Davami, MR Asadi Kara, F Torkashvan, G Vaseghi, R Moazzami, S Latif Diza
Sci Rep, 2019-02-27;9(1):2978.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
Authors: N Muraoka, K Nara, F Tamura, H Kojima, H Yamakawa, T Sadahiro, K Miyamoto, M Isomi, S Haginiwa, H Tani, S Kurotsu, R Osakabe, S Torii, S Shimizu, H Okano, Y Sugimoto, K Fukuda, M Ieda
Nat Commun, 2019-02-20;10(1):674.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application
Authors: E Ito, S Miyagawa, M Takeda, A Kawamura, A Harada, H Iseoka, S Yajima, N Sougawa, N Mochizuki-, S Yasuda, Y Sato, Y Sawa
Sci Rep, 2019-02-13;9(1):1881.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2 and TAB1-TAB3 dependent pathway in endothelial cells
Authors: NJ Grimsey, Y Lin, R Narala, CC Rada, H Mejia-Pena, J Trejo
J. Biol. Chem., 2019-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma
Authors: O Lyros, AK Lamprecht, L Nie, R Thieme, K Götzel, M Gasparri, G Haasler, P Rafiee, R Shaker, I Gockel
Am J Cancer Res, 2019-02-01;9(2):330-346.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS
Authors: T Karnezis, R Farnsworth, NC Harris, SP Williams, C Caesar, DJ Byrne, P Herle, ML Macheda, R Shayan, YF Zhang, S Yazar, SJ Takouridis, C Gerard, S Fox, MG Achen, SA Stacker
Cancer Res., 2019-02-01;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells
Authors: C Abou Fayca, S Gazzeri, B Eymin
Sci Rep, 2019-01-23;9(1):336.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rapid Production of Human VEGF-A following Intradermal Injection of Modified VEGF-A mRNA Demonstrated by Cutaneous Microdialysis in the Rabbit and Pig In Vivo
Authors: S Pehrsson, M Hölttä, G Linhardt, RF Danielson, L Carlsson
Biomed Res Int, 2019-01-15;2019(0):3915851.
Species: Transgenic Rabbit
Sample Types: Microdialysates
Applications: Immunoassay Standard -
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells
Authors: S Stephenson, MA Care, I Fan, A Zougman, DR Westhead, GM Doody, RM Tooze
J. Immunol., 2019-01-14;202(4):1287-1300.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering
Authors: Y Jang, J Choi, N Park, J Kang, M Kim, Y Kim, JH Ju
Exp. Mol. Med., 2019-01-07;51(1):3.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau
Authors: MB Huynh, MO Ouidja, S Chantepie, G Carpentier, A Maïza, G Zhang, J Vilares, R Raisman-Vo, D Papy-Garci
PLoS ONE, 2019-01-04;14(1):e0209573.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Development -
Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells
Authors: T Ikuno, S Ito, T Inoue
J Toxicol Sci, 2019-01-01;44(11):789-797.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Exosomes Derived from Human Induced Pluripotent Stem Cells-Endothelia Cells Promotes Postnatal Angiogenesis in Mice Bearing Ischemic Limbs
Authors: M Ye, Q Ni, H Qi, X Qian, J Chen, X Guo, M Li, Y Zhao, G Xue, H Deng, L Zhang
Int. J. Biol. Sci., 2019-01-01;15(1):158-168.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of concentrated growth factor on proliferation, migration, and differentiation of human dental pulp stem cells in vitro
Authors: R Jin, G Song, J Chai, X Gou, G Yuan, Z Chen
J Tissue Eng, 2018-12-21;9(0):2041731418817.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability
Authors: GA Rodrigues, M Mason, LA Christie, C Hansen, LM Hernandez, J Burke, KA Luhrs, TC Hohman
Invest. Ophthalmol. Vis. Sci., 2018-12-03;59(15):5836-5846.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes
Authors: RD Makin, I Apicella, Y Nagasaka, H Kaneko, SD Turner, N Kerur, J Ambati, BD Gelfand
Invest. Ophthalmol. Vis. Sci., 2018-12-03;59(15):5795-5802.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing
Authors: N Sun, B Ning, KM Hansson, AC Bruce, SA Seaman, C Zhang, M Rikard, CA DeRosa, CL Fraser, M Wågberg, R Fritsche-D, J Wikström, KR Chien, A Lundahl, M Hölttä, LG Carlsson, SM Peirce, S Hu
Sci Rep, 2018-11-30;8(1):17509.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
Authors: A Minagawa, T Yoshikawa, M Yasukawa, A Hotta, M Kunitomo, S Iriguchi, M Takiguchi, Y Kassai, E Imai, Y Yasui, Y Kawai, R Zhang, Y Uemura, H Miyoshi, M Nakanishi, A Watanabe, A Hayashi, K Kawana, T Fujii, T Nakatsura, S Kaneko
Cell Stem Cell, 2018-11-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Preclinical Evaluation of ADVM-022, a Novel Gene Therapy Approach to Treating Wet Age-Related Macular Degeneration
Authors: R Grishanin, B Vuillemeno, P Sharma, A Keravala, J Greengard, C Gelfman, M Blumenkran, M Lawrence, W Hu, S Kiss, M Gasmi
Mol. Ther., 2018-11-13;0(0):.
Species: Primate - Chlorocebus sabaeus (Green Monkey)
Sample Types: Vitreous Humor
Applications: ELISA (Capture) -
Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner
Authors: BJ Hamilton, D Tse, RV Stan
J. Cell. Mol. Med., 2018-11-05;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay -
Bevacizumab or fibronectin gene editing inhibits the osteoclastogenic effects of fibroblasts derived from human radicular cysts
Authors: HC Wang, P Wang, YW Chen, Y Zhang
Acta Pharmacol. Sin., 2018-10-31;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dual-functional gelatin-capped silver nanoparticles for antibacterial and antiangiogenic treatment of bacterial keratitis
Authors: LJ Luo, TY Lin, CH Yao, PY Kuo, M Matsusaki, SG Harroun, CC Huang, JY Lai
J Colloid Interface Sci, 2018-10-17;536(0):112-126.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a ?1 integrin/VEGFR autocrine loop
Authors: A Boudria, C Abou Fayca, T Jia, S Gout, M Keramidas, C Didier, N Lemaître, S Manet, JL Coll, AC Toffart, D Moro-Sibil, C Albiges-Ri, V Josserand, E Faurobert, C Brambilla, E Brambilla, S Gazzeri, B Eymin
Oncogene, 2018-09-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer
Authors: LS Pane, FG Fulcoli, A Cirino, A Altomonte, R Ferrentino, M Bilio, A Baldini
Dis Model Mech, 2018-08-30;11(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sensory neuronal sensitisation occurs through HMGB-1/ RAGE and TRPV1 in high glucose conditions
Authors: SM Bestall, RP Hulse, Z Blackley, M Swift, N Ved, K Paton, N Beazley-Lo, DO Bates, LF Donaldson
J. Cell. Sci., 2018-07-26;0(0):.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture
Authors: S Masuda, K Matsuura, T Shimizu
Regen Ther, 2018-07-07;9(0):1-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
Authors: K Koefoed, J Skat-Rørda, P Andersen, CB Warzecha, M Pye, TA Andersen, KD Ajbro, E Bendsen, M Narimatsu, F Vilhardt, LB Pedersen, JL Wrana, RH Anderson, K Møllgård, ST Christense, LA Larsen
Sci Rep, 2018-06-22;8(1):9542.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor Vezf1 represses the expression of the antiangiogenic factor d2 in endothelial cells
Authors: L Alabdi, M He, Q Yang, AB Norvil, H Gowher
J. Biol. Chem., 2018-05-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response
Authors: N Ueda, Y Uemura, R Zhang, S Kitayama, S Iriguchi, Y Kawai, Y Yasui, M Tatsumi, T Ueda, TY Liu, Y Mizoro, C Okada, A Watanabe, M Nakanishi, S Senju, Y Nishimura, K Kuzushima, H Kiyoi, T Naoe, S Kaneko
Stem Cell Reports, 2018-05-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis
Authors: X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang
Cell Stem Cell, 2018-05-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab
Authors: N Seo, A Polozova, M Zhang, Z Yates, S Cao, H Li, S Kuhns, G Maher, HJ McBride, J Liu
MAbs, 2018-04-20;0(0):1-58.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Capture -
EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF
Authors: E Groppa, S Brkic, A Uccelli, G Wirth, P Korpisalo-, M Filippova, B Dasen, V Sacchi, MG Muraro, M Trani, S Reginato, R Gianni-Bar, S Ylä-Herttu, A Banfi
EMBO Rep., 2018-04-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
MicroRNA-134 inhibits osteosarcoma angiogenesis and proliferation by targeting the VEGFA/VEGFR1 pathway
Authors: L Zhang, Z Lv, J Xu, C Chen, Q Ge, P Li, D Wei, Z Wu, X Sun
FEBS J., 2018-03-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis
Authors: YC Lin, CY Liu, R Kannagi, RB Yang
Arterioscler. Thromb. Vasc. Biol., 2018-03-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs
Authors: M Chen, T Qiu, J Wu, Y Yang, GD Wright, M Wu, R Ge
Cell Death Differ., 2018-03-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Telatinib is an effective targeted therapy for pseudomyogenic hemangioendothelioma
Authors: DGP van IJzend, S Sleijfer, H Gelderblom, FALM Eskens, GJ van Leende, K Szuhai, JVMG Bovee
Clin. Cancer Res., 2018-03-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A safety and immunogenicity study of immunization with hVEGF26-104/RFASE in cynomolgus monkeys
Authors: MQ Wentink, HMW Verheul, AW Griffioen, KA Schafer, S McPherson, RJ Early, HJ van der Vl, TD de Gruijl
Vaccine, 2018-03-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response
Authors: L Corsuto, S Rother, L Koehler, E Bedini, S Moeller, M Schnabelra, V Hintze, C Schiraldi, D Scharnwebe
Carbohydr Polym, 2018-03-01;191(0):53-64.
Species: Human
Sample Types: Carbohydrates
Applications: Bioassay -
IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma
Authors: S Conroy, FAE Kruyt, M Wagemakers, KPL Bhat, WFA den Dunnen
Oncotarget, 2018-02-28;9(21):15721-15731.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes
Authors: KB Neves, FJ Rios, L van der Me, R Alves-Lope, AC Cameron, M Volpe, AC Montezano, C Savoia, RM Touyz
Hypertension, 2018-02-26;71(4):638-647.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain
Authors: JM Dave, T Mirabella, SD Weatherbee, DM Greif
Dev. Cell, 2018-02-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression
Authors: Z Pan, J Zhuang, C Ji, Z Cai, W Liao, Z Huang
Oncol Lett, 2018-02-07;15(4):4821-4826.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Establishment of a three-dimensional model to study human uterine angiogenesis
Authors: CL Duran, CA Abbey, KJ Bayless
Mol. Hum. Reprod., 2018-02-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development
Authors: J Richter, EG Stanley, ES Ng, AG Elefanty, D Traver, K Willert
Genes (Basel), 2018-01-29;9(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer
Authors: S Gogalic, U Sauer, S Doppler, C Preininger
Biosensors (Basel), 2018-01-24;8(1):.
Species: Human
Sample Types: Urine
-
?-Escin Effectively Modulates HUVECS Proliferation and Tube Formation
Authors: L Varinská, L Fáber, M Kello, E Petrovová, ? Balážová, P Solár, M ?oma, P Urdzík, J Mojžiš, E Švajdlenka, P Mu?aji, P Gál
Molecules, 2018-01-17;23(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies
Authors: R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson
Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):.
Applications: Bioassay -
VEGF may contribute to macrophage recruitment and M2 polarization in the decidua
Authors: KC Wheeler, MK Jena, BS Pradhan, N Nayak, S Das, CD Hsu, DS Wheeler, K Chen, NR Nayak
PLoS ONE, 2018-01-11;13(1):e0191040.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endoglin interacts with VEGFR2 to promote angiogenesis
Authors: H Tian, JJ Huang, C Golzio, X Gao, M Hector-Gre, N Katsanis, GC Blobe
FASEB J., 2018-01-11;0(0):fj201700867RR.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis
Authors: H Alsaffar, N Martino, JP Garrett, AP Adam
Am. J. Physiol., Cell Physiol., 2018-01-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis
Authors: J Cao, M Ehling, S März, J Seebach, K Tarbashevi, T Sixta, ME Pitulescu, AC Werner, B Flach, E Montanez, E Raz, RH Adams, H Schnittler
Nat Commun, 2017-12-20;8(1):2210.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells
Authors: DJ LaValley, MR Zanotelli, F Bordeleau, W Wang, SC Schwager, CA Reinhart-K
Converg Sci Phys Oncol, 2017-11-29;3(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics
Authors: SB Mamer, S Chen, JC Weddell, A Palasz, A Wittenkell, M Kumar, PI Imoukhuede
Sci Rep, 2017-11-27;7(1):16439.
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance -
Antiangiogenic effect of dasatinib in murine models of oxygen-induced retinopathy and laser-induced choroidal neovascularization
Authors: S Seo, W Suh
Mol. Vis., 2017-11-24;23(0):823-831.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis
Authors: M Nagao, JL Hamilton, R Kc, AD Berendsen, X Duan, CW Cheong, X Li, HJ Im, BR Olsen
Sci Rep, 2017-10-12;7(1):13027.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2
Authors: GA Howe, K Kazda, CL Addison
PLoS ONE, 2017-10-04;12(10):e0185619.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TSLP promotes angiogenesis of human umbilical vein endothelial cells by strengthening the crosstalk between cervical cancer cells and eosinophils
Authors: B Zhang, CY Wei, KK Chang, JJ Yu, WJ Zhou, HL Yang, J Shao, JJ Yu, MQ Li, F Xie
Oncol Lett, 2017-10-03;14(6):7483-7488.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis
Authors: Z Liu, S Yan, J Wang, Y Xu, Y Wang, S Zhang, X Xu, Q Yang, X Zeng, Y Zhou, X Gu, S Lu, Z Fu, DJ Fulton, NL Weintraub, RB Caldwell, W Zhang, C Wu, XL Liu, JF Chen, A Ahmad, I Kaddour-Dj, M Al-Shabraw, Q Li, X Jiang, Y Sun, A Sodhi, L Smith, M Hong, Y Huo
Nat Commun, 2017-09-19;8(1):584.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis
Authors: LA Murray, DM Habiel, M Hohmann, A Camelo, H Shang, Y Zhou, AL Coelho, X Peng, M Gulati, B Crestani, MA Sleeman, T Mustelin, MW Moore, C Ryu, AD Osafo-Addo, JA Elias, CG Lee, B Hu, JD Herazo-May, DA Knight, CM Hogaboam, EL Herzog
JCI Insight, 2017-08-17;2(16):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis
Authors: BK Hong, S You, SA Yoo, D Park, D Hwang, CS Cho, WU Kim
Exp. Mol. Med., 2017-08-04;49(8):e363.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
Authors: JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
Cell Stem Cell, 2017-08-03;21(2):179-194.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Single Routes of Intracellular Signaling is Not Sufficient to Neutralize the Biphasic Disturbance of a Retinal Endothelial Cell Barrier Induced by VEGF-A165
Authors: HL Deissler, GK Lang, GE Lang
Cell. Physiol. Biochem., 2017-07-18;42(4):1493-1513.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
A randomized, single-blind, Phase I trial (INVICTAN-1) assessing the bioequivalence and safety of BI 695502, a bevacizumab biosimilar candidate, in healthy subjects
Authors: W Hettema, C Wynne, B Lang, M Altendorfe, N Czeloth, R Lohmann, S Athalye, D Schliephak
Expert Opin Investig Drugs, 2017-07-12;0(0):.
Applications: ELISA (Capture) -
Apatinib, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Suppresses Pathologic Ocular Neovascularization in Mice
Authors: KL Kim, W Suh
Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3592-3599.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels
Authors: AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema
Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3496-3505.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
PM2.5 exposure decreases viability, migration and angiogenesis in human umbilical vein endothelial cells and human microvascular endothelial cells
Authors: S Chen, X Wu, J Hu, G Dai, A Rong, G Guo
Mol Med Rep, 2017-06-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vertical bone regeneration using rhBMP-2 and VEGF
Authors: L Schorn, C Sproll, M Ommerborn, C Naujoks, NR Kübler, R Depprich
Head Face Med, 2017-06-07;13(1):11.
Species: Porcine
Sample Types: In Vivo
-
Ureteral reconstruction with reinforced collagen scaffolds in a porcine model
Authors: Wout Feitz
J Tissue Eng Regen Med, 2017-06-07;0(0):.
Applications: Bioassay -
Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using (111)In-bevacizumab
Authors: N Patel, S Able, D Allen, E Fokas, B Cornelisse, FV Gleeson, AL Harris, KA Vallis
EJNMMI Res, 2017-05-30;7(1):49.
Applications: Western Blot -
In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor
Authors: P Henno, S Grassin-De, E Belle, M Brollo, E Naline, E Sage, P Devillier, D Israël-Bie
Respir. Res., 2017-05-23;18(1):102.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Ehmt2/G9a controls placental vascular maturation by activating the Notch pathway
Authors: L Chi, A Ahmed, AR Roy, S Vuong, LS Cahill, L Caporiccio, JG Sled, I Caniggia, MD Wilson, P Delgado-Ol
Development, 2017-04-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis
Authors: E Andreuzzi, R Colladel, R Pellicani, G Tarticchio, R Cannizzaro, P Spessotto, B Bussolati, A Brossa, P De Paoli, V Canzonieri, RV Iozzo, A Colombatti, M Mongiat
Matrix Biol., 2017-04-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors
Authors: W Gu, Y Dai, H Qiang, W Shi, C Liao, F Zhao, W Huang, H Qian
Bioorg. Chem., 2017-04-08;72(0):116-122.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gelatin device for the delivery of growth factors involved in endochondral ossification
Authors: LA Ahrens, D Vonwil, J Christense, VP Shastri
PLoS ONE, 2017-04-05;12(4):e0175095.
Species: Chicken
Sample Types: Egg
Applications: Bioassay -
Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina
Authors: N Ved, RP Hulse, SM Bestall, LF Donaldson, JW Bainbridge, DO Bates
Clin. Sci, 2017-03-24;0(0):.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Opposite Effects of Mechanical Action of Fluid Flow on Proangiogenic Factor Secretion from Human Adipose-Derived Stem Cells with and without Oxidative Stress
Authors: Beatriz Bravo
J. Cell. Physiol, 2017-03-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy
Authors: ME LeBlanc, W Wang, X Chen, NB Caberoy, F Guo, C Shen, Y Ji, H Tian, H Wang, R Chen, W Li
J. Exp. Med, 2017-03-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells
Authors: E Giacomelli, M Bellin, L Sala, BJ van Meer, LG Tertoolen, VV Orlova, CL Mummery
Development, 2017-03-15;144(6):1008-1017.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism
Authors: M Shimoda, H Yoshida, S Mizuno, T Hirozane, K Horiuchi, Y Yoshino, H Hara, Y Kanai, S Inoue, M Ishijima, Y Okada
Am. J. Pathol, 2017-03-08;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of VEGF-Induced VEGFR-2 Activation and HUVEC Migration by Melatonin and Other Bioactive Indolic Compounds
Authors: AB Cerezo, R Hornedo-Or, MA Álvarez-Fe, AM Troncoso, MC García-Par
Nutrients, 2017-03-08;9(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Efficacy of aflibercept (EYLEA(�)) on inhibition of human VEGF in vitro
Authors: M Schicht, K Hesse, H Schröder, E Naschberge, W Lamprecht, F Garreis, FP Paulsen, L Bräuer
Ann. Anat, 2017-03-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
Sci Rep, 2017-03-02;7(0):43736.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis
Authors: S Kapur, AP Silverman, AZ Ye, N Papo, D Jindal, MS Blumenkran, JR Cochran
Bioeng Transl Med, 2017-02-17;2(1):81-91.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation
Authors: GL Yang, Z Zhao, TT Qin, D Wang, L Chen, R Xiang, Z Xi, R Jiang, ZS Zhang, J Zhang, LY Li
FASEB J, 2017-02-09;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats
Authors: Xiu Li Ju
Yonsei Med. J., 2017-01-01;58(1):206-216.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis
Authors: Y Akatsu, Y Yoshimatsu, T Tomizawa, K Takahashi, A Katsura, K Miyazono, T Watabe
Cancer Sci, 2017-01-01;108(1):151-155.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Quininib Analogue and Cysteinyl Leukotreine Receptor Antagonist inhibits VEGF-Independent Angiogenesis and Exerts an Additive Anti-angiogenic Response with Bevacizumab
Authors: Clare T Butler
J. Biol. Chem, 2016-12-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling
Sci Rep, 2016-12-19;6(0):39190.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium
Authors: T Toimela
Reprod. Toxicol, 2016-11-30;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells.
Authors: Alessio D'alessio, Gabriella Proietti, Gina Lama, Filippo Biamonte, Libero Lauriola, Umberto Moscato, Angelo Vescovi, Annunziato Mangiola, Cristiana Angelucci, Gigliola Sica
Oncotarget, 2016-11-29;0(0):1949-2553.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
Nat Commun, 2016-11-24;7(0):13517.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis
Authors: Charles R Yates
Mol. Pharmacol., 2016-11-09;91(1):1-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer
Oncotarget, 2016-10-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function
Authors: GJ Prud'homme, Y Glinka, Z Lichner, GM Yousef
Oncotarget, 2016-10-18;7(42):68057-68071.
Species: Human
Sample Types: RNA
Applications: Bioassay -
Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach
Authors: Jialing Liu
Front Mol Neurosci, 2016-10-17;9(0):98.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain
Neurobiol Dis, 2016-09-09;96(0):186-200.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Mesenchymal Stem Cells Reshape and Provoke Proliferation of Articular Chondrocytes by Paracrine Secretion
Sci Rep, 2016-09-06;6(0):32705.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay -
Angiogenic Effects of Collagen/Mesoporous Nanoparticle Composite Scaffold Delivering VEGF165
Biomed Res Int, 2016-09-05;2016(0):9676934.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b
Authors: Jia Li
Mol Ther Nucleic Acids, 2016-08-23;5(8):e354.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Tie1 controls angiopoietin function in vascular remodeling and inflammation
J Clin Invest, 2016-08-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Miniaturizing VEGF: Peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic response
Sci Rep, 2016-08-08;6(0):31295.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy
Invest Ophthalmol Vis Sci, 2016-08-01;57(10):4017-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis.
Authors: Kyu-Yeon Han, Jin-Hong Chang, Hyun Lee, Dimitri T Azar
Investigative Ophthalmology & Visual Science, 2016-06-01;0(0):1552-5783.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularization
Sci Rep, 2016-05-23;6(0):26480.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells.
Authors: Tatsuya Miyake, Keiichi Kumasawa, Noriko Sato, Tsuyoshi Takiuchi, Hitomi Nakamura, Tadashi Kimura
Scientific Reports, 2016-04-22;0(0):2045-2322.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
Authors: I Papangeli, J Kim, I Maier, S Park, A Lee, Y Kang, K Tanaka, OF Khan, H Ju, Y Kojima, K Red-Horse, DG Anderson, AF Siekmann, HJ Chun
Nat Commun, 2016-04-12;7(0):11268.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A metabolite of branched chain amino acids drives vascular fatty acid transport and causes glucose intolerance.
Authors: Jang C.
Thesis.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation
Authors: Robert Thomas
Biotechnol. Prog., 2015-11-28;32(1):215-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
Authors: Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito M, Toyoda M, Umezawa A, Hara T
Exp Hematol, 2015-10-23;44(1):68-74.e10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells.
Authors: Ukaji T, Lin Y, Banno K, Okada S, Umezawa K
PLoS ONE, 2015-09-11;10(9):e0137663.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity.
Authors: Teran M, Nugent M
J Biol Chem, 2015-05-15;290(26):16451-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.
Authors: Rama N, Dubrac A, Mathivet T, Ni Charthaigh R, Genet G, Cristofaro B, Pibouin-Fragner L, Ma L, Eichmann A, Chedotal A
Nat Med, 2015-04-20;21(5):483-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The effect of vascular endothelial growth factor on osteoclastogenesis in rheumatoid arthritis.
Authors: Kim H, Kim K, Kim B, Cho M, Lee S
PLoS ONE, 2015-04-20;10(4):e0124909.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P).
Authors: Williams P, Stilhano R, To V, Tran L, Wong K, Silva E
PLoS ONE, 2015-04-15;10(4):e0123437.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
Authors: Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G
Nat Commun, 2015-03-26;6(0):6576.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
JSI-124 suppresses invasion and angiogenesis of glioblastoma cells in vitro.
Authors: Yuan G, Yan S, Xue H, Zhang P, Sun J, Li G
PLoS ONE, 2015-03-19;10(3):e0118894.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model.
Authors: Yao, Xiujuan, Wang, Wei, Li, Yan, Huang, Ping, Zhang, Qian, Wang, Jingjing, Wang, Wen, Lv, Zhe, An, Yunqing, Qin, Jianguo, Corrigan, Chris J, Huang, Kewu, Sun, Yongchan, Ying, Sun
Respir Res, 2015-03-18;16(0):39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcription factor binding dynamics during human ES cell differentiation.
Authors: Tsankov, Alexande, Gu, Hongcang, Akopian, Veronika, Ziller, Michael, Donaghey, Julie, Amit, Ido, Gnirke, Andreas, Meissner, Alexande
Nature, 2015-02-19;518(7539):344-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system.
Authors: Song B, Fan Y, He W, Zhu D, Niu X, Wang D, Ou Z, Luo M, Sun X
Stem Cells Dev, 2015-02-05;24(9):1053-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
R-Ras protein inhibits autophosphorylation of vascular endothelial growth factor receptor 2 in endothelial cells and suppresses receptor activation in tumor vasculature.
Authors: Sawada J, Li F, Komatsu M
J Biol Chem, 2015-02-02;290(13):8133-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth.
Authors: Wang T, Xiao M, Ge Y, Krepler C, Belser E, Lopez-Coral A, Xu X, Zhang G, Azuma R, Liu Q, Liu R, Li L, Amaravadi R, Xu W, Karakousis G, Gangadhar T, Schuchter L, Lieu M, Khare S, Halloran M, Herlyn M, Kaufman R
Clin Cancer Res, 2015-01-23;21(7):1652-64.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.
Authors: Schaker K, Bartsch S, Patry C, Stoll S, Hillebrands J, Wieland T, Kroll J
J Biol Chem, 2015-01-13;290(10):6408-18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels.
Authors: Jacobo S, Kazlauskas A
J Biol Chem, 2015-01-06;290(10):6349-60.
Species: Human, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Bioassay -
Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity.
Authors: Fleetwood F, Klint S, Hanze M, Gunneriusson E, Frejd F, Stahl S, Lofblom J
Sci Rep, 2014-12-17;4(0):7518.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
The proangiogenic effect of iroquois homeobox transcription factor Irx3 in human microvascular endothelial cells.
Authors: Scarlett K, Pattabiraman V, Barnett P, Liu D, Anderson L
J Biol Chem, 2014-12-15;290(10):6303-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature.
Authors: Yegutkin G, Auvinen K, Rantakari P, Hollmen M, Karikoski M, Grenman R, Elima K, Jalkanen S, Salmi M
Eur J Immunol, 2014-12-15;45(2):562-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
Authors: Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M
Stem Cells, 2014-10-01;32(10):2714-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.
Authors: Seano G, Chiaverina G, Gagliardi P, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain R, Serini G, Bussolino F, Primo L
Nat Cell Biol, 2014-09-14;16(10):931-41, 1-8.
Species: Human, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Bioassay, Cell Culture -
An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors.
Authors: Falcon B, Swearingen M, Gough W, Lee L, Foreman R, Uhlik M, Hanson J, Lee J, McClure D, Chintharlapalli S
PLoS ONE, 2014-09-11;9(9):e106901.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells.
Authors: Kwon, Sang-Mo, Lee, Jun-Hee, Lee, Sang-Hun, Jung, Seok-Yun, Kim, Da-Yeon, Kang, Song-Hwa, Yoo, So-Young, Hong, Jong-Kyu, Park, Ji-Hye, Kim, Jung-Hee, Kim, Sung-Woo, Kim, Yeon-Ju, Lee, Sun-Jin, Kim, Hwi-Gon, Asahara, Takayuki
PLoS ONE, 2014-08-28;9(8):e106310.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.
Authors: Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam D, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton C, Slingerland J
Oncogene, 2014-08-25;34(24):3107-19.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.
Authors: Lanahan A, Lech D, Dubrac A, Zhang J, Zhuang Z, Eichmann A, Simons M
Circulation, 2014-06-30;130(11):902-9.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Conformational remodeling of the fibronectin matrix selectively regulates VEGF signaling.
Authors: Ambesi A, McKeown-Longo P
J Cell Sci, 2014-06-30;127(0):3805-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sox7 is regulated by ETV2 during cardiovascular development.
Authors: Behrens, Ann N, Zierold, Claudia, Shi, Xiaozhon, Ren, Yi, Koyano-Nakagawa, Naoko, Garry, Daniel J, Martin, Cindy M
Stem Cells Dev, 2014-06-17;23(17):2004-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The dineolignan from Saururus chinensis, manassantin B, inhibits tumor-induced angiogenesis via downregulation of matrix metalloproteinases 9 in human endothelial cells.
Authors: Liu, Zhaojie, Lu, Hong, Liu, Rong, Chen, Bin, Wang, Shan, Ma, Junchao, Fu, Jianjian
Oncol Rep, 2014-06-11;32(2):659-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery.
Authors: Thompson M, Mei Y, Weisbrod R, Silver M, Shukla P, Bolotina V, Cohen R, Tong X
J Biol Chem, 2014-06-11;289(29):19907-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.
Authors: Orlova, Valeria, van den Hil, Francijn, Petrus-Reurer, Sandra, Drabsch, Yvette, Ten Dijke, Peter, Mummery, Christin
Nat Protoc, 2014-05-29;9(6):1514-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.
Authors: Hendel, Alon, Hsu, Ivy, Granville, David J
Lab Invest, 2014-05-05;94(7):716-25.
Species: Human
Sample Types: Protein
Applications: Bioassay -
Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.
Authors: Shahrabi-Farahani, Shokoufe, Wang, Lili, Zwaans, Bernadet, Santana, Jeans M, Shimizu, Akio, Takashima, Seiji, Kreuter, Michael, Coultas, Leigh, D'Amore, Patricia, Arbeit, Jeffrey, Akslen, Lars A, Bielenberg, Diane R
Lab Invest, 2014-05-05;94(7):752-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye.
Authors: Michael, Iacovos, Westenskow, Peter D, Hacibekiroglu, Sabiha, Greenwald, Alissa C, Ballios, Brian G, Kurihara, Toshihid, Li, Zhijie, Warren, Carmen M, Zhang, Puzheng, Aguilar, Edith, Donaldson, Laura, Marchetti, Valentin, Baba, Takeshi, Hussein, Samer M, Sung, Hoon-Ki, Iruela-Arispe, M Luisa, Rini, James M, van der Kooy, Derek, Friedlander, Martin, Nagy, Andras
EMBO Mol Med, 2014-05-01;6(5):604-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.
Authors: Lakshmikanthan S, Zieba B, Ge Z, Momotani K, Zheng X, Lund H, Artamonov M, Maas J, Szabo A, Zhang D, Auchampach J, Mattson D, Somlyo A, Chrzanowska-Wodnicka M
Arterioscler Thromb Vasc Biol, 2014-05-01;34(7):1486-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Peroxisome proliferator-activated receptor gamma ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway.
Authors: Qin L, Ren Y, Chen A, Guo F, Xu F, Gong C, Cheng P, Du Y, Liao H
Mol Med Rep, 2014-04-29;10(1):276-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development.
Authors: Kondo, Shunya, Bottos, Alessia, Allegood, Jeremy C, Masson, Regis, Maurer, Francisc, Genoud, Christel, Kaeser, Patrick, Huwiler, Andrea, Murakami, Masato, Spiegel, Sarah, Hynes, Nancy E
PLoS ONE, 2014-04-08;9(4):e94114.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
Authors: Miura S, Kondo J, Takimoto A, Sano-Takai H, Guo L, Shukunami C, Tanaka H, Hiraki Y
PLoS ONE, 2014-04-07;9(4):e94239.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling.
Authors: Nakamura I, Zakharia K, Banini B, Mikhail D, Kim T, Yang J, Moser C, Shaleh H, Thornburgh S, Walters I, Roberts L
PLoS ONE, 2014-04-07;9(4):e92273.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling.
Authors: Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, Simons M
Proc Natl Acad Sci U S A, 2014-04-02;111(15):5514-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway.
Authors: Esquibies A, Karihaloo A, Quaggin S, Bazzy-Asaad A, Cantley L
Respir Res, 2014-03-19;15(0):32.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis.
Authors: Wollin L, Maillet I, Quesniaux V, Holweg A, Ryffel B
J Pharmacol Exp Ther, 2014-02-20;349(2):209-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiogenic sprouting is regulated by endothelial cell expression of Slug.
Authors: Welch-Reardon K, Ehsan S, Wang K, Wu N, Newman A, Romero-Lopez M, Fong A, George S, Edwards R, Hughes C
J Cell Sci, 2014-02-19;127(0):2017-28.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment.
Authors: Sharghi-Namini S, Tan E, Ong L, Ge R, Asada H
Sci Rep, 2014-02-07;4(0):4031.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intraocular pharmacokinetics of ranibizumab in vitrectomized versus nonvitrectomized eyes.
Authors: Ahn S, Ahn J, Park S, Kim H, Hwang D, Park J, Park J, Chung J, Park K, Woo S
Invest Ophthalmol Vis Sci, 2014-01-29;55(1):567-73.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
MMP9 processing of HSPB1 regulates tumor progression.
Authors: Choi, Seo-hyun, Lee, Hae-June, Jin, Yeung Ba, Jang, Junho, Kang, Ga-young, Lee, Minyoung, Kim, Chun-Ho, Kim, Joon, Yoon, Sam S, Lee, Yun-sil, Lee, Yoon-Jin
PLoS ONE, 2014-01-20;9(1):e85509.
Applications: Bioassay -
LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease.
Authors: Grafton K, Moir L, Black J, Hansbro N, Hansbro P, Burgess J, Oliver B
PLoS ONE, 2014-01-15;9(1):e85655.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.
Authors: Kim, Young So, Jung, Seung-Hy, Jung, Dong Ho, Choi, So-Jin, Lee, Yu-Ri, Kim, Jin Sook
PLoS ONE, 2014-01-07;9(1):e83901.
Species: Zebrafish
Sample Types: Whole Organism
Applications: In Vivo -
Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
Authors: Smith A, Bowers S, Stratman A, Davis G
PLoS ONE, 2013-12-31;8(12):e85147.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses.
Authors: Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E
J Allergy Clin Immunol, 2013-12-22;133(4):1162-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.
Authors: Adini, Irit, Ghosh, Kaustabh, Adini, Avner, Chi, Zai-Long, Yoshimura, Takeru, Benny, Ofra, Connor, Kip M, Rogers, Michael, Bazinet, Lauren, Birsner, Amy E, Bielenberg, Diane R, D'Amato, Robert J
J Clin Invest, 2013-12-20;124(1):425-36.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Abl family kinases regulate endothelial barrier function in vitro and in mice.
Authors: Chislock, Elizabet, Pendergast, Ann Mari
PLoS ONE, 2013-12-19;8(12):e85231.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents.
Authors: Pandey, Ram Nare, Wang, Tim Sen, Tadjuidje, Emmanuel, McDonald, Matthew, Rettie, Allan E, Hegde, Rashmi S
PLoS ONE, 2013-12-18;8(12):e84582.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
Authors: Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R
Development, 2013-12-18;141(2):448-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Simple patterned nanofiber scaffolds and its enhanced performance in immunoassay.
Authors: Wang, Jing, Kang, Qin-shu, Lv, Xiao-gua, Song, Jia, Zhan, Na, Dong, Wei-guo, Huang, Wei-hua
PLoS ONE, 2013-12-10;8(12):e82888.
Species: Human
Sample Types: N/A
Applications: Immunoassay Development -
Resveratrol attenuates diabetic nephropathy via modulating angiogenesis.
Authors: Wen, Donghai, Huang, Xinzhong, Zhang, Min, Zhang, Liying, Chen, Jing, Gu, Yong, Hao, Chuan-Mi
PLoS ONE, 2013-12-03;8(12):e82336.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
Authors: Orlova, Valeria, Drabsch, Yvette, Freund, Christia, Petrus-Reurer, Sandra, van den Hil, Francijn, Muenthaisong, Suchitra, Dijke, Peter Te, Mummery, Christin
Arterioscler Thromb Vasc Biol, 2013-10-24;34(1):177-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature.
Authors: Aranguren X, Agirre X, Beerens M, Coppiello G, Uriz M, Vandersmissen I, Benkheil M, Panadero J, Aguado N, Pascual-Montano A, Segura V, Prosper F, Luttun A
Blood, 2013-10-09;122(24):3982-92.
Species: Human
Sample Types: In Vivo
Applications: In Vivo -
Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells.
Authors: Yi K, Jung S, Cho G, Seol H, Hong S, Oh M, Kim H
Placenta, 2013-09-25;35(1):64-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.
Authors: Morishima, Tatsuya, Watanabe, Ken-ichi, Niwa, Akira, Hirai, Hideyo, Saida, Satoshi, Tanaka, Takayuki, Kato, Itaru, Umeda, Katsutsu, Hiramatsu, Hidefumi, Saito, Megumu K, Matsubara, Kousaku, Adachi, Souichi, Kobayashi, Masao, Nakahata, Tatsutos, Heike, Toshio
Haematologica, 2013-08-23;99(1):19-27.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Detection of VEGF-A(xxx)b isoforms in human tissues.
Authors: Bates, David O, Mavrou, Athina, Qiu, Yan, Carter, James G, Hamdollah-Zadeh, Maryam, Barratt, Shaney, Gammons, Melissa, Millar, Ann B, Salmon, Andrew H, Oltean, Sebastia, Harper, Steven J
PLoS ONE, 2013-07-31;8(7):e68399.
Applications: Western Blot -
miR-27a regulates endothelial differentiation of breast cancer stem like cells.
Authors: Tang, W, Yu, F, Yao, H, Cui, X, Jiao, Y, Lin, L, Chen, J, Yin, D, Song, E, Liu, Q
Oncogene, 2013-06-10;33(20):2629-38.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis.
Authors: Zhang G, Panigrahy D, Mahakian L, Yang J, Liu J, Stephen Lee K, Wettersten H, Ulu A, Hu X, Tam S, Hwang S, Ingham E, Kieran M, Weiss R, Ferrara K, Hammock B
Proc Natl Acad Sci U S A, 2013-04-03;110(16):6530-5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Detection of rapalog-mediated therapeutic response in renal cancer xenografts using (6)(4)Cu-bevacizumab immunoPET.
Authors: Chang A, Sohn R, Lu Z, Arbeit J, Lapi S
PLoS ONE, 2013-03-14;8(0):U821.
Species: Human
Sample Types: Antibody
Applications: Bioassay -
HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.
Authors: Stoll S, Bartsch S, Kroll J
PLoS ONE, 2013-03-06;8(3):e58311.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Distinct transcriptional profiles of angioblasts derived from human embryonic stem cells.
Authors: Song S, Jung W, Kim K, Hong W, Kim H, Lee K, Lee K, Suh W
Exp Cell Res, 2013-02-28;319(8):1136-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin.
Authors: Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I
PLoS ONE, 2013-02-20;8(2):e56754.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7.
Authors: Su, Yu-Ting, Gao, Chengzhu, Liu, Yu, Guo, Shuang, Wang, Anthony, Wang, Benlian, Erdjument-Bromage, Hediye, Miyagi, Masaru, Tempst, Paul, Kao, Hung-Yin
Mol Cell Biol, 2013-02-11;33(8):1546-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations.
Authors: You C, Sandalcioglu I, Dammann P, Felbor U, Sure U, Zhu Y
J Cell Mol Med, 2013-02-07;17(3):407-18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.
Authors: Segarra, Marta, Ohnuki, Hidetaka, Maric, Dragan, Salvucci, Ombretta, Hou, Xu, Kumar, Anil, Li, Xuri, Tosato, Giovanna
Blood, 2012-09-24;120(19):4104-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity.
Authors: Kumar S, Sharghi-Namini S, Rao N, Ge R
Am J Pathol, 2012-07-13;181(3):1056-68.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A.
Am. J. Pathol., 2012-05-31;181(2):693-705.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization.
Authors: Hisatomi T, Nakao S, Murakami Y, Noda K, Nakazawa T, Notomi S, Connolly E, She H, Almulki L, Ito Y, Vavvas DG, Ishibashi T, Miller JW
Am. J. Pathol., 2012-05-19;181(1):53-61.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.
Blood, 2012-05-08;119(26):6278-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sjogren's syndrome pathological neovascularization is regulated by VEGF-A-stimulated TACE-dependent crosstalk between VEGFR2 and NF-kappaB.
Authors: Sisto M, Lisi S, Lofrumento DD, D'Amore M, Frassanito MA, Ribatti D
Genes Immun., 2012-04-19;13(5):411-20.
Species: Chicken, Human
Sample Types: In Ovo, Whole Cells
Applications: Bioassay -
Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting.
Authors: van Meeteren LA, Thorikay M, Bergqvist S, Pardali E, Stampino CG, Hu-Lowe D, Goumans MJ, ten Dijke P
J. Biol. Chem., 2012-04-05;287(22):18551-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
PLoS Pathog., 2012-01-12;8(1):e1002486.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.
Authors: Niwa A, Heike T, Umeda K
PLoS ONE, 2011-07-27;6(7):e22261.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non-Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy.
Authors: Yang F, Tang X, Riquelme E, Behrens C, Nilsson MB, Giri U, Varella-Garcia M, Byers LA, Lin HY, Wang J, Raso MG, Girard L, Coombes K, Lee JJ, Herbst RS, Minna JD, Heymach JV, Wistuba II
Cancer Res., 2011-07-01;71(16):5512-5521.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endorepellin, the angiostatic module of perlecan, interacts with both the alpha2beta1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
Authors: Goyal A, Pal N, Concannon M, Paul M, Doran M, Poluzzi C, Sekiguchi K, Whitelock JM, Neill T, Iozzo RV
J. Biol. Chem., 2011-05-19;286(29):25947-62.
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay -
Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway.
Authors: Lee HK, Chauhan SK, Kay E
Blood, 2011-04-01;117(21):5762-71.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells.
Authors: Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P
Mol. Cell. Biol., 2011-01-18;31(6):1174-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation.
Authors: Pirotte S, Lamour V, Lambert V, Alvarez Gonzalez ML, Ormenese S, Noel A, Mottet D, Castronovo V, Bellahcene A
Blood, 2010-12-29;117(8):2515-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8.
Authors: Delgado VM, Nugnes LG, Colombo LL, Troncoso MF, Fernandez MM, Malchiodi EL, Frahm I, Croci DO, Compagno D, Rabinovich GA, Wolfenstein-Todel C, Elola MT
FASEB J., 2010-09-27;25(1):242-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis.
Authors: Brunckhorst MK, Wang H, Lu R, Yu Q
Cancer Res., 2010-09-07;70(18):7283-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain.
Authors: Martino MM, Hubbell JA
FASEB J., 2010-07-29;24(12):4711-21.
Species: Human
Sample Types: Recombinant Protein, Whole Cells
Applications: Bioassay, Surface Plasmon Resonance -
Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7.
Authors: Jung DW, Che ZM, Kim J, Kim K, Kim KY, Williams D, Kim J
Int. J. Cancer, 2010-07-15;127(2):332-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
Authors: Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G
Blood, 2010-07-06;116(16):3099-107.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch.
Authors: Ding W, Knox TR, Tschumper RC
Blood, 2010-07-06;116(16):2984-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma.
Authors: Cocco C, Giuliani N, Di Carlo E
Clin. Cancer Res., 2010-06-29;16(16):4188-97.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Macrophage inhibitory cytokine-1 regulates melanoma vascular development.
Authors: Huh SJ, Chung CY, Sharma A
Am. J. Pathol., 2010-04-29;176(6):2948-57.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
Authors: Ball SG, Bayley C, Shuttleworth CA, Kielty CM
Biochem. J., 2010-03-15;427(1):29-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure.
Authors: Westenbrink BD, Ruifrok WP, Voors AA
Cardiovasc. Res., 2010-02-05;87(1):30-9.
Species: Rat
Sample Types: Plasma
Applications: Bioassay -
Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state.
Authors: Lanner F, Lee KL, Sohl M, Holmborn K, Yang H, Wilbertz J, Poellinger L, Rossant J, Farnebo F
Stem Cells, 2010-02-01;28(2):191-200.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vitreous VEGF clearance is increased after vitrectomy.
Authors: Lee SS, Ghosn C, Yu Z, Zacharias LC, Kao H, Lanni C, Abdelfattah N, Kuppermann B, Csaky KG, D'Argenio DZ, Burke JA, Hughes PM, Robinson MR
Invest. Ophthalmol. Vis. Sci., 2009-12-17;51(4):2135-8.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo -
Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.
Authors: Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Rentsenhand B, Makino H, Ranjan P, Minakuchi K, Sone S
J. Immunol., 2009-12-15;183(12):8176-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway.
Authors: Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML
Carcinogenesis, 2009-12-01;30(12):2005-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lymphangiogenesis and angiogenesis: concurrence and/or dependence? Studies in inbred mouse strains.
Authors: Nakao S, Maruyama K, Zandi S, Melhorn MI, Taher M, Noda K, Nusayr E, Doetschman T, Hafezi-Moghadam A
FASEB J., 2009-10-26;24(2):504-13.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.
Authors: Lee HS, Myers A, Kim J
Am. J. Respir. Crit. Care Med., 2009-09-17;180(11):1056-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants.
Authors: Fujinaga H, Baker CD, Ryan SL, Markham NE, Seedorf GJ, Balasubramaniam V, Abman SH
Am. J. Physiol. Lung Cell Mol. Physiol., 2009-09-04;297(6):L1160-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia.
Authors: Martorell L, Gentile M, Rius J, Rodriguez C, Crespo J, Badimon L, Martinez-Gonzalez J
Mol. Cell. Biol., 2009-08-31;29(21):5828-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo.
Authors: Rennel ES, Varey AH, Churchill AJ, Wheatley ER, Stewart L, Mather S, Bates DO, Harper SJ
Br. J. Cancer, 2009-08-25;101(7):1183-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells.
Authors: Jain P, Manuel SL, Khan ZK, Ahuja J, Quann K, Wigdahl B
J. Virol., 2009-08-19;83(21):10908-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
Authors: Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T
J. Biol. Chem., 2009-08-12;284(42):29109-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.
Authors: Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T
J. Clin. Invest., 2009-07-13;119(8):2257-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association.
Authors: Sakai K, Nakamura T, Matsumoto K, Nakamura T
J. Biol. Chem., 2009-06-24;284(33):22491-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Production of scFv antibody fragments from a hybridoma with functional activity against human vascular endothelial growth factor.
Authors: Irani Y, Brereton HM, Tilton RG
Hybridoma (Larchmt), 2009-06-01;28(3):205-9.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Binding Assay -
Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
Authors: Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro.
Authors: Zhang Y, Fisher N, Newey SE
Stem Cells Dev., 2009-03-01;18(2):359-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation.
Authors: Saulle E, Riccioni R, Coppola S, Parolini I, Diverio D, Riti V, Mariani G, Laufer S, Sargiacomo M, Testa U
Br. J. Haematol., 2009-02-24;145(3):399-411.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sensitive and multiplexed detection of proteomic antigens via quantum dot aggregation.
Authors: Soman C, Giorgio T
Nanomedicine, 2009-02-13;5(4):402-9.
Applications: Quantum Dot -
Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells.
Authors: Hao Q, Wang L, Tang H
Am. J. Physiol., Cell Physiol., 2009-01-28;296(4):C821-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis.
Authors: Gooz P, Gooz M, Baldys A, Hoffman S
Biochem. Biophys. Res. Commun., 2009-01-14;380(1):33-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis.
Authors: Chen H, Campbell RA, Chang Y, Li M, Wang CS, Li J, Sanchez E, Share M, Steinberg J, Berenson A, Shalitin D, Zeng Z, Gui D, Perez-Pinera P, Berenson RJ, Said J, Bonavida B, Deuel TF, Berenson JR
Blood, 2008-12-05;113(9):1992-2002.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis.
Authors: Hao Q, Wang L, Zhao ZJ, Tang H
J. Biol. Chem., 2008-11-09;284(2):799-806.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.
Authors: Ponticelli S, Marasco D, Tarallo V, Albuquerque RJ, Mitola S, Takeda A, Stassen JM, Presta M, Ambati J, Ruvo M, De Falco S
J. Biol. Chem., 2008-10-15;283(49):34250-9.
Species: Human
Sample Types: N/A, Whole Cells
Applications: Bioassay, ELISA (Standard) -
Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.
Authors: Lejmi E, Leconte L, Pedron-Mazoyer S, Ropert S, Raoul W, Lavalette S, Bouras I, Feron JG, Maitre-Boube M, Assayag F, Feumi C, Alemany M, Jie TX, Merkulova T, Poupon MF, Ruchoux MM, Tobelem G, Sennlaub F, Plouet J
Proc. Natl. Acad. Sci. U.S.A., 2008-08-21;105(34):12491-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.
Authors: Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD
J. Am. Coll. Cardiol., 2008-07-29;52(5):387-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis.
Authors: Shin JW, Huggenberger R, Detmar M
Blood, 2008-07-09;112(6):2318-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
Authors: Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ
Cancer Res., 2008-06-15;68(12):4774-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice.
Authors: Zacchigna S, Pattarini L, Zentilin L, Moimas S, Carrer A, Sinigaglia M, Arsic N, Tafuro S, Sinagra G, Giacca M
J. Clin. Invest., 2008-06-01;118(6):2062-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development of anti-atherosclerotic tissue-engineered blood vessel by A20-regulated endothelial progenitor cells seeding decellularized vascular matrix.
Authors: Zhu C, Ying D, Mi J, Li L, Zeng W, Hou C, Sun J, Yuan W, Wen C, Zhang W
Biomaterials, 2008-06-01;29(17):2628-36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression.
Authors: Wanami LS, Chen HY, Peiro S, Garcia de Herreros A, Bachelder RE
Exp. Cell Res., 2008-05-17;314(13):2448-53.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Authors: Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM
Nature, 2008-04-23;453(7194):524-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development and validation of sandwich ELISA microarrays with minimal assay interference.
Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
J. Proteome Res., 2008-04-19;7(6):2406-14.
Applications: ELISA (Standard) -
Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization.
Authors: Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS, Basu S
J. Clin. Invest., 2008-04-01;118(4):1380-9.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.
Authors: Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY
Nat. Med., 2008-03-16;14(4):448-53.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis.
Authors: Clerin V, Shih HH, Deng N, Hebert G, Resmini C, Shields KM, Feldman JL, Winkler A, Albert L, Maganti V, Wong A, Paulsen JE, Keith JC, Vlasuk GP, Pittman DD
Atherosclerosis, 2008-02-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Authors: Narazaki M, Segarra M, Tosato G
Blood, 2008-02-13;111(8):4126-36.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth.
Authors: Ebos JM, Lee CR, Bogdanovic E, Alami J, Van Slyke P, Francia G, Xu P, Mutsaers AJ, Dumont DJ, Kerbel RS
Cancer Res., 2008-01-15;68(2):521-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Fractalkine, a CX3C chemokine, as a mediator of ocular angiogenesis.
Authors: You JJ, Yang CH, Huang JS, Chen MS, Yang CM
Invest. Ophthalmol. Vis. Sci., 2007-11-01;48(11):5290-8.
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay -
Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation.
Authors: Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WS, Yang CY, Chen CH
Diabetes, 2007-10-24;57(1):158-66.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia.
Authors: Yeh WL, Lin CJ, Fu WM
Mol. Pharmacol., 2007-10-17;73(1):170-7.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Glomerular endothelial glycocalyx constitutes a barrier to protein permeability.
Authors: Singh A, Satchell SC, Neal CR
J. Am. Soc. Nephrol., 2007-10-17;18(11):2885-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1.
Authors: Jaalouk DE, Ozawa MG, Sun J, Lahdenranta J, Schlingemann RO, Pasqualini R, Arap W
Cancer Res., 2007-10-15;67(20):9623-9.
Applications: Bioassay -
Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth.
Authors: Rogers MS, Christensen KA, Birsner AE, Short SM, Wigelsworth DJ, Collier RJ, D'Amato RJ
Cancer Res., 2007-10-15;67(20):9980-5.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain.
Authors: Isakova IA, Baker K, Dutreil M, Dufour J, Gaupp D, Phinney DG
Stem Cells, 2007-10-11;25(12):3261-70.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Ultrasensitive flow-based immunoassays using single-molecule counting.
Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
Clin. Chem., 2007-09-21;53(11):1990-5.
Applications: ELISA (Standard) -
Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1.
Authors: Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach JH, Loges S, Kilic E, Weil J, Lauke H, Tilki D, Singer BB, Ergun S
Blood, 2007-08-30;110(13):4223-33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.
Authors: Lin YL, Liang YC, Chiang BL
J. Leukoc. Biol., 2007-08-30;82(6):1473-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis.
Authors: Tsao PN, Chan FT, Wei SC, Hsieh WS, Chou HC, Su YN, Chen CY, Hsu WM, Hsieh FJ, Hsu SM
Crit. Care Med., 2007-08-01;35(8):1955-60.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.
Authors: Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM
Arthritis Rheum., 2007-07-01;56(7):2432-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.
Authors: Pan Q, Chathery Y, Wu Y, Rathore N, Tong RK, Peale F, Bagri A, Tessier-Lavigne M, Koch AW, Watts RJ
J. Biol. Chem., 2007-06-16;282(33):24049-56.
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance -
Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.
Authors: Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM
J. Am. Coll. Cardiol., 2007-06-04;49(24):2341-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression.
Authors: Yeh WL, Lu DY, Lin CJ, Liou HC, Fu WM
Mol. Pharmacol., 2007-05-18;72(2):440-9.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Authors: Ball SG, Shuttleworth CA, Kielty CM
J. Cell Biol., 2007-04-30;177(3):489-500.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.
Authors: Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U
Stem Cells, 2007-04-19;25(8):1862-71.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells.
Authors: Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E
Stem Cells, 2007-03-22;25(6):1456-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Evaluation of a xenogeneic VEGF vaccine in dogs with soft tissue sarcoma.
Authors: Kamstock D, Elmslie R, Thamm D
Cancer Immunol. Immunother., 2007-02-14;56(8):1299-309.
Species: Canine
Sample Types: In Vivo, Plasma
Applications: ELISA (Capture), In Vivo -
The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques.
Authors: Babinska A, Azari BM, Salifu MO, Liu R, Jiang XC, Sobocka MB, Boo D, Al Khoury G, Deitch JS, Marmur JD, Ehrlich YH, Kornecki E
Thromb. Haemost., 2007-02-01;97(2):272-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
Authors: Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
Stem Cells, 2007-02-01;25(2):490-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers.
Authors: Rusk A, McKeegan E, Haviv F, Majest S, Henkin J, Khanna C
Clin. Cancer Res., 2006-12-15;12(24):7444-55.
Species: Canine, Human
Sample Types: Whole Cells
Applications: Bioassay -
Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.
Authors: Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N
Br. J. Haematol., 2006-12-01;135(5):703-14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization.
Authors: Werdich XQ, Penn JS
Invest. Ophthalmol. Vis. Sci., 2006-11-01;47(11):5047-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1.
Authors: Lake AC, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret GY, Letourneur D
J. Biol. Chem., 2006-10-06;281(49):37844-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells.
Authors: Kim BK, Kim SE, Shim JH, Woo DH, Gil JE, Kim SK, Kim JH
FEBS Lett., 2006-10-02;580(25):5869-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.
Authors: Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL
FASEB J., 2006-10-01;20(12):2058-67.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
Multipotent adult progenitor cells from swine bone marrow.
Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
Stem Cells, 2006-08-24;24(11):2355-66.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay -
Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells.
Authors: Kim KL, Shin IS, Kim JM, Choi JH, Byun J, Jeon ES, Suh W, Kim DK
Cardiovasc. Res., 2006-08-07;72(3):394-402.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles.
Authors: Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH
Am. J. Pathol., 2006-07-01;169(1):200-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo.
Authors: Ren WP, Markel DC, Zhang R, Peng X, Wu B, Monica H, Wooley PH
Biomaterials, 2006-06-30;27(30):5161-9.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells.
Authors: Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR
Biochem. Biophys. Res. Commun., 2006-06-12;346(4):1200-6.
Applications: Western Blot -
Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells.
Authors: Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y
Exp. Hematol., 2006-06-01;34(6):760-9.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
Glia, 2006-06-01;53(8):845-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics.
Authors: Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP
Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2701-8.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4.
Authors: Kiyono M, Shibuya M
Oncogene, 2006-05-29;25(54):7131-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells.
Authors: Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K
Stem Cells, 2006-05-25;24(9):2014-22.
Species: Primate - Callitrix jacchus (Common Marmoset)
Sample Types: Whole Cells
Applications: Bioassay -
Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro.
Authors: Getmanova EV, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, Wang J, Ling V, Sun L
Chem. Biol., 2006-05-01;13(5):549-56.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells.
Authors: Tsigkos S, Zhou Z, Kotanidou A, Fulton D, Zakynthinos S, Roussos C, Papapetropoulos A
J. Cell. Physiol., 2006-05-01;207(2):506-11.
Species: Bovine
Sample Types: Cell Culture Supernates
Applications: Bioassay -
The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term.
Authors: Bates DO, MacMillan PP, Manjaly JG, Qiu Y, Hudson SJ, Bevan HS, Hunter AJ, Soothill PW, Read M, Donaldson LF, Harper SJ
Clin. Sci., 2006-05-01;110(5):575-85.
Applications: Western Blot -
Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration.
Authors: Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, Mandron M, Herault JP, Neufeld G, Savi P, Herbert JM, Bono F
Blood, 2006-04-18;108(4):1243-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Osteoprotegerin (OPG)--a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis?
Authors: Cross SS, Yang Z, Brown NJ, Balasubramanian SP, Evans CA, Woodward JK, Neville-Webbe HL, Lippitt JM, Reed MW, Coleman RE, Holen I
Int. J. Cancer, 2006-04-15;118(8):1901-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
Authors: Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J
J. Clin. Invest., 2006-02-01;116(2):422-9.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles.
Authors: Anghelina M, Krishnan P, Moldovan L, Moldovan NI
Am. J. Pathol., 2006-02-01;168(2):529-41.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A.
Authors: Narazaki M, Tosato G
Blood, 2006-01-19;107(10):3892-901.
Applications: ELISA (Standard) -
Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.
Authors: Carr AN, Howard BW, Yang HT, Eby-Wilkens E, Loos P, Varbanov A, Qu A, DeMuth JP, Davis MG, Proia A, Terjung RL, Peters KG
Cardiovasc. Res., 2006-01-10;69(4):925-35.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
Bone, 2005-12-05;38(4):497-508.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy.
Authors: Bagley RG, Weber W, Rouleau C, Teicher BA
Cancer Res., 2005-11-01;65(21):9741-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
Authors: Curbishley SM, Eksteen B, Gladue RP, Lalor P, Adams DH
Am. J. Pathol., 2005-09-01;167(3):887-99.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis.
Authors: Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP, Baker CH, Gallick GE
Cancer Res., 2005-08-15;65(16):7214-22.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction.
Authors: Voisine P, Bianchi C, Khan TA, Ruel M, Xu SH, Feng J, Li J, Malik T, Rosinberg A, Sellke FW
J. Thorac. Cardiovasc. Surg., 2005-06-01;129(6):1414-20.
Species: Porcine
Sample Types: In Vivo
Applications: In Vivo -
Human peripheral blood eosinophils induce angiogenesis.
Authors: Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F
Int. J. Biochem. Cell Biol., 2005-03-01;37(3):628-36.
Species: Chicken, Rat
Sample Types: Whole Cells, Whole Tissue
Applications: Bioassay -
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
Authors: Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
J. Immunol., 2005-01-01;174(1):215-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microvascular patterning is controlled by fine-tuning the Akt signal.
Authors: Sun JF, Phung T, Shiojima I, Felske T, Upalakalin JN, Feng D, Kornaga T, Dor T, Dvorak AM, Walsh K, Benjamin LE
Proc. Natl. Acad. Sci. U.S.A., 2004-12-20;102(1):128-33.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice.
Authors: Eubank TD, Roberts R, Galloway M, Wang Y, Cohn DE, Marsh CB
Immunity, 2004-12-01;21(6):831-42.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Inhibition of tumor growth and angiogenesis by soluble EphB4.
Authors: Martiny-Baron G, Korff T, Schaffner F, Esser N, Eggstein S, Marme D, Augustin HG
Neoplasia, 2004-05-01;6(3):248-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties.
Authors: Satchell SC, Anderson KL, Mathieson PW
J. Am. Soc. Nephrol., 2004-03-01;15(3):566-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.
Authors: Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP
Invest. Ophthalmol. Vis. Sci., 2004-02-01;45(2):368-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
VEGF-promoted surgical angiogenesis in necrotic bone.
Authors: Suzuki O, Bishop AT, Sunagawa T, Katsube K, Friedrich PF
Microsurgery, 2004-01-01;24(1):85-91.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo -
Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1.
Authors: Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY
Eur. J. Clin. Invest., 2003-10-01;33(10):883-90.
Applications: ELISA (Standard) -
Expansion of human SCID-repopulating cells under hypoxic conditions.
Authors: Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC
J. Clin. Invest., 2003-07-01;112(1):126-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells.
Authors: Fuller T, Korff T, Kilian A, Dandekar G, Augustin HG
J. Cell. Sci., 2003-05-06;116(0):2461-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops.
Authors: Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS
Int. J. Cancer, 2003-05-01;104(5):603-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
Authors: Maynard SE, Min JY, Merchan J, Lim KH, Mondal S, Stillman IE, Epstein FH, Karumanchi SA
J. Clin. Invest., 2003-03-01;111(5):649-58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3.
Authors: Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC
Cancer Res., 2003-02-15;63(4):887-92.
Species: Human
Sample Types: Whole Cells
Applications: Binding Assay -
Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein.
Authors: Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R
Int. J. Dev. Biol., 2003-02-01;47(1):15-29.
Species: Xenopus
Sample Types: In Vivo
Applications: In Vivo -
Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome.
Authors: Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM
J. Immunol., 2002-12-01;169(11):6515-21.
Applications: ELISA (Standard) -
VEGF signaling is required for the assembly but not the maintenance of embryonic blood vessels.
Authors: Argraves WS, Larue AC, Fleming PA, Drake CJ
Dev. Dyn., 2002-11-01;225(3):298-304.
Species: Avian - Quail, Mouse
Sample Types: In Vivo, Whole Tissue
Applications: Bioassay, In Vivo -
Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus.
Authors: Lee S, 107340, Zheng M, Kim B, Rouse BT
Identification of NHLRC1 as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS), 2002-10-01;110(8):1105-11.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
A critical role of placental growth factor in the induction of inflammation and edema formation.
Authors: Oura H, Bertoncini J, Velasco P, Brown LF, Carmeliet P, Detmar M
Blood, 2002-09-05;101(2):560-7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
17Beta-estradiol up-regulates vascular endothelial growth factor receptor-2 expression in human myometrial microvascular endothelial cells: role of estrogen receptor-alpha and -beta.
Authors: Gargett CE, Zaitseva M, Bucak K, Chu S, Fuller PJ, Rogers PA
J. Clin. Endocrinol. Metab., 2002-09-01;87(9):4341-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Quantitative assessment of the integrity of the blood-retinal barrier in mice.
Authors: Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA
Invest. Ophthalmol. Vis. Sci., 2002-07-01;43(7):2462-7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin.
Authors: Chen CT, 2018, Lin J, Li Q, Phipps SS, Jakubczak JL, Stewart DA, Skripchenko Y, Forry-Schaudies S, Wood J, Schnell C, Hallenbeck PL
132, 2000-09-20;11(14):1983-96.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo
FAQs
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Is this protein glycosylated?
Recombinant human VEGF165, Catalog # 293-VE or 293-VE/CF, is produced in Sf-21 cells and is glycosylated. This protein shows up as more than one band on SDS-PAGE. Please refer to the SDS-PAGE image located on the product-specific datasheet.
Reviews for Recombinant Human VEGF 165 Protein
Average Rating: 4.8 (Based on 30 Reviews)
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Reason for Rating: Works well for my assay. I used it and ANG1 (ANGPT1) as controls for activation of phospho-VEGFR2 in HUVEC.
Reason for Rating: iPSC differentiation to endothelial cell
Reason for Rating: This is a potent VEGFA and we are using it for a decade
The experiment was aimed to test the effect of human VEGFA in EC migration by scratch wound migration assay.
Reason for Rating: Quick shipping
Nice result
The recombinant human VEGF protein was used as the calibration reagent in MSD assay with biotinylated MAB293 (capture) and Sulfo-Tag labeled AF-293-NA (detection) antibodies.
Reason for Rating: Very good agonist and I always see a very good response with VEGF-A on retinal endothelial migration and it also highly induces various signaling proteins.
I have used at 40 ng/ml concentration in a serum-free media both for cell migration and cell signaling (western blots).
Human Recombinant VEGF165 protein is a cornerstone reagent for our protocol which looks to differentiate induced pluripotent stem cells into endothelial cells (ECs). Activin A and BMP-4 purchased from R&D was also utilized in the initial differentiation stages in combination with VEGF165. We routinely perform this differentiation protocol and VEGF165 has been reliable in expanding iPSC-derived ECs to sufficient quantities required for us to recellularize rat lung scaffolds which have been decellularized.
rhVEGF is used to induce differentiation of iPSC to cardiomyotcyes.
We use VEGF in a variety of iPSC differentiations. The differeniations include; endothelial, hematopoietic, and hepatoctye to name a few. There has been no lot to lot variability, all lots have preformed the same across multiple experiments.