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Recombinant Mouse IFN-beta Protein, CF

Catalog #: 12401-1
21 Citations Datasheet / COA / SDS
Newer Version Available: 8234-MB/CF
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12401-1
R&D Systems Recombinant Proteins and Enzymes
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Citations (21)
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse IFN-beta Protein, CF Summary

Product Specifications

Accession #
K00020

Product Datasheets

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12401-1

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

12401-1

Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Citations for Recombinant Mouse IFN-beta Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

21 Citations: Showing 1 - 10
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  1. Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response
    Authors: A Fedoriw, L Shi, S O'Brien, KN Smitheman, Y Wang, J Hou, C Sherk, S Rajapurkar, J Laraio, LJ Williams, C Xu, G Han, Q Feng, MT Bedford, L Wang, O Barbash, RG Kruger, P Hwu, HP Mohammad, W Peng
    Cancer Immunology Research, 2022-04-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice
    Authors: A Wang, SD Pope, JS Weinstein, S Yu, C Zhang, CJ Booth, R Medzhitov
    Proc. Natl. Acad. Sci. U.S.A., 2019-01-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
    Authors: S Li, Z Hong, Z Wang, F Li, J Mei, L Huang, X Lou, S Zhao, L Song, W Chen, Q Wang, H Liu, Y Cai, H Yu, H Xu, G Zeng, Q Wang, J Zhu, X Liu, N Tan, C Wang
    Cell Rep, 2018-12-18;25(12):3405-3421.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages
    Authors: H Cui, S Banerjee, S Guo, N Xie, G Liu
    J. Immunol., 2018-03-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation
    Authors: JC Santos, MS Dick, B Lagrange, D Degrandi, K Pfeffer, M Yamamoto, E Meunier, P Pelczar, T Henry, P Broz
    EMBO J., 2018-02-19;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia
    Authors: A McDonough, RV Lee, S Noor, C Lee, T Le, M Iorga, JLH Phillips, S Murphy, T Möller, JR Weinstein
    J. Neurosci., 2017-07-26;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  7. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
    Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
    J. Immunol., 2017-06-02;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Bioassay
  8. ATF3 Is a Key Regulator of Macrophage IFN Responses.
    Authors: Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D
    J Immunol, 2015-09-28;195(9):4446-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii.
    Authors: Majumdar, Tanmay, Chattopadhyay, Saurabh, Ozhegov, Evgeny, Dhar, Jayeeta, Goswami, Ramansu, Sen, Ganes C, Barik, Sailen
    PLoS Pathog, 2015-03-26;11(3):e1004779.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.
    Authors: Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A, Leo O
    J Biol Chem, 2014-08-01;289(38):26642-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
    Authors: Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V
    J Immunol, 2014-03-19;192(8):3618-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
    Authors: Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K
    Proc Natl Acad Sci U S A, 2014-01-27;111(8):3068-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Optineurin insufficiency impairs IRF3 but not NF-kappaB activation in immune cells.
    Authors: Munitic I, Giardino Torchia M, Meena N, Zhu G, Li C, Ashwell J
    J Immunol, 2013-11-15;191(12):6231-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.
    Authors: Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA
    Immunol. Cell Biol., 2010-12-21;89(0):706-15.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Developmet
  16. TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis.
    Authors: Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H
    J. Immunol., 2010-11-22;186(1):556-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
    Authors: Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R
    Biochem. Biophys. Res. Commun., 2009-01-09;379(4):964-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
    Authors: Guo B, Chang EY, Cheng G
    J. Clin. Invest., 2008-05-01;118(5):1680-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3.
    Authors: Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, Willems F, Goldman M, Goriely S
    J. Immunol., 2007-06-15;178(12):7607-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
    Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
    Blood, 2006-05-23;108(6):2041-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Differential Growth of IFN-beta-Engineered Tumor Cells in Nude and IFN Receptor-Null Mice.
    Authors: Zhang F, Lee J, Wang D, Dong Z
    J. Interferon Cytokine Res., 2006-02-01;26(2):108-18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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