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Recombinant Mouse IGF-I/IGF-1 Protein, CF

Catalog #: 791-MG
74 Citations Datasheet / COA / SDS
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791-MG-050
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Recombinant Mouse IGF-I/IGF-1 Protein Bioactivity
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Citations (74)
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse IGF-I/IGF-1 Protein, CF Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 0.4-2 ng/mL.
Source
E. coli-derived mouse IGF-I/IGF-1 protein
Gly33-Ala102
Accession #
Q8CAR0
N-terminal Sequence
Analysis
Gly33
Predicted Molecular Mass
7.6 kDa

Product Datasheets

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791-MG

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

791-MG

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse IGF-I/IGF-1 Protein Bioactivity View Larger

Recombinant Mouse IGF-I/IGF-1 (Catalog # 791-MG) stimulates cell proliferation in a serum-free assay using the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.4-2 ng/mL.

SDS-PAGE Recombinant Mouse IGF-I/IGF-1 Protein SDS-PAGE View Larger

1 µg/lane of Recombinant Mouse IGF-I/IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 8 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IGF-I/IGF-1

Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I/IGF-1 is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I/IGF-1 is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I/IGF-1 shares 94% and 99% aa sequence identity with human and rat IGF-I/IGF-1, respectively (2), and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II/IGF-2. Circulating IGF-I/IGF-1 is produced by hepatocytes, while local IGF-I/IGF-1 is produced by many other tissues in which it has paracrine effects (1). IGF-I/IGF-1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I/IGF-1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I/IGF-1 association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10).

References
  1. Philippou, A. et al. (2007) In Vivo 21:45.
  2. Bell, G.I. et al. (1986) Nucleic Acids Res. 14:7873.
  3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
  4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
  5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
  6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
  7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
  8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
  9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
  10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.
Long Name
Insulin-like Growth Factor I/Insulin-like Growth Factor 1
Entrez Gene IDs
3479 (Human); 16000 (Mouse); 24482 (Rat)
Alternate Names
IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C

Citations for Recombinant Mouse IGF-I/IGF-1 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

74 Citations: Showing 1 - 10
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  1. Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons
    Authors: Andries, L;Kancheva, D;Masin, L;Scheyltjens, I;Van Hove, H;De Vlaminck, K;Bergmans, S;Claes, M;De Groef, L;Moons, L;Movahedi, K;
    Acta neuropathologica communications
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  2. Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche
    Authors: Haensel, D;Daniel, B;Gaddam, S;Pan, C;Fabo, T;Bjelajac, J;Jussila, AR;Gonzalez, F;Li, NY;Chen, Y;Hou, J;Patel, T;Aasi, S;Satpathy, AT;Oro, AE;
    Nature communications
    Species: Mouse
    Sample Types: Organoid
    Applications: Cell Culture
  3. Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells
    Authors: KW Southerlan, Y Xu, DT Peters, X Wei, X Lin, Y Xiang, K Fei, LA Olivere, JM Morowitz, J Otto, Q Dai, CD Kontos, Y Diao
    bioRxiv : the preprint server for biology, 2023-04-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke
    Authors: X Hong, Y Jian, S Ding, J Zhou, X Zheng, H Zhang, B Zhou, C Zhuang, J Wan, X Tong
    EBioMedicine, 2022-12-15;87(0):104406.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  5. An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis
    Authors: R Lesage, MN Ferrao Bla, R Narcisi, T Welting, GJVM van Osch, L Geris
    Bmc Biology, 2022-11-09;20(1):253.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis
    Authors: A Hiroto, WK Kim, A Pineda, Y He, DH Lee, V Le, AW Olson, J Aldahl, CH Nenninger, AJ Buckley, GQ Xiao, J Geradts, Z Sun
    Nature Communications, 2022-11-02;13(1):6552.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  7. RNA-seq transcriptomic analysis of 4-octyl itaconate repressing myogenic differentiation
    Authors: L Wang, Z Chen, Y Feng, R Wang, X Bai, W Liu, D Wang
    Archives of biochemistry and biophysics, 2022-09-29;0(0):109420.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
    Authors: MRF Gosselin, V Mournetas, M Borczyk, S Verma, A Occhipinti, J Róg, L Bozycki, M Korostynsk, SC Robson, C Angione, C Pinset, DC Gorecki
    Elife, 2022-09-27;11(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders
    Authors: ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen
    Nature Neuroscience, 2022-08-30;25(9):1163-1178.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways
    Authors: SJ Cha, X Yu, BD Gregory, YS Lee, T Ishino, RO Opoka, CC John, M Jacobs-Lor
    MBio, 2022-01-25;0(0):e0370821.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  11. Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity
    Authors: R Deshycka, V Sudaryo, NJ Huang, Y Xie, LY Smeding, MK Choi, HL Ploegh, HF Lodish, N Pishesha
    PLoS ONE, 2021-11-03;16(11):e0259353.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging
    Authors: P Maity, K Singh, L Krug, A Koroma, A Hainzl, W Bloch, S Kochanek, M Wlaschek, M Schorpp-Ki, P Angel, A Ignatius, H Geiger, K Scharffett
    Cell Reports, 2021-08-31;36(9):109634.
    Species: Transgenic Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  13. Muscle insulin-like growth factor-I modulates murine craniofacial bone growth
    Authors: HJ Kok, CN Crowder, L Koo Min Ch, HY Choi, N Lin, ER Barton
    European cells & materials, 2021-07-19;41(0):72-89.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: Western Blot Control
  14. Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells
    Authors: M Mohrin, J Liu, J Zavala-Sol, S Bhargava, J Maxwell Tr, A Brito, D Hu, D Brooks, G Koukos, L Alabdulaal, JS Paw, K Hake, G Kolumam, ML Bouxsein, R Baron, Y Kutskova, A Freund
    Aging Cell, 2021-02-09;0(0):e13313.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea
    Authors: M Kubota, M Scheibinge, TA Jan, S Heller
    Cell Reports, 2021-01-19;34(3):108646.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  16. Insulin inhibits inflammation-induced cone death in retinal detachment
    Authors: JB Conart, G Blot, S Augustin, G Millet-Pue, C Roubeix, F Beguier, H Charles-Me, S Touhami, JA Sahel, JP Berrod, T Léveillard, X Guillonnea, C Delarasse, F Sennlaub
    J Neuroinflammation, 2020-11-26;17(1):358.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  17. Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice
    Authors: J Xu, X Wang, J Chen, S Chen, Z Li, H Liu, Y Bai, F Zhi
    Theranostics, 2020-10-30;10(26):12204-12222.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  18. Resveratrol suppresses insulin-like growth factor I-induced osteoblast migration: attenuation of the p44/p42 MAP kinase pathway
    Authors: T Hioki, T Kawabata, G Sakai, K Fujita, G Kuroyanagi, R Matsushima, W Kim, T Otsuka, H Iida, H Tokuda, O Kozawa
    Biosci. Biotechnol. Biochem., 2020-08-30;0(0):1-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells
    Authors: AL Gill, MZ Wang, B Levine, A Premasiri, FG Vieira
    Int J Mol Sci, 2019-12-11;20(24):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway
    Authors: S Li, Z Yi, M Deng, MJ Scott, C Yang, W Li, Z Lei, NM Santerre, P Loughran, TR Billiar
    JCI Insight, 2019-11-14;4(22):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Food deprivation during active phase induces skeletal muscle atrophy via IGF-1 reduction in mice
    Authors: T Abe, R Kazama, H Okauchi, K Oishi
    Arch. Biochem. Biophys., 2019-10-19;0(0):108160.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  22. Insulin-like growth factor 1 stimulates the angiogenic activity of adipose tissue-derived microvascular fragments
    Authors: MW Laschke, E Kontaxi, C Scheuer, A He beta, P Karschnia, MD Menger
    J Tissue Eng, 2019-09-27;10(0):2041731419879.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  23. Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis
    Authors: SK Nandakumar, SK McFarland, LM Mateyka, CA Lareau, JC Ulirsch, LS Ludwig, G Agarwal, JM Engreitz, B Przychodze, M McConkey, GS Cowley, JG Doench, JP Maciejewsk, BL Ebert, DE Root, VG Sankaran
    Elife, 2019-05-09;8(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth
    Authors: I Meln, G Wolff, T Gajek, J Koddebusch, S Lerch, L Harbrecht, W Hong, I Bayindir-B, D Krunic, HG Augustin, A Vegiopoulo
    Mol Metab, 2019-04-05;24(0):139-148.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Insulin-like growth factor 1 modulates bioengineered tooth morphogenesis
    Authors: T Oyanagi, N Takeshita, M Hara, E Ikeda, T Chida, D Seki, M Yoshida, M Seiryu, I Takano, S Kimura, M Oshima, T Tsuji, T Takano-Yam
    Sci Rep, 2019-01-23;9(1):368.
    Species: Mouse
    Sample Types: Biofilm
    Applications: Bioassay
  26. Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice
    Authors: L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang
    Aging (Albany NY), 2018-12-04;0(0):.
    Species: Mouse
    Sample Types:
  27. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
    Authors: SY Lee, ED Abel, F Long
    Nat Commun, 2018-11-16;9(1):4831.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion
    Authors: LE Hillers, JV D'Amato, T Chamberlin, G Paderta, LM Arendt
    Neoplasia, 2018-10-12;20(11):1161-1174.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
    Authors: AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar
    Nat Commun, 2018-09-13;9(1):3708.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  30. Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells
    Authors: A Rasheed, R Tsai, CL Cummins
    J Am Heart Assoc, 2018-05-08;7(10):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation
    Authors: L Decourtye, M Clemessy, E Mire, T Ledent, L Périn, IC Robinson, Y Le Bouc, L Kappeler
    PLoS ONE, 2018-02-21;13(2):e0193196.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  32. Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin
    Authors: NJ Huang, N Pishesha, J Mukherjee, S Zhang, R Deshycka, V Sudaryo, M Dong, CB Shoemaker, HF Lodish
    Nat Commun, 2017-09-04;8(1):423.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction
    Authors: R Cintron-Co, M Sanchez-Al, W Nguyen, S Mori, R Gonzalez-R, T Lien, T Bartfai, S Aïd, JC François, M Holzenberg, B Conti
    Proc. Natl. Acad. Sci. U.S.A., 2017-08-21;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres
    Authors: T Iki, M Tanaka, SI Kitajiri, T Kita, Y Kawasaki, A Mizukoshi, W Fujibuchi, T Nakagawa, T Nakahata, J Ito, K Omori, MK Saito
    PLoS ONE, 2017-06-29;12(6):e0179901.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  35. IGFBP7 Deletion Promotes Hepatocellular Carcinoma
    Authors: M Akiel, C Guo, X Li, D Rajasekara, RG Mendoza, CL Robertson, N Jariwala, F Yuan, MA Subler, J Windle, DK Garcia, Z Lai, HH Chen, Y Chen, S Giashuddin, PB Fisher, XY Wang, D Sarkar
    Cancer Res., 2017-06-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway
    Authors: R Garg, JM Blando, CJ Perez, MC Abba, F Benavides, MG Kazanietz
    Cell Rep, 2017-04-11;19(2):375-388.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis
    Authors: L Chen, W Zeng, B Yang, X Cui, C Feng, L Wang, H Wang, X Zhou, P Li, F Lv, T Li
    Am J Transl Res, 2017-03-15;9(3):1500-1508.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
    Authors: S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase
    Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;114(12):E2486-E2493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors
    Authors: G Valenti, HM Quinn, GJ Heynen, L Lan, JD Holland, R Vogel, A Wulf-Golde, W Birchmeier
    Cancer Res, 2017-02-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice
    Authors: Aiko Inoue
    J Cachexia Sarcopenia Muscle, 2016-11-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
  41. EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
    Nat Commun, 2016-11-29;7(0):13685.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination with Cell Polarization During Ameloblast Differentiation
    J Bone Miner Res, 2016-10-26;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  43. Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro
    PLoS ONE, 2016-10-18;11(10):e0164579.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells
    Authors: MC Fernandez, R Rayes, B Ham, N Wang, F Bourdeau, S Milette, M Lllemann, N Bird, A Majeed, J Xu, T Kisselova, P Brodt
    Oncotarget, 2016-10-12;8(32):52281-52293.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages
    Authors: L R Batista-Si
    Sci Rep, 2016-06-10;6(0):27632.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction
    Authors: Thor Tejada
    Proc Natl Acad Sci USA, 2016-06-06;0(0):.
    Species: Mouse
    Sample Types: Protein
    Applications: Bioassay
  47. Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy
    Authors: T Tando, A Hirayama, M Furukawa, Y Sato, T Kobayashi, A Funayama, A Kanaji, W Hao, R Watanabe, M Morita, T Oike, K Miyamoto, T Soga, M Nomura, A Yoshimura, M Tomita, M Matsumoto, M Nakamura, Y Toyama, T Miyamoto
    J. Biol. Chem., 2016-04-15;291(23):12184-94.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Bioassay
  48. PTH Promotes Bone Anabolism by Stimulating Aerobic Glycolysis via IGF Signaling.
    Authors: Esen E, Lee S, Wice B, Long F
    J Bone Miner Res, 2015-07-14;30(11):1959-68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Proliferation of cultured mouse choroid plexus epithelial cells.
    Authors: Barkho B, Monuki E
    PLoS ONE, 2015-03-27;10(3):e0121738.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. TGFbeta signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.
    Authors: Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, Novitskiy S
    PLoS ONE, 2015-01-28;10(1):e0117908.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment.
    Authors: Chen H, Wang S, Zhang J, Ren X, Zhang R, Shi W, Lv Y, Zhou Y, Yan X, Chen L, He L, Zhang B, Nan X, Yue W, Li Y, Pei X
    Sci Rep, 2014-08-28;4(0):6222.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Intra-myocardial injection of both growth factors and heart derived Sca-1+/CD31- cells attenuates post-MI LV remodeling more than does cell transplantation alone: neither intervention enhances functionally significant cardiomyocyte regeneration.
    Authors: Wang X, Li Q, Hu Q, Suntharalingam P, From A, Zhang J
    PLoS ONE, 2014-06-11;9(2):e95247.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Comparing the cultivated cochlear cells derived from neonatal and adult mouse.
    Authors: Lou, Xiangxin, Dong, Youyi, Xie, Jing, Wang, Xianliu, Yang, Lianglia, Tokuda, Masaaki, Zhang, Yanzhong
    J Transl Med, 2014-05-29;12(0):150.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.
    Authors: Harvey A, Lashinger L, Hays D, Harrison L, Lewis K, Fischer S, Hursting S
    PLoS ONE, 2014-05-07;9(5):e94151.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. HGF signaling impacts severity of Pseudomonas aeruginosa keratitis.
    Authors: Jiang X, McClellan S, Barrett R, Foldenauer M, Hazlett L
    Invest Ophthalmol Vis Sci, 2014-04-09;55(4):2180-90.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  56. G(i)alpha proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells.
    Authors: Wang Z, Dela Cruz R, Ji F, Guo S, Zhang J, Wang Y, Feng G, Birnbaumer L, Jiang M, Chu W
    Cell Commun Signal, 2014-02-13;12(0):10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Myostatin stimulates, not inihibits, C2C12 myoblast proliferation.
    Authors: Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T
    Endocrinology, 2014-01-01;155(3):670-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Recombinant insulin-like growth factor-1 activates satellite cells in the mouse urethral rhabdosphincter.
    Authors: Wei W, Howard P, Macarak E
    BMC Urol, 2013-11-26;13(0):62.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  59. Exercise induces hippocampal BDNF through a PGC-1alpha/FNDC5 pathway.
    Authors: Wrann C, White J, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin J, Greenberg M, Spiegelman B
    Cell Metab, 2013-10-10;18(5):649-59.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  60. BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells.
    Authors: Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L
    Exp Cell Res, 2013-09-27;320(1):54-61.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
    Authors: Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H
    Stem Cells, 2013-04-01;31(4):627-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs.
    Authors: Guo T, Landsman L, Li N, Hebrok M
    Diabetes, 2013-01-10;62(5):1581-92.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  63. Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation.
    Authors: Tucker B, Anfinson K, Mullins R, Stone E, Young M
    Stem Cells Transl Med, 2012-12-27;2(1):16-24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function.
    Authors: Takehara, Yuji, Yabuuchi, Akiko, Ezoe, Kenji, Kuroda, Tomoko, Yamadera, Rie, Sano, Chiaki, Murata, Nana, Aida, Takuya, Nakama, Ken, Aono, Fumihito, Aoyama, Naoki, Kato, Keiich, Kato, Osamu
    Lab Invest, 2012-11-19;93(2):181-93.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  65. Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice.
    Authors: Zhao H, Zhao X, Cao X, Wu G
    Immun Ageing, 2012-05-28;9(1):12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. IGFBP-3 is a metastasis suppression gene in prostate cancer.
    Authors: Mehta HH, Gao Q, Galet C
    Cancer Res., 2011-06-22;71(15):5154-63.
    Applications: ELISA (Standard)
  67. Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors.
    Authors: Sanchez-Alavez M, Osborn O, Tabarean IV
    J. Biol. Chem., 2011-02-17;286(17):14983-90.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. A critical role for IGF-II in memory consolidation and enhancement.
    Authors: Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM
    Nature, 2011-01-27;469(7331):491-7.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  69. Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.
    Authors: Yamada PM, Mehta HH, Hwang D
    Endocrinology, 2010-10-06;151(12):5741-50.
    Applications: ELISA (Standard)
  70. Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma.
    Authors: Hu J, Dong A, Fernandez-Ruiz V, Shan J, Kawa M, Martinez-Anso E, Prieto J, Qian C
    Cancer Res., 2009-08-18;69(17):6951-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation.
    Authors: Ostrovsky O, Ahmed NT, Argon Y
    Mol. Biol. Cell, 2009-01-21;20(6):1855-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
    Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
    Am. J. Respir. Crit. Care Med., 2008-04-24;178(2):149-57.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  73. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.
    Authors: Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glode LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R
    Cancer Res., 2007-11-15;67(22):11083-91.
    Applications: ELISA (Standard)
  74. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.
    Authors: Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M
    Mol. Cell. Neurosci., 2005-11-16;31(1):149-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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