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Recombinant Mouse IL-17A Protein

Catalog #: 421-ML
92 Citations 7 Reviews Datasheet / COA / SDS
Newer Version Available: 7956-ML/CF
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Carrier Free

Catalog # Availability Size / Price Qty
421-ML-025/CF
421-ML-010/CF
421-ML-100/CF

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Catalog # Availability Size / Price Qty
421-ML-025
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Citations (92)
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Reviews (7)
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Recombinant Mouse IL-17A Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811. The ED50 for this effect is 0.25-1.25 ng/mL.
Source
E. coli-derived mouse IL-17/IL-17A protein
Thr22-Ala158
Accession #
Q62386.1
N-terminal Sequence
Analysis
Thr22
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
15.5 kDa (monomer)

Product Datasheets

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421-ML (with carrier)

Product Datasheet
COA
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421-ML/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

421-ML

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 25 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

421-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100 μg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-17/IL-17A

Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20 kDa glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold (1, 2). Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively (3, 4). IL-17A is secreted by Th17 cells, gamma /δ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells (2). It forms disulfide-linked homodimers as well as disulfide-linked heterodimers with IL-17F (5, 6). IL-17A exerts its effects through the transmembrane IL-17RA in complex with IL-17RC or IL-17RD (7, 8). Both IL-17RA and IL-17RC are required for responsiveness to heterodimeric IL-17A/F (7). IL-17A promotes protective mucosal and epidermal inflammation in response to microbial infection (9-12). It induces chemokine production, neutrophil influx, and the production of antibacterial peptides (9-11). IL-17A/F likewise induces neutrophil migration, but IL-17F does not (11). IL-17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF-alpha induced shock (Fossiez, 14). In contrast, it can protect against the progression of colitis by limiting chronic inflammation (12). IL-17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity (15, 16). IL‑17A has been shown to exert either tumorigenic or anti-tumor effects (17, 18).

References
  1. Gaffen, S.L. (2009) Nat. Rev. Immunol. 9:556.
  2. Cua, D.J. and C.M. Tato (2010) Nat. Rev. Immunol. 10:479.
  3. Yao, Z. et al. (1996) Gene 168:223.
  4. Rouvier, E. et al. (1993) J. Immunol. 150:5445.
  5. Chang, S.H. and C. Dong (2007) Cell Res. 17:435.
  6. Wright, J.F. et al. (2007) J. Biol. Chem. 282:13447.
  7. Wright, J.F. et al. (2008) J. Immunol. 181:2799.
  8. Rong, Z. et al. (2009) Cell Res. 19:208.
  9. Cho, J.S. et al. (2010) J. Clin. Invest. 120:1762.
  10. Liang, S.C. et al. (2006) J. Exp. Med. 203:2271.
  11. Liang, S.C. et al. (2007) J. Immunol. 179:7791.
  12. O’Connor Jr., W. et al. (2009) Nat. Immunol. 10:603.
  13. Fossiez, F. et al. (1996) J. Exp. Med. 183:2593.
  14. Takahashi, N. et al. (2008) J. Exp. Med. 205:1755.
  15. Hsu, H. et al. (2008) Nat. Immunol. 9:166.
  16. Rohn, T.A. et al. (2006) Eur. J. Immunol. 36:2857.
  17. Wang, L. et al. (2009) J. Exp. Med. 206:1457.
  18. Kryczek, I. et al. (2009) Blood 114:357.
Long Name
Interleukin 17
Entrez Gene IDs
3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)
Alternate Names
CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A

Citations for Recombinant Mouse IL-17A Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

92 Citations: Showing 1 - 10
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  1. Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity
    Authors: Zhang, H;Xue, K;Li, W;Yang, X;Gou, Y;Su, X;Qian, F;Sun, L;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Candida albicans Promotes Oral Cancer via IL-17A/IL-17RA-Macrophage Axis
    Authors: X Wang, S Wu, W Wu, W Zhang, L Li, Q Liu, Z Yan
    MBio, 2023-04-17;0(0):e0044723.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Activation of the IL-17/TRAF6/NF-kappaB pathway is implicated in Abeta-induced neurotoxicity
    Authors: Y Liu, Y Meng, C Zhou, J Yan, C Guo, W Dong
    Bmc Neuroscience, 2023-02-23;24(1):14.
    Species: Mouse
    Sample Types: Whole Cells
  4. Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
    Authors: J Youwakim, D Vallerand, H Girouard
    International Journal of Molecular Sciences, 2023-02-16;24(4):.
    Species: Mouse, Transgenic Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  5. Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
    Authors: FP Veras, GA Publio, BM Melo, DS Prado, T Norbiato, NT Cecilio, C Hiroki, LEA Damasceno, R Jung, JE Toller-Kaw, TV Martins, SF Assunção, D Lima, MG Alves, GV Vieira, LA Tavares, ALR Alves-Reze, SH Karbach, HI Nakaya, TM Cunha, CS Souza, FQ Cunha, KU Sales, A Waisman, JC Alves-Filh
    Cell Reports, 2022-12-27;41(13):111897.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. IL-17A drives cognitive aging probably via inducing neuroinflammation and theta oscillation disruption in the hippocampus
    Authors: Y Li, M Mao, L Zhu, Q Sun, J Tong, Z Zhou
    Oncogene, 2022-05-31;108(0):108898.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  7. Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis
    Authors: M Di Filippo, A Mancini, L Bellingacc, L Gaetani, P Mazzocchet, T Zelante, L La Barbera, A De Luca, M Tantucci, A Tozzi, V Durante, M Sciaccalug, A Megaro, D Chiasserin, N Salvadori, V Lisetti, E Portaccio, C Costa, P Sarchielli, MP Amato, L Parnetti, MT Viscomi, L Romani, P Calabresi
    Cell Reports, 2021-12-07;37(10):110094.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  8. Preclinical development of a bispecific TNFalpha/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease
    Authors: KJ Roberts, MF Cubitt, TM Carlton, L Rodrigues-, L Maggiore, R Chai, S Clare, K Harcourt, TT MacDonald, KP Ray, A Vossenkämp, MR West, JS Crowe
    Scientific Reports, 2021-09-30;11(1):19422.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: ELISA Standard
  9. Gut-licensed IFN&gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
    Authors: LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana
    Nature, 2021-01-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
    Authors: G Gupta, Z Mou, P Jia, R Sharma, R Zayats, SM Viana, L Shan, A Barral, VS Boaventura, TT Murooka, A Soussi-Gou, CI de Oliveir, JE Uzonna
    Cell Reports, 2020-12-15;33(11):108513.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-kappaB/iNOS/NO-dependent cardiomyocyte contractile depression and death
    Authors: T Yoshida, NA Das, AJ Carpenter, R Izadpanah, SA Kumar, S Gautam, SB Bender, U Siebenlist, B Chandrasek
    Cell. Signal., 2020-06-15;73(0):109690.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis
    Authors: M Li, C Li, X Wu, T Chen, L Ren, B Xu, J Cao
    Crit Care, 2020-05-27;24(1):268.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  13. Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice
    Authors: H Koriyama, Y Ikeda, H Nakagami, M Shimamura, S Yoshida, H Rakugi, R Morishita
    Vaccines (Basel), 2020-02-12;8(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis
    Authors: J Li, P Kong, C Chen, J Tang, X Jin, J Yan, Y Wang
    Oxid Med Cell Longev, 2019-08-18;2019(0):1475729.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. T cell deletion of MyD88 connects IL-17 and IkBz to RAS oncogenesis
    Authors: C Cataisson, R Salcedo, AM Michalowsk, M Klosterman, S Naik, L Li, MJ Pan, A Sweet, JQ Chen, LG Kostecka, M Karwan, L Smith, RM Dai, CA Stewart, L Lyakh, WT Hsieh, A Khan, H Yang, M Lee, G Trinchieri, SH Yuspa
    Mol. Cancer Res., 2019-06-04;0(0):.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection
    Authors: A Zychlinsky, M Rousseau, L Lacerda Ma, T Canton, CR Consiglio, ML Albert, M Fontes, D Duffy, MA Ingersoll
    JCI Insight, 2019-05-30;5(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  17. IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
    Authors: H Katsura, Y Kobayashi, PR Tata, BLM Hogan
    Stem Cell Reports, 2019-03-28;0(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  18. Bmi1 Regulates I?B? Degradation via Association with the SCF Complex
    Authors: Y Okuyama, Y Tanaka, JJ Jiang, D Kamimura, A Nakamura, M Ota, T Ohki, D Higo, H Ogura, N Ishii, T Atsumi, M Murakami
    J. Immunol., 2018-09-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Presenilin 1 Regulates NF-?B Activation via Association with Breakpoint Cluster Region and Casein Kinase II
    Authors: Y Tanaka, L Sabharwal, M Ota, I Nakagawa, JJ Jiang, Y Arima, H Ogura, M Okochi, M Ishii, D Kamimura, M Murakami
    J. Immunol., 2018-09-10;0(0):.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  20. IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model
    Authors: B Zwarycz, AD Gracz, KR Rivera, IA Williamson, LA Samsa, J Starmer, MA Daniele, L Salter-Cid, Q Zhao, ST Magness
    Cell Mol Gastroenterol Hepatol, 2018-07-04;7(1):1-17.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  21. Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection
    Authors: L Markey, L Shaban, ER Green, KP Lemon, J Mecsas, CA Kumamoto
    Gut Microbes, 2018-05-30;0(0):0.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  22. Electrophilic properties of itaconate and derivatives regulate the�I?B?-ATF3 inflammatory axis
    Authors: M Bambouskov, L Gorvel, V Lampropoul, A Sergushich, E Loginichev, K Johnson, D Korenfeld, ME Mathyer, H Kim, LH Huang, D Duncan, H Bregman, A Keskin, A Santeford, RS Apte, R Sehgal, B Johnson, GK Amarasingh, MP Soares, T Satoh, S Akira, T Hai, C de Guzman, K Auclair, TP Roddy, SA Biller, M Jovanovic, E Klechevsky, KM Stewart, GJ Randolph, MN Artyomov
    Nature, 2018-04-18;556(7702):501-504.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function
    Authors: AS Chitre, MG Kattah, YY Rosli, M Pao, M Deswal, SG Deeks, PW Hunt, M Abdel-Mohs, LJ Montaner, CC Kim, A Ma, M Somsouk, JM McCune
    PLoS Pathog., 2018-03-05;14(3):e1006806.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  24. Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy
    Authors: C Navarrete, F Carrillo-S, B Palomares, M Mecha, C Jiménez-Ji, L Mestre, A Feliú, ML Bellido, BL Fiebich, G Appendino, MA Calzado, C Guaza, E Muñoz
    J Neuroinflammation, 2018-03-01;15(1):64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis
    Authors: A Mancini, M Tantucci, P Mazzocchet, A de Iure, V Durante, L Macchioni, C Giampà, A Alvino, L Gaetani, C Costa, A Tozzi, P Calabresi, M Di Filippo
    Neurobiol. Dis., 2018-01-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  26. Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation
    Authors: A Hammer, A Schliep, S Jörg, A Haghikia, R Gold, M Kleinewiet, DN Müller, RA Linker
    J Neuroinflammation, 2017-09-12;14(1):184.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit
    Authors: Y Arima, T Ohki, N Nishikawa, K Higuchi, M Ota, Y Tanaka, J Nio-Kobaya, M Elfeky, R Sakai, Y Mori, T Kawamoto, A Stofkova, Y Sakashita, Y Morimoto, M Kuwatani, T Iwanaga, Y Yoshioka, N Sakamoto, A Yoshimura, M Takiguchi, S Sakoda, M Prinz, D Kamimura, M Murakami
    Elife, 2017-08-15;6(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  28. Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity
    Authors: T Eddens, W Elsegeiny, ML Garcia-Her, P Castillo, G Trevejo-Nu, K Serody, BT Campfield, SA Khader, K Chen, J Rangel-Mor, JK Kolls
    Cell Rep, 2017-03-28;18(13):3078-3090.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  29. Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF
    Authors: AB Roos, M Mori, HK Gura, A Lorentz, L Bjermer, HJ Hoffmann, JS Erjefält, MR Stampfli
    Respir. Res, 2017-03-15;18(1):48.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire
    Authors: David A Hildeman
    J. Immunol., 2016-11-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization
    Sci Rep, 2016-11-03;6(0):36598.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Synovium-Derived MicroRNAs Regulate Bone Pathways in Rheumatoid Arthritis
    J Bone Miner Res, 2016-10-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II
    J Immunol, 2016-09-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention
    Authors: Daniel Hsu
    Infect Immun, 2016-08-19;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  35. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis
    Authors: Jung-Yeon Lim
    Sci Rep, 2016-06-01;6(0):26851.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  36. Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
    Authors: Reynolds J, Lee Y, Shi Y, Wang X, Angkasekwinai P, Nallaparaju K, Flaherty S, Chang S, Watarai H, Dong C
    Immunity, 2015-04-14;42(4):692-703.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate.
    Authors: Miljkovic D, Blazevski J, Petkovic F, Djedovic N, Momcilovic M, Stanisavljevic S, Jevtic B, Mostarica Stojkovic M, Spasojevic I
    J Immunol, 2015-02-13;194(6):2493-503.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Protective effect of a germline, IL-17-neutralizing antibody in murine models of autoimmune inflammatory disease.
    Authors: Dallenbach K, Maurer P, Rohn T, Zabel F, Kopf M, Bachmann M
    Eur J Immunol, 2015-01-23;45(4):1238-47.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  39. Temporal expression of growth factors triggered by epiregulin regulates inflammation development.
    Authors: Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, Sabharwal L, Jiang J, Kumai N, Miyasaka N, Sakoda S, Yamauchi-Takihara K, Ogura H, Hirano T, Murakami M
    J Immunol, 2015-01-02;194(3):1039-46.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  40. IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.
    Authors: Ha H, Wang H, Pisitkun P, Kim J, Tassi I, Tang W, Morasso M, Udey M, Siebenlist U
    Proc Natl Acad Sci U S A, 2014-08-04;111(33):E3422-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014-05-09;12(0):32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.
    Authors: Ardeljan, Daniel, Wang, Yujuan, Park, Stanley, Shen, Defen, Chu, Xi Kathy, Yu, Cheng-Ro, Abu-Asab, Mones, Tuo, Jingshen, Eberhart, Charles, Olsen, Timothy, Mullins, Robert F, White, Gary, Wadsworth, Sam, Scaria, Abraham, Chan, Chi-Chao
    PLoS ONE, 2014-04-29;9(4):e95900.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  43. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
    Authors: Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
    J Biol Chem, 2014-04-22;289(22):15621-30.
    Species: Bacteria - Porphyromonas gingivalis, Mouse
    Sample Types: Protein, Whole Cells
    Applications: Bioassay, Degradation
  44. A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis.
    Authors: Carrillo-Salinas F, Navarrete C, Mecha M, Feliu A, Collado J, Cantarero I, Bellido M, Munoz E, Guaza C
    PLoS ONE, 2014-04-11;9(4):e94733.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
    Authors: Sriskantharajah S, Guckel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis P, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley S
    J Immunol, 2014-03-17;192(8):3518-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control.
    Authors: Yang E, Lee J, Lee S, Kim E, Moon Y, Jung Y, Park S, Cho M
    PLoS ONE, 2014-02-18;9(2):e86062.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard)
  47. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
    Authors: Moon C, VanDussen K, Miyoshi H, Stappenbeck T
    Mucosal Immunol, 2013-11-13;7(4):818-28.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Rgs13 constrains early B cell responses and limits germinal center sizes.
    Authors: Hwang I, Hwang K, Park C, Harrison K, Kehrl J
    PLoS ONE, 2013-03-22;8(3):e60139.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Macrophages participate in IL-17-mediated inflammation.
    Authors: Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Cihakova D
    Eur. J. Immunol., 2012-01-23;42(3):726-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. IL-17RA signaling amplifies antibody-induced arthritis.
    Authors: Sadik CD, Kim ND, Alekseeva E, Luster AD
    PLoS ONE, 2011-10-20;6(10):e26342.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
    Authors: Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, Hara M
    J. Immunol., 2011-09-26;187(9):4818-25.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  53. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease.
    Authors: Whitehead GS, Wilson RH, Nakano K, Burch LH, Nakano H, Cook DN
    J. Allergy Clin. Immunol., 2011-09-08;129(1):207-15.e1-5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  54. IL-17 and VEGF are necessary for efficient corneal nerve regeneration.
    Authors: Li Z, Burns AR, Han L, Rumbaut RE, Smith CW
    Am. J. Pathol., 2011-03-01;178(3):1106-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  55. IL-17A and TNF-alpha Exert Synergistic Effects on Expression of CXCL5 by Alveolar Type II Cells In Vivo and In Vitro.
    Authors: Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, Zhang P, Favara M, Malcolm KC, Guttentag S, Worthen GS
    J. Immunol., 2011-01-31;186(5):3197-205.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  56. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans.
    Authors: Kagami S, Rizzo HL, Kurtz SE
    J. Immunol., 2010-10-04;185(9):5453-62.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  57. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis.
    Authors: Wondimu Z, Santodomingo-Garzon T, Le T, Swain MG
    Am. J. Pathol., 2010-09-16;177(5):2334-46.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  58. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.
    Authors: Blumberg H, Dinh H, Dean C, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE
    J. Immunol., 2010-09-10;185(7):4354-62.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  59. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
    Authors: Yoshizaki A, Yanaba K, Iwata Y
    J. Immunol., 2010-07-12;185(4):2502-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
    Authors: Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS
    J. Clin. Invest., 2010-04-01;120(5):1762-73.
    Species: Bacteria, Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  61. Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
    Authors: Moransard M, Sawitzky M, Fontana A, Suter T
    Glia, 2010-04-01;58(5):559-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis.
    Authors: Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F
    J. Immunol., 2010-03-24;184(0):5263-70.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  63. IL-23 is required for protection against systemic infection with Listeria monocytogenes.
    Authors: Meeks KD, Sieve AN, Kolls JK, Ghilardi N, Berg RE
    J. Immunol., 2009-12-15;183(12):8026-34.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA (Standard)
  64. Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection.
    Authors: Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke RA, Roy S
    Infect. Immun., 2009-12-07;78(2):830-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  65. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
    Authors: Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS
    Proc. Natl. Acad. Sci. U.S.A., 2009-08-17;106(35):14954-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness.
    Authors: Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN
    Am. J. Respir. Crit. Care Med., 2009-08-06;180(8):720-30.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  67. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
    Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
    J. Immunol., 2009-06-19;183(2):1291-300.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. IL-17 receptor signaling is required to control polymicrobial sepsis.
    Authors: Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B
    J. Immunol., 2009-06-15;182(12):7846-54.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  69. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.
    Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ
    Proc. Natl. Acad. Sci. U.S.A., 2009-03-16;106(14):5954-9.
    Species: Mouse
    Sample Types: In Vivo, N/A
    Applications: ELISA (Standard), In Vivo
  70. Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis.
    Authors: Ozment-Skelton TR, deFluiter EA, Ha T, Li C, Graves BM, Ferguson DA, Schweitzer JB, Preizsner J, Brown GD, Gordon S, Kalbfleisch JH, Williams DL
    Crit. Care Med., 2009-03-01;37(3):1038-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis.
    Authors: Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T
    Biochem. Biophys. Res. Commun., 2009-02-26;382(2):252-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
    Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
    J. Immunol., 2009-02-01;182(3):1617-30.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  73. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling.
    Authors: Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, Wang Y, Ren F, Zhang X, Hu J, Chang Z
    Cell Res., 2009-02-01;19(2):208-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation.
    Authors: Swaidani S, Bulek K, Kang Z, Liu C, Lu Y, Yin W, Aronica M, Li X
    J. Immunol., 2009-02-01;182(3):1631-40.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  75. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.
    Authors: Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y
    Immunity, 2009-01-16;30(1):108-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells.
    Authors: Nagata T, McKinley L, Peschon JJ, Alcorn JF, Aujla SJ, Kolls JK
    J. Immunol., 2008-12-01;181(11):7473-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Interleukin 17 sustains rather than induces inflammation.
    Authors: Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, D'Acquisto F
    Biochem. Pharmacol., 2008-11-25;77(5):878-87.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  78. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis.
    Authors: Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, Ohba M, Sueki H, Kokubu F, Hizawa N, Adachi M, Huang SK, Iijima M
    J. Invest. Dermatol., 2008-10-02;129(3):650-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  79. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
    Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
    J. Immunol., 2008-09-15;181(6):4279-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities.
    Authors: Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL
    J. Immunol., 2008-09-15;181(6):4299-310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse.
    Authors: Furze RC, Rankin SM
    FASEB J., 2008-05-28;22(9):3111-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  82. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
    Authors: Guo B, Chang EY, Cheng G
    J. Clin. Invest., 2008-05-01;118(5):1680-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2.
    Authors: Van de Wiele CJ, Marino JH, Tan C, Kneale HA, Weber J, Morelli JN, Davis BK, Taylor AA, Teague TK
    Cell. Immunol., 2008-03-05;250(1):31-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.
    Authors: Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK
    Nat. Med., 2008-02-10;14(3):275-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
    Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
    Eur. J. Immunol., 2007-10-01;37(10):2695-706.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis.
    Authors: Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, Ganea D
    J. Immunol., 2007-06-15;178(12):8138-47.
    Applications: ELISA (Standard)
  87. Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum.
    Authors: Witowski J, Ksiazek K, Warnecke C, Kuzlan M, Korybalska K, Tayama H, Wisniewska-Elnur J, Pawlaczyk K, Trominska J, Breborowicz A, Jorres A
    Kidney Int., 2007-01-17;71(6):514-25.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  88. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice.
    Authors: Nakae S, Suto H, Berry GJ, Galli SJ
    Blood, 2006-12-29;109(9):3640-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  89. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
    Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
    Am. J. Respir. Cell Mol. Biol., 2005-05-18;33(3):248-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. In vivo effects of interleukin-17 on haematopoietic cells and cytokine release in normal mice.
    Authors: Jovcic G, Bugarski D, Petakov M, Krstic A, Vlaski M, Stojanovic N, Milenkovic P
    Cell Prolif., 2004-12-01;37(6):401-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  91. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi.
    Authors: Burchill MA, Nardelli DT, England DM, DeCoster DJ, Christopherson JA, Callister SM, Schell RF
    Infect. Immun., 2003-06-01;71(6):3437-42.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  92. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
    Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
    J. Immunol., 2003-05-01;170(9):4665-72.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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