(S)-(-)-Bay K 8644

Catalog #: 1546
5 Citations Datasheet / COA / SDS

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(S)-(-)-Bay K 8644 | CAS No. 98625-26-4 | Cav1.x Channel Activators

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Description: CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644

Chemical Name: (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

Purity: ≥98%

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Product Details

Citations (5)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(S)-(-)-Bay K 8644 is a L-type Ca²⁺-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.

Racemate and (R)-(+)-Enantiomer also available.

Technical Data

M.Wt:

356.3

Formula:

C₁₆H₁₅F₃N₂O₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

98625-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.
Franckowiak et al.
Eur.J.Pharmacol., 1985;114:223
Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644.
O'Neill and Bolger
Brain Res.Bull., 1988;21:865
Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles.
Ravens and Schopper
Naunyn Schmiedebergs Arch.Pharmacol., 1990;341:232

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Citations for (S)-(-)-Bay K 8644

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Bay K 8644 include:

5 Citations: Showing 1 - 5

Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ-1 subunits.
Authors: Alles Et al.
Mol Pain 2018;14:1744806918765800
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions.
Authors: Wei Et al.
Sci Rep 2017;7:981
Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2.
Authors: Burtscher Et al.
Biochim Biophys Acta 2014;1838:2053
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Authors: Landstrom Et al.
Eneuro 2011;4:214
Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.
Authors: Chen Et al.
Nat Neurosci 2011;14:570

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