SR 16832
Chemical Name: 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
Purity: ≥98%
Biological Activity
SR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor.
Brust et al.
ACS Chem.Biol., 2017;12:969
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Citations for SR 16832
The citations listed below are publications that use Tocris products. Selected citations for SR 16832 include:
2 Citations: Showing 1 - 2
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SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.
Authors: Clary B Et al.
Cell Rep 2021;36:109345
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Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury.
Authors: Christine Et al.
Nat Commun 2020;11:2123
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