T 0070907
Chemical Name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide
Purity: ≥99%
Biological Activity
T 0070907 is a potent and selective irreversible PPARγ antagonist (IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits Rosiglitazone-induced adipogenesis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cultured Human Periosteum-Derived Cells Can Differentiate into Osteoblasts in a Perioxisome Proliferator-Activated Receptor Gamma-Mediated Fashion via Bone Morphogenetic Protein signaling
Int J Med Sci, 2016;13(11):806-818. -
T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities.
Lee et al.
J.Biol.Chem., 2002;277:19649 -
A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes.
Rockwell and Kaminski
J.Pharmacol.Exp.Ther., 2004;311:683 -
Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells.
Schaefer et al.
Cancer Res., 2005;65:2251 -
Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid.
Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito
Nutrients, 2017;0(0):2072-6643.
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Citations for T 0070907
The citations listed below are publications that use Tocris products. Selected citations for T 0070907 include:
5 Citations: Showing 1 - 5
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Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets
Authors: Fellous Et al.
Biochemical Pharmacology 2020;175
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Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling.
Authors: Kassotis Et al.
Sci Rep 2017;7:42104
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The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype.
Authors: Bullers Et al.
Tissue Eng Part A 2014;20:2390
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The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
Authors: Hamtiaux Et al.
BMC Cancer 2012;12:92
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Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
Authors: Hamtiaux Et al.
PLoS One 2011;6:e26823
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10 microM T 0070907 was used in the mouse and it blunt EC sprouting.
