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SSYA10-001

Catalog #: 7554 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7554/10
7554/50
SSYA10-001 | CAS No. 675104-49-1 | Antiviral Compounds
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Description: Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6

Chemical Name: 2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione

Purity: ≥98%

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Biological Activity

SSYA10-001 is a potent coronavirus helicase inhibitor (IC50 values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC50 = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC50 values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC50 = 8.95 μM). Also inhibits human papillomavirus E6 (IC50 = 10 μM)

Technical Data

M.Wt:
308.37
Formula:
C12H12N4O2S2
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
675104-49-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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