Antiviral Compounds: Products

Selective CCR5 antagonist

Inhibits hepatitis C viral life cycle; also α-crystallin (cryAB) chaperone

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

Toll-like receptor 7 (TLR7) agonist

Potent and selective VPAC2 agonist

Specific inhibitor of NF-κB activation

Non-selective P2 antagonist

Selective PC-PLC inhibitor

Toll-like receptor 7 (TLR7) agonist

Core binding factor inhibitor; attenuates hematopoiesis

mSTING agonist; induces antitumor immunological responses

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug

α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

Reverse transcriptase inhibitor

Potent CXCR4 antagonist

DNA polymerase α, δ and ε inhibitor

HIV-1 and HIV-2 protease inhibitor

Potent and selective HIV-1 and HIV-2 protease inhibitor

Influenza virus neuraminidase inhibitor; antiviral prodrug

Coronavirus PLpro inhibitor

Inosine monophosphatase dehydrogenase (IMPDH) inhibitor

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

BLT1/BLT2 receptor agonist and potent chemotactic factor

p53 activator. Also ROS scavenger

Potent HIV-1 protease inhibitor

HIV protease inhibitor

Blocks eIF4E activity; antiviral guanosine analog

2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis

Potent and selective PI 4-kinase IIIβ inhibitor

Potent and selective CCR5 and CCR2 chemokine receptor antagonist

Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates

Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses

Potent and selective hepatitis B virus inhibitor

Potent LSD1 inhibitor

Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral

Highly potent and selective HIV-1 protease inhibitor

Potent influenza virus neuraminidase inhibitor

Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

Viral RNA polymerase inhibitor

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral

Coronavirus Mpro inhibitor

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleoside

Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective

Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral

Potent and high affinity H2 biased inverse agonist

Potent and selective herpes simplex virus (HSV) helicase primase inhibitor

Inhibits coronavirus RNA replication; impairs double membrane vesicle (DMV) formation