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Suramin hexasodium salt

Catalog #: 1472
24 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1472/50
Suramin hexasodium salt | CAS No. 129-46-4 | P2X Receptor Antagonists
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Description: Non-selective P2 antagonist

Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

Purity: ≥98%

Product Details
Citations (24)
Reviews
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Biological Activity

Suramin hexasodium salt is a non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels and acts as a competitive α1β2γ2 GABAA receptor antagonist. Anticancer, antiviral and antiparasitic agent.

This product may be supplied with a high degree of hydration and some residual NaCl, the amounts of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Technical Data

M.Wt:
1429.15
Formula:
C51H34N6Na6O23S6
Solubility:
Soluble to 50 mg/ml in water and to 5 mg/ml in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
129-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Suramin hexasodium salt

The citations listed below are publications that use Tocris products. Selected citations for Suramin hexasodium salt include:

24 Citations: Showing 1 - 10

  1. Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
    Authors: Dosch Et al.
    Elife  2019;8
  2. Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair.
    Authors: Mikolajewicz Et al.
    Elife  2018;7
  3. Role of purinergic signaling in experimental pneumococcal meningitis.
    Authors: Zierhut
    Sci Rep  2017;7:44625
  4. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.
    Authors: Conley
    PLoS One  2017;12(11):e0187481
  5. In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex.
    Authors: Yuryev Et al.
    Front Cell Neurosci  2016;9:500
  6. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
    Authors: Zhang Et al.
    Sci Rep  2016;6:28938
  7. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
    Authors: Ledderose Et al.
    J Infect Dis  2016;213:456
  8. Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.
    Authors: Naviaux Et al.
    Mol Autism  2015;6:1
  9. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Mol Neurosci  2015;4
  10. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  11. Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage.
    Authors: Makris Et al.
    Tissue Eng Part A  2015;21:884
  12. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  13. Diadenosine tetraphosphate contributes to CB-induced tear secretion.
    Authors: Fonseca Et al.
    Purinergic Signal  2015;11:87
  14. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.
    Authors: Naviaux Et al.
    Transl Psychiatry  2014;4:e400
  15. Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.
    Authors: Naviaux Et al.
    PLoS One  2013;8:e57380
  16. Neural progenitors organize in small-world networks to promote cell proliferation.
    Authors: Malmersjö Et al.
    J Pharmacol Exp Ther  2013;110:E1524
  17. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol  2012;92:787
  18. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
    Authors: Rodríguez-Zayas Et al.
    Am J Physiol Heart Circ Physiol  2012;46:167
  19. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol  2012;188:4488
  20. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen  2012;15:359
  21. Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes.
    Authors: Sivaramakrishnan Et al.
    J Cell Sci  2012;125:4567
  22. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
    Authors: Thrane Et al.
    Proc Natl Acad Sci U S A  2011;108:846
  23. Modulation of agonist binding to human DA receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog.
    Authors: Verma Et al.
    Elife  2005;315:1228
  24. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
    Authors: Price Et al.
    Br J Pharmacol  2004;142:257

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