Home / MEK Inhibitors / U0126

U0126

Catalog #: 1144
131 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1144/5
1144/25
U0126 | CAS No. 109511-58-2 | MEK Inhibitors
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Description: Potent, selective inhibitor of MEK1 and 2

Chemical Name: 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene

Product Details
Citations (131)
Reviews (1)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

U0126 is a potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state.

Negative Control also available.

Technical Data

M.Wt:
380.48
Formula:
C18H16N6S2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
109511-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state.
    Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, Taylor C, Ghosh S, Price T
    Mol Pain, 2013;9(0):12.
  2. Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation
    H Wang, S Liu, S Liu, W Wei, X Zhou, F Lin, J Wang, J Chen, G Zhang, Y Pang
    PLoS ONE, 2017;12(6):e0178530.
  3. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells
    C Kim, B Hu, RR Jadhav, J Jin, H Zhang, MM Cavanagh, RS Akondy, R Ahmed, CM Weyand, JJ Goronzy
    Cell Rep, 2018;25(8):2148-2162.e5.
  4. TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E
    BMC Cancer, 2014;14(0):113.
  5. Specific activation of the G protein-coupled receptor BNGR-A21 by the neuropeptide corazonin from the silkworm, Bombyx mori, dually couples to the G(q) and G(s) signaling cascades.
    Yang, Jingwen, Huang, Haishan, Yang, Huipeng, He, Xiaobai, Jiang, Xue, Shi, Ying, Alatangaole, Damirin, Shi, Liangen, Zhou, Naiming
    J Biol Chem, 2013;288(17):11662-75.
  6. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  7. JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner.
    Lin Y, Zhang B, Liang H, Lu Y, Ai X, Zhang B, Chen X
    Mol Med Rep, 2013;8(6):1623-9.
  8. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes.
    Maury Y, Come J, Piskorowski R, Salah-Mohellibi N, Chevaleyre V, Peschanski M, Martinat C, Nedelec S
    Nat Biotechnol, 2015;33(1):89-96.
  9. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Lourenco S, Teixeira V, Kalber T, Jose R, Floto R, Janes S
    J Immunol, 2015;194(7):3463-74.
  10. Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR.
    Liu Y, Zhang L, Wang C, Roy S, Shen J
    J Biol Chem, 2016;291(4):1553-63.
  11. Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders.
    Niu F, Yao H, Zhang W, Sutliff R, Buch S
    J Neurosci, 2014;34(35):11812-25.
  12. The role of microglial P2X7: modulation of cell death and cytokine release
    Y He, N Taylor, L Fourgeaud, A Bhattachar
    J Neuroinflammation, 2017;14(1):135.
  13. BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm, Bombyx mori
    Z Shen, Y Chen, L Hong, Z Cui, H Yang, X He, Y Shi, L Shi, F Han, N Zhou
    J. Biol. Chem., 2017;0(0):.
  14. The homozygous CX3CR1-M280 mutation impairs human monocyte survival
    AL Collar, M Swamydas, M O'Hayre, MS Sajib, KW Hoffman, SP Singh, A Mourad, MD Johnson, EM Ferre, JM Farber, JK Lim, CM Mikelis, JS Gutkind, MS Lionakis
    JCI Insight, 2018;3(3):.
  15. Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium.
    Lowry J, Brovkovych V, Zhang Y, Skidgel R
    J Biol Chem, 2013;288(6):4174-93.
  16. N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity.
    Sun L, Gu L, Wang S
    PLoS ONE, 2012;7(3):e32503.
  17. Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity.
    Moidunny S, Vinet J
    J Neuroinflammation, 2012;9(1):198.
  18. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
    Carmon K, Gong X, Yi J, Thomas A, Liu Q
    Proc Natl Acad Sci U S A, 2014;111(13):E1221-9.
  19. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
    Breshears L, Schlievert P, Peterson M
    J Biol Chem, 2012;287(39):32578-87.
  20. Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK.
    Dang D, Shin E, Nam Y, Ryoo S, Jeong J, Jang C, Nabeshima T, Hong J, Kim H
    J Neuroinflammation, 2016;13(1):12.
  21. Heat shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK Mitogen Activated Protein Kinase (MAPK) mechanism in mouse brain
    W Lei, N Mullen, S McCarthy, C Brann, P Richard, J Cormier, K Edwards, EJ Bilsky, JM Streicher
    J. Biol. Chem., 2017;0(0):.
  22. Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma
    A Po, M Silvano, E Miele, C Capalbo, A Eramo, V Salvati, M Todaro, ZM Besharat, G Catanzaro, D Cucchi, S Coni, L Di Marcotu, G Canettieri, A Vacca, G Stassi, E De Smaele, M Tartaglia, I Screpanti, R De Maria, E Ferretti
    Oncogene, 2017;0(0):.
  23. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta.
    Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K
    Proc Natl Acad Sci U S A, 2014;111(21):E2229-36.
  24. EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture
    BR Huang, TS Chen, DT Bau, IC Chuang, CF Tsai, PC Chang, DY Lu
    Sci Rep, 2017;7(1):8578.
  25. The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1? expression
    JM Hum, EL Clinkenbea, C Ip, TA Cass, M Allen, KE White
    Bone Rep, 2017;6(0):38-43.
  26. Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.

    Cell Signal, 2012;10(1):19.
  27. Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo
    IN Baranova, ACP Souza, AV Bocharov, TG Vishnyakov, X Hu, BL Vaisman, MJ Amar, Z Chen, AT Remaley, AP Patterson, PST Yuen, RA Star, TL Eggerman
    PLoS ONE, 2017;12(4):e0175824.
  28. Induction of senescence in primary glioblastoma cells by serum and TGF?
    R Kumar, A Gont, TJ Perkins, JEL Hanson, IAJ Lorimer
    Sci Rep, 2017;7(1):2156.
  29. Ginsenoside-Rb2 inhibits dexamethasone-induced apoptosis through promotion of GPR120 induction in bone marrow-derived mesenchymal stem cells.
    Gao B, Huang Q, Jie Q, Zhang H, Wang L, Guo Y, Sun Z, Wei B, Han Y, Liu J, Yang L, Luo Z
    Stem Cells Dev, 2015;24(6):781-90.
  30. Protein kinase C regulates human pluripotent stem cell self-renewal.
    Kinehara et al.
    PLoS One, 2013;8:e54122
  31. Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    Davies et al.
    Biochem.J., 2000;351:95
  32. Identification of a novel inhibitor of mitogen-activated protein kinase kinase.
    Favata et al.
    J.Biol.Chem., 1998;273:18623
  33. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
    Duncia et al.
    Bioorg.Med.Chem.Lett., 1998;8:2839
  34. Intravenous administraton of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia.
    Namura et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:11569
  35. The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients
    K Furue, T Ito, Y Tanaka, A Hashimoto-, M Takemura, M Murata, M Kido-Nakah, G Tsuji, T Nakahara, M Furue
    Int J Mol Sci, 2020;21(2):.
  36. Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes
    K Furue, T Ito, G Tsuji, T Nakahara, M Furue
    J. Dermatol. Sci., 2020;0(0):.
  37. Increased expression of LCN2 formed a positive feedback loop with activation of the ERK pathway in human kidney cells during kidney stone formation
    Z Hui, Z Jiang, D Qiao, Z Bo, K Qiyuan, B Shaohua, Y Wenbing, L Wei, L Cheng, L Shuangning, L Zhengyi, L Yingyi
    Scientific Reports, 2020;10(1):21287.

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Citations for U0126

The citations listed below are publications that use Tocris products. Selected citations for U0126 include:

131 Citations: Showing 1 - 10

  1. Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
    Authors: Li Et al.
    Cell Rep  2021;36:109411
  2. Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1.
    Authors: Ernst Et al.
    Blood Cancer J  2019;9:6
  3. Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway.
    Authors: Szybowska Et al.
    Cells  2019;8:518
  4. Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring.
    Authors: Cagnetta Et al.
    Mol Cell  2019;73:474
  5. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases.
    Authors: Suo Et al.
    Glia  2019;67:1320
  6. Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5.
    Authors: Zhen Et al.
    Biomol Ther (Seoul)  2019;27:395
  7. Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis.
    Authors: Devocelle Et al.
    Int J Cell Biol  2019;2019:9151394
  8. Neural control of body-plan axis in regenerating planaria.
    Authors: Pietak Et al.
    PLoS Comput Biol  2019;15:e1006904
  9. Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11.
    Authors: Domin Et al.
    ACS Chem Neurosi  2019;10:3454
  10. Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complex.
    Authors: Zhang Et al.
    Exp Mol Med  2018;50:e439
  11. The homozygous CX3CR1-M280 mutation impairs human monocyte survival.
    Authors: Collar Et al.
    JCI Insight  2018;3:e95417
  12. Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis.
    Authors: Andersson Et al.
    JCI Insight  2018;3:e122375
  13. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
    Authors: Noskovičová Et al.
    Am J Physiol Lung Cell Mol Physiol  2018;314:L695
  14. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.
    Authors: Kim Et al.
    Cell Rep  2018;25:2148
  15. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.
    Authors: Li Et al.
    Endocrinology  2018;159:285
  16. Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells.
    Authors: Lin Et al.
    Cancer Manag Res  2018;10:4237
  17. Epidermal Growth Factor Receptor Signaling Enhances the Proinflammatory Effects of Staphylococcus aureus Gamma-Toxin on the Mucosa.
    Authors: Gillman Et al.
    Toxins (Basel)  2017;9:202
  18. TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells.
    Authors: Wu
    Arch Biochem Biophys  2017;622:26
  19. Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration.
    Authors: Wan and Goldman
    Cell Rep  2017;19(4):849
  20. Corticotrigeminal Projections from the Insular Cortex to the Trigeminal Caudal Subnucleus Regulate Orofacial Pain after Nerve Injury via Extracellular Signal-Regulated Kinase Activation in Insular Cortex Neurons.
    Authors: Wang Et al.
    Front Cell Neurosci  2016;9:493
  21. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
    Authors: Yang Et al.
    Nat Commun  2016;7:11385
  22. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
    Authors: Lee Et al.
    Cardiorenal Med  2016;7:11322
  23. Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.
    Authors: Zhang Et al.
    Cancer Lett.  2016;371:107
  24. Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.
    Authors: Guo Et al.
    J Neurosci  2016;36:2131
  25. AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons.
    Authors: Tuvikene Et al.
    J Neurosci  2016;36:1290
  26. Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of metha. in the striatum of mice via inhibition of p47phox activation by ERK.
    Authors: Dang Et al.
    Korean J Physiol Pharmacol  2016;13:12
  27. Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment.
    Authors: Liu Et al.
    Mol Cancer  2015;5:79
  28. A temporal shift in the circuits mediating retrieval of fear memory.
    Authors: Do-Monte Et al.
    J Neuroinflammation  2015;519:460
  29. Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma.
    Authors: Koerber Et al.
    Int J Cancer  2015;4:21
  30. MAPK signaling downstream to TLR4 contributes to PacT.-induced peripheral neuropathy.
    Authors: Li Et al.
    Brain Behav.Immun.  2015;49:255
  31. Type 1 Ins-Like Growth Factor Receptor/Ins Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.
    Authors: Meyer Et al.
    Mol Cell Biol  2015;35:2991
  32. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity.
    Authors: Briz Et al.
    Exp Hematol Oncol  2015;35:2269
  33. IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer.
    Authors: Zhao Et al.
    Nature  2015;34:1596
  34. Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis.
    Authors: Saliba Et al.
    J Am Soc Nephrol  2015;26:1855
  35. P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance.
    Authors: Tang Et al.
    J Immunol  2015;195:1191
  36. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Authors: Lourenco Et al.
    J Immunol  2015;194:3463
  37. Receptor protein tyrosine phosphatase β/ζ is a functional binding partner for vascular endothelial growth factor.
    Authors: Koutsioumpa Et al.
    J Neurosci  2015;14:19
  38. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    J Neurosci  2015;136:E219
  39. Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.
    Authors: Sovadinova Et al.
    Oncogene  2015;10:e0124454
  40. Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.
    Authors: Grell Et al.
    PLoS One  2014;9:e113624
  41. hesperidin induces paraptosis like cell death in hepatoblastoma, HepG2 Cells: involvement of ERK1/2 MAPK [corrected].
    Authors: Yumnam Et al.
    PLoS One  2014;9:e101321
  42. Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration.
    Authors: Wan Et al.
    Neuroscience  2014;9:285
  43. Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex.
    Authors: Christianson Et al.
    Front Behav Neurosci  2014;8:348
  44. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching.
    Authors: Guemez-Gamboa Et al.
    Neuron  2014;82:1004
  45. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
    Authors: Alpár Et al.
    Cell Rep  2014;5:4421
  46. Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo.
    Authors: Wan Et al.
    FASEB J  2014;28:3456
  47. Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.
    Authors: Emery Et al.
    J Biol Chem  2014;289:10126
  48. ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamox. resistance in ER+ breast cancer.
    Authors: Heckler Et al.
    FEBS J  2014;281:2431
  49. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    J Neuroinflammation  2014;171:5417
  50. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer  2014;14:113
  51. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
    Authors: Schubert Et al.
    Acta Neuropathol  2014;128:835
  52. MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
    Authors: Grzmil Et al.
    J Clin Invest  2014;124:742
  53. Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice.
    Authors: Nemoto Et al.
    Mol Pain  2013;9:38
  54. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
    Authors: Voon Et al.
    PLoS One  2013;8:e70427
  55. Polycyclic aromatic hydrocarbon-induced signaling events relevant to inflammation and tumorigenesis in lung cells are dependent on molecular structure.
    Authors: Osgood Et al.
    PLoS One  2013;8:e65150
  56. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer.
    Authors: Lucchetti Et al.
    PLoS One  2013;8:e55355
  57. Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.
    Authors: Li Et al.
    Invest Ophthalmol Vis Sci  2013;54:2872
  58. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.
    Authors: Berdichevsky Et al.
    J Neurosci  2013;33:9056
  59. MAPK establishes a molecular context that defines effective training patterns for long-term memory formation.
    Authors: Philips Et al.
    J Neurosci  2013;33:7565
  60. Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation.
    Authors: Ripple Et al.
    J Biol Chem  2013;288:2933
  61. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
    Authors: Korb Et al.
    Nat Neurosci  2013;16:874
  62. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
    Authors: Melemedjian Et al.
    Pain  2013;154:1080
  63. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
    Authors: Morse Et al.
    BMC Pharmacol Toxicol  2013;14:17
  64. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection.
    Authors: Jensen Et al.
    J Neurosci  2013;13:67
  65. DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;125:193
  66. Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes.
    Authors: Meyer Et al.
    J Pharmacol Exp Ther  2013;11:6
  67. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
    Authors: Gangoiti Et al.
    Biochimie  2012;94:597
  68. Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6).
    Authors: Yan Et al.
    Mol Pain  2012;8:6
  69. Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the IF.-JAK-STAT pathway.
    Authors: Zhang Et al.
    J Virol  2012;86:1544
  70. Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways.
    Authors: Li Et al.
    J Virol  2012;86:12531
  71. Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways.
    Authors: Lee Et al.
    PLoS One  2012;7:e50624
  72. Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT.
    Authors: Chen Et al.
    Int J Mol Med  2012;30:1021
  73. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
    Authors: Breshears Et al.
    J Biol Chem  2012;287:32578
  74. Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
    Authors: Arora Et al.
    Cell Commun Signal  2012;10:19
  75. Phenotype-based high-content chemical library screening identifies STAT as inhibitors of in vivo lymphangiogenesis.
    Authors: Schulz Et al.
    Proc Natl Acad Sci U S A  2012;109:E2665
  76. Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.
    Authors: Ye Et al.
    Proc Natl Acad Sci U S A  2012;109:18162
  77. Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion.
    Authors: Hodges Et al.
    Exp Eye Res  2012;103:99
  78. Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF.
    Authors: Dohgu Et al.
    Br J Pharmacol  2011;8:167
  79. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide.
    Authors: Kovac Et al.
    J Neurosci  2011;8:139
  80. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.
    Authors: Melemedjian Et al.
    Mol Pain  2011;7:70
  81. A screen for regulators of survival of motor neuron protein levels.
    Authors: Makhortova Et al.
    Nat Chem Biol  2011;7:544
  82. Interleukin-2 Functions in Anaplastic Large Cell Lymphoma Cells through Augmentation of Extracellular Signal-Regulated Kinases 1/2 Activation.
    Authors: Ito Et al.
    Int J Biomed Sci  2011;7:181
  83. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  84. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097
  85. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
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By Anonymous on 07/17/2017

To block the gpcr signaling and determine the pathway of an orphan receptor

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