U0124
Chemical Name: Bis[amino(methylthio)methylene]butanedinitrile
Biological Activity
U0124 is an inactive analog of U0126 (Cat. No. 1144). Does not inhibit MEK at concentrations up to 100 μM. Used as a negative control.Active Analog also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium.
Lowry J, Brovkovych V, Zhang Y, Skidgel R
J Biol Chem, 2013;288(6):4174-93. -
Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway.
Fitzgerald
J.Physiol., 2000;527:433 -
Identification of a novel inhibitor of mitogen-activated protein kinase kinase.
Favata et al.
J.Biol.Chem., 1998;273:18623 -
Concerted transcriptional activation of the low density lipoprotein receptor gene by Ins and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated pro
Sekar et al.
Endocrinology, 2001;142:2921
Product Datasheets
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Citations for U0124
The citations listed below are publications that use Tocris products. Selected citations for U0124 include:
9 Citations: Showing 1 - 9
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MAPK establishes a molecular context that defines effective training patterns for long-term memory formation.
Authors: Philips Et al.
Nutr Metab Cardiovasc Dis 2013;33:7565
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mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
Authors: Melemedjian Et al.
Pain 2013;154:1080
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Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.
Authors: Ye Et al.
Proc Natl Acad Sci U S A 2012;109:18162
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Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.
Authors: Melemedjian Et al.
Mol Pain 2011;7:70
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Influence of chylomicron remnants on human monocyte activation in vitro.
Authors: Bentley Et al.
Skelet Muscle 2011;21:871
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Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
Authors: Kolber Et al.
J Neurosci 2010;30:8203
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Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci 2010;30:6080
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Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway.
Authors: Chen-Roetling Et al.
Neuropharmacology 2009;56:922
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Oestrogen increases nociception through ERK activation in the trigeminal ganglion: evidence for a peripheral mechanism of allodynia.
Authors: Liverman Et al.
Cephalalgia 2009;29:520
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