Cripto: Products

Cripto, also known as TDGF-1 (Teratocarcinoma-Derived Growth Factor), is the founding member of the Epidermal Growth Factor-Cripto-1/FRL1/Cryptic Protein family of signaling proteins that function in cancer and various developmental processes. Mouse Cripto shares 66% and 34% amino acid identity with human Cripto and zebrafish one-eyed pinhead (OEP), respectively. Genetic evidence from mice and zebrafish points to a role for Cripto as an essential cofactor in Nodal signaling.