EphB3: Products
EphB3, also known as Cek10, Tyro6, Sek4, Hek2, and Mdk5, is a widely expressed receptor tyrosine kinase that binds to Ephrin B ligands and exerts important functions in vascular, nervous system, thymocyte, and palate development.
It directs embyronic neuronal axon pathfinding, and its upregulation on local macrophages following neuronal injury promotes the growth of regenerating axons. EphB3 inhibits colorectal carcinogenesis and invasion but can promote tumor progression in non-small cell lung cancer.
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