GPR39: Products
GPR39 is a seven transmembrane G protein coupled glycoprotein that is a member of the ghrelin receptor family. GPR39 is expressed in the stomach, small intestine and areas of the brain including the hypothalamus; its ligand is the ghrelin-associated peptide, obestatin. Obestatin decelerates gastric emptying and decreases intestinal contractility in mice, couteracting the effects of ghrelin. GPR39 has not been shown to be internalized upon ligand binding.
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