Mind Bomb 2/MIB2: Products

Mind Bomb 2/MIB2, also called skeletrophin, is a widely expressed, 1013 amino acid cytoplasmic phosphoprotein that is an E3 ubiquitin ligase for Notch ligands such as Jagged-2. It contains two MIB/HERC2 domains surrounding a ZZ-type zinc finger, an ankyrin repeat domain, and two RING-type zinc fingers that have E3 ubiquitin ligase activity. MIB-2 has been detected as a 70 kDa form in skeletal muscle, binds actin, and is downregulated in malignant melanoma.