"14-3-3" has 9 results in Resources.

R&D Systems offers quality products for the study of pSer- and pThr-binding proteins. 14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric proteins present in high abundance in all eukaryotic cells. 14-3-3 proteins act as key regulators of intracellular signal transduction through their ability to bind specific motifs containing phosphorylated serine or threonine...

Akt Pathway-dependent Regulation of Autophagy Autophagy, which degrades cytoplasmic components to generate recycled nutrients, can have either an oncogenic or tumor suppressive role in cancer. 1 In contrast, Akt is known to promote cellular transformation and tumorigenesis, and dysregulated Akt activity is observed in many cancer types.2 The oncogenic potential of dysregulated Akt is often...

Featured Literature Caspase Activation & Apoptosis Poster View Poster Featured Product TACS Annexin V-FITC Apoptosis Detection Kit View Products   Overview of the Extrinsic and Intrinsic Pathways of Caspase Activation Caspases are a family of aspartate-specific, cysteine proteases that serve as the primary mediators of apoptosis. All caspases...

Extrinsic & Intrinsic Pathways of Caspase Activation Caspases are a family of aspartate-specific, cysteine proteases that serve as the primary mediators of apoptosis. Mammalian caspases can be subdivided into three functional groups, apoptotic initiator caspases (Caspase-2, -8, -9, -10), apoptotic effector caspases (Caspase-3, -6, -7), and caspases involved in inflammatory cytokine processing...

The intrinsic pathway of caspase activation can be initiated in response to DNA damage, growth factor withdrawal, loss of contact with the extracellular matrix, or glucocorticoids. These conditions promote signaling pathways that lead to a loss in the integrity of the mitochondrial membrane and caspase activation. The Bcl-2 family comprises a group of structurally related proteins that play a...

The concept that accumulation of unwanted cells is due to uncontrolled cell proliferation has been amended. Cells also accumulate when proliferation rates are normal but death rates are lower. The realization that cell death is a normal process in development and cellular homeostasis has opened a completely new avenue for exploration of the causes and treatments of...

First printed in R&D Systems' 2000 Catalog. Overview A healthy organism is an exquisitely integrated collection of differentiated cells, which maintain a balance between life and death. Some cells are irreplaceable, some cells complete their functions and are then sacrificed, and some cells live a finite lifetime to be replaced by yet another generation. A failure of cells to fulfill their...

First Printed in R&D Systems 2003 Catalog Contents Introduction Cell Cycle Checkpoints G1 Checkpoint S-phase Checkpoint G2 Checkpoint DNA Repair Pathways References Introduction The maintenance of genome integrity and fidelity is essential for the proper function and survival of all organisms. This task is particularly daunting due to constant assault on the DNA by genotoxic...

Its Role in Growth Factor Signaling and Cancer Contents Upstream from ERK The Core Module Downstream from ERK Conclusions References Growth factors, through receptor tyrosine kinases, recruit a large network of signaling proteins to execute their cellular programs. The first of these networks to be discovered was the Ras-Raf-ERK signal transduction cascade, defined by Extracellular...