"BACE" has 9 results in Resources.

Figure 1. Amyloid plaque production. A beta-secretase, BACE, cleaves the precursor protein (APP) and gamma-secretase cleaves the membrane-bound C99 fragment to release A beta from the membrane. beta-secretases have been implicated in the formation of the 4 kDa amyloid beta-peptide (A beta) found within amyloid plaques of Alzheimer’s disease. A beta is formed by the cleavage...

APP Cleavage & A-beta degradation Neuroscience research suggests a delicate balance between physiological and pathological events in the brain. Healthy neurons predominantly process beta-amyloid precursor protein (APP) via non-amyloidogenic alpha-secretase-driven cleavage. The majority of beta-amyloid peptide (A-beta) generated is rapidly degraded by a range of enzymes expressed in neurons and...

Sheddases cleave membrane proteins at the cell surface, releasing soluble ectodomains with altered location and function. Some sheddases are membrane proteins themselves that belong to metalloprotease (ADAM and MMP) or aspartic protease (BACE) families. Their activity can be constitutive or regulated through various processes such as PKC activation, Ca2+ influx, and lipid rafts.1-3 A single...

Sporadic, or late-onset, AD affects approximately 10% of the population over the age of sixty-five, making it the most prevalent neurodegenerative disorder. This devastating condition is characterized by progressive cognitive impairment and neurodegeneration, commencing in the hippocampus and cortex. Neuropathological hallmarks of AD include neuronal loss in the presence of neurofibrillary...

Analyte DuoSet® and DuoSet IC ELISA Development Systems Quantikine® ELISA Kits ACE DY929 DACE00 ADAM8 DY1031   ADAM9 DY939   ADAM10     ALCAM/CD166 DY656   Amphiregulin DY262   APP (pan) DY850   BACE-1 DY931   BCAM/CD239 DY148   C1q...

Human sReceptor Array Kit Hematopoietic Panel Ordering Information Introduction R&D Systems Human Soluble Receptor Array Kit Hematopoietic Panel (Catalog # ARY011) is a rapid, sensitive, and economical tool used to simultaneously detect the relative levels of 105 different soluble receptors expressed and released by hematopoietic cells in a single sample. No specialized equipment is...

Human sReceptor Array Kit Non-Hematopoietic Panel Ordering Information Introduction R&D Systems Human Soluble Receptor Array Kit Non-Hematopoietic Panel (Catalog # ARY012) is a rapid, sensitive, and economical tool used to simultaneously detect the relative levels of 119 different soluble receptors expressed and released by non-hematopoietic cells in a single sample. No specialized...

Figure. 1. Structure of PS1 and chemical inhibitors. PS1 plays a role in gamma-secretase cleavage of APP. BACE/beta-secretase (blue) cleaves APP after Met671, creating a membrane-retained C-terminal fragment. This fragment can then be cleaved by gamma-secretase (purple) within the hydrophobic transmembrane domain to release A beta. [Inset: Chemical structures of the...

First printed in R&D Systems' 2001 Catalog. Contents Introduction Amyloid Precusor Protein (APP) Presenilin-1 (PS1) and Presenilin-2 (PS2) Apolipoprotein E (ApoE) Cytokines associated with AD References Introduction Alzheimer's Disease (AD) is a neurodegenerative disease of the central nervous system associated with progressive memory loss resulting in dementia. Two pathological...