"Fc" has 110 results in Resources.

The Fc receptors are transmembrane proteins typically classified based on the class of antibody they recognize. For instance, Fc gamma receptors bind IgG, Fc epsilon Receptors bind IgE and FcR alpha binds IgA and IgM. Fc receptors are expressed by a range of immune cell types where they bind the Fc region of antibodies and modulate immune-related functions such as phagocytosis, cytolytic...

The B7 family and other T cell co-stimulatory/co-inhibitory molecules are widely recognized as therapeutic targets for cancer immunotherapy. V-Set and Immunoglobulin domain containing (VSIG) proteins are members of the immunoglobulin protein superfamily and are increasingly recognized as potential immuno-oncology targets. In fact, R&D Systems scientists have identified VSIG3 as the ligand of...

The B7 family and other T cell co-stimulatory/co-inhibitory molecules are widely recognized as therapeutic targets for cancer immunotherapy. Many of these are members of the large immunoglobulin superfamily. V-Set and Immunoglobulin domain containing (VSIG) proteins are members of the immunoglobulin protein superfamily and are increasingly recognized as potential immuno-oncology targets. Perhaps...

SIRPs are paired receptors, with similar extracellular domains but different transmembrane and cytoplasmic regions which result in opposing signals, either activating or inhibitory. The best studied SIRP family member is SIRP alpha. SIRP alpha expression is restricted to myeloid cells while its binding partner CD47 is expressed on T cells. Reagents blocking the SIRP-alpha/CD47 interaction could...

Siglecs (sialic acid-binding immunoglobulin-type lectins) are receptors predominantly located on the surface of hematopoietic cells. Recent publications highlight the important roles Siglecs play in tumor immunosurveillance making them attractive anti-cancer drug targets. Inhibitory receptors Siglec-7 and Siglec-9 are expressed on NK cells and recognize tumor-associated sialosides (1,2). Also,...

J. Wang, B. Manick, G. Wu, R. Hao ABSTRACT Three new B7 family members, B7-H5 (VISTA, Gi24, or Dies1), B7-H6, and B7-H7 (HHLA2) were recently identified, but their functions remain uncertain. We expressed the human B7-H5, B7-H6, and B7-H7 extracellular domain human IgG1 Fc Chimeras in a mammalian cell line and investigated the functions of the purified recombinant B7-H5/Fc, B7-H6/Fc, and...

The B7 family and other T cell co-stimulatory/co-inhibitory molecules are widely recognized as therapeutic targets for regulating the immune response. Butyrophilins are a novel class of co-stimulatory/co-inhibitory molecules that are structurally related to the B7 family and appear to have similar immunomodulatory functions. These parallels suggest that the butyrophilins or their receptors may...

The B7-like proteins play critical immunomodulatory roles and constitute attractive targets for the development of novel immunotherapies. There are a range of related proteins yet to be studied for their effect on the immune system. R&D Systems researchers have screened several proteins from the VSTM family and find many exhibit immunosuppressive activity. V-set and transmembrane domain...

Antibody Isotype Controls A wide selection of species-specific IgG isotype controls conjugated to a variety of labels. Secondary Antibodies We offer a range of secondary antibodies for flow cytometry, immunohistochemistry, and Western blotting. Staining Reagents for Flow Cytometry Flow Cytometry Staining Buffer (1X) (Catalog # FC001) For immunofluorescent staining of single-cell...

The activation state of T cells is dependent upon the integration of signals derived from the T cell receptor (TCR) complex through antigen presentation, and secondary co-stimulatory or co-inhibitory signals delivered by members of the B7 family. For instance, a classical co-stimulatory response is initiated by B7-1 or B7-2 engagement of the T cell receptor CD28. These same ligands may also...