"JNK" has 40 results in Resources.

Oxidative stress activates the MAPK signaling pathway. ERK, JNK, and p38 kinase activation in response to oxidative stress through the production of reactive oxygen species (ROS) can have both prosurvival and proapoptotic effects. ROS-activated PLC-gamma and Src phosphorylate Ras and Raf, both directly and indirectly, which ultimately leads to ERK activation. Activated ERK both positively and...

R&D Systems Proteome Profiler™ MAPK Array Kit may be suitable for use in multiple model systems.   Human Mouse Rat ERK1 x x x ERK2 x x x JNK1 x x x JNK2 x x x JNK3 x NA NA JNK...

Analyte DuoSet® IC ELISA Development System (Total) DuoSet® IC ELISA Development Systems (Phospho) Akt1 (S473) DYC1775 DYC2289C Akt2 (S474) DYC2315   Akt3 (S472)     Akt pan (S473, S474, S472)   DYC887B CREB (S133)   DYC2510 ERK1 (T202/Y204) DYC1940 DYC1825 ERK2...

Human Phospho-MAPK Array Kit Ordering Information Introduction The Human Phospho-Mitogen-activated Protein Kinase (MAPK) Antibody Array (Catalog # ARY002B) is an economical tool used to simultaneously detect the relative phosphorylation of 24 kinases without performing numerous immunoprecipitation and/or Western blots. Kinases are captured by 26 different antibodies spotted in duplicate on...

Analyte Phospho-Specific Antibodies Affinity Purified Polyclonal Antibodies (Total) Monoclonal Antibodies (Total) Labeled Antibodies (Total) Akt1 (S473)   AF1775, AF17751 MAB1775, MAB17752   Akt2 (S474)   AF2315, AF23151 MAB2315   Akt3 (S472)     MAB1463   Akt pan (S473, S474,...

The major output of MAPK signaling downstream of inflammatory cytokines is a proinflammatory response. TNF Receptor (TNFR) activation by TNF superfamily ligands leads to recruitment of TRAF-2, TRAF-3, TRAF-6, and IKK gamma to the TNFR complex. TRAF-2 and TRAF-6 are subsequently auto-polyubiquitinated with Lys63-linked chains in a Ubc13-Uev1a-dependent manner. Ubiquitinated TRAF-2 and TRAF-6...

Multiple proteins are involved in mediating Wnt signaling. The three established Wnt signaling pathways are referred to as the canonical pathway, the planar cell polarity (PCP) pathway, and the Wnt-Ca2+ pathway. Proteins that promote the canonical beta-Catenin-dependent signaling pathway include GSK-3 beta, Casein Kinase 1 (CK1), Dishevelled, beta-Catenin, and co-activators such as Bcl-9 and...

Protein kinases transfer phosphate groups from ATP to serine, threonine, or tyrosine residues on protein peptide substrates, directly affecting the activity and function of the target. Radiolabel studies suggest that approximately 30% of proteins in eukaryotic cells are subject to phosphorylation. Kinase activity, a crucial post-translational modification, regulates a broad range of cellular...

Obesity has increased dramatically in the United States with serious health consequences.1 The metabolic consequences of obesity, often termed metabolic syndrome, include lipotoxicity, inflammation, and insulin resistance, which increase the risk of type II diabetes, atherosclerosis, hypertension, and cardiovascular disease. Obesity-related lipotoxicity is thought to result from overloading the...

Featured Literature Pattern Recognition Receptors and the Innate Immune Response Poster View Poster Featured Products Pattern Recognition Receptors Brochure View Brochure   Overview of Toll-like Receptors Toll-like receptors (TLRs) are a family of transmembrane pattern recognition receptors that detect invading pathogens and initiate the...