"wnt" has 78 results in Resources.

View Wnt SignalingPathways:beta-Catenin-dependentWnt Signaling View Wnt SignalingPathways:beta-Catenin-independentWnt/Ca2+ Signaling andOther Non-canonical WntSignaling Pathways Wnt SignalingPathways:beta-Catenin-independentWnt/PCP Signaling Pathways The molecular name Wnt is derived from Wingless, the Drosophila melanogaster segment-polarity gene, and Integrase-1, the vertebrate homologue. The...

Wnt signaling can be inhibited by several antagonists that bind either to the Wnt ligand itself, or to Wnt receptors. Known antagonists of Wnt signaling include Dickkopf (Dkk) proteins, Wnt Inhibitory Factor-1 (WIF-1), and secreted Frizzled-Related Proteins (sFRPs). The Dkk family of secreted proteins includes Dkk-1-4 and Soggy, a protein with homology to Dkk-3, but not other Dkk family members....

The complexity of Wnt intracellular signaling pathways parallels the complexity observed in the diversity of Wnt receptors. Wnt receptors include the Frizzled family, Low Density Lipoprotein Receptor-related Proteins-5/6 (LRP-5/6), Receptor Tyrosine Kinase-like Orphan Receptor-1/2 (ROR1/2), and related to tyrosine (Y) kinase (Ryk). Frizzled receptors are seven transmembrane G protein-coupled...

Wnts are a large family of secreted glycoproteins that play a central role in embryonic development, differentiation, cell motility, cell proliferation, and adult tissue homeostasis. Wnt signaling can activate beta-Catenin-dependent TCF/LEF transcription and at least two well-characterized beta-Catenin-independent pathways, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. The...

In this brochure you will find a catalog of our proteins, antibodies, and ELISAs for Wnt Research. Some of the topics and tools that you can expect to find inside are: Detailed Wnt signaling pathways Largest selection of Wnt Ligands New tools to study Wnt signaling regulators R-spondin 1 products Products for Wnt Research (3 MB)  

Multiple proteins are involved in mediating Wnt signaling. The three established Wnt signaling pathways are referred to as the canonical pathway, the planar cell polarity (PCP) pathway, and the Wnt-Ca2+ pathway. Proteins that promote the canonical beta-Catenin-dependent signaling pathway include GSK-3 beta, Casein Kinase 1 (CK1), Dishevelled, beta-Catenin, and co-activators such as Bcl-9 and...

Wnt ligands are a large family of secreted glycoproteins that are cysteine-rich and highly hydrophobic. Wnts are produced as precursor proteins that contain a short N-terminal signal sequence and a mature segment that varies in length from approximately 320 to 400 amino acids. In vertebrates, there are 19 different Wnt proteins whose expression is spatially and temporally regulated during...

First Published in R&D Systems' 2005 Catalog Contents Membrane-bound Wnt Receptors Extracellular Wnt-Pathway Mediators and Receptors References Wnt receptors and signaling pathways may constitute the most complex relationship between extracellular ligands and receptors identified to date. This mini-review focuses on the structures and relationships of the Wnt receptors, both with...

Given that Wnt signaling underlies a diverse range of complex biological functions, modulators of Wnt signaling are of great interest. A number of proteins can either enhance or inhibit Wnt signaling, including Glypicans, R-Spondin proteins, Kremen-1, Kremen-2, Norrin, Sclerostin (SOST), and MESDC2. Glypicans are a family of six heparan sulfate proteoglycans that are anchored to the plasma...

The Wnt signaling pathway contributes to many developmental decisions in a variety of cell types and animal models. Wnt signaling is involved in cell fate determination, cell polarity, tissue patterning, control of cell proliferation, and development of neoplasia.1,2 Wnt proteins are secreted glycoproteins with a conserved pattern of 23-24 cysteine residues. There are 19 Wnt family members in the...