Monitoring Cell and Gene Therapy Efficacy and Toxicity
Bring your research to the clinic with Bio-Techne’s comprehensive solutions for Cell and Gene Therapy Manufacturing. To view our complete solutions for Cell and Gene Therapy including GMP-grade reagents and 21 CFR Part 11-compliant analytical instrumentation, visit bio-techne.com.
Stem Cell Engraftment After Infusion
Keep a close eye on how your cell or gene therapy performs in vivo. Track cell homing to the target tissue, cell persistence in the target tissue, and continued cell function.
| RNAscope™ in situ Hybridization Assays (at acd.com) Single-cell RNA expression analysis to localize your cell therapy in the target tissue |
| Epitope Tag Antibodies For detection of tagged molecules in your genetic construct |
| Monitoring T Cell Exhaustion Reagents and assays to confirm that your cells don’t become over-activated in vivo |
| Reagents and Assays for Exosome Research (at novusbio.com) To monitor microvesicles released by your cell or gene therapy |
| Suicide Switch Triggering and Monitoring for Cell Therapy Inactivation Apoptosis Inducer Compounds (at tocris.com) Apoptosis Detection Kits and Reagents |
Systemic Host Response
Analyze how the host responds to your cell therapy. Our multiple assay platforms will give you flexibility to monitor circulating biomarkers of cytokine release syndrome, tissue and organ damage, and immunogenicity.
| Proteome Profiler™ Antibody Arrays No specialized equipment required; affordable screening tool for discovery-level research |
| DuoSet™ ELISA Development Reagents Flexible and economical for discovery-level research; over 1,000 available |
| Quantikine™ ELISA Kits Industry gold standard ELISAs as you transition to clinical-level research; over 450 available |
| Luminex™ Assays and Luminex High Performance Assays Quantitative multiplex for up to 100 analytes and for translational medicine applications |
| Simple Plex™ Assays (at proteinsimple.com) Automated, parallel immunoassays for translational medicine applications; results in < 1 hour |
| Simple Western™ Assays (at proteinsimple.com) Automated, 3-hour capillary-based immunoassays and size assays for translational medicine applications |
| Antibodies for Disease Biomarkers (at biospacific.com) |
Host Tissue Response to Cell Therapy
Evaluate the efficacy of your cell therapy in the tissue you’re targeting. Determine if your treatment is inducing tumor regression, tissue regeneration, angiogenesis, immune cell infiltration, apoptosis, fibrosis, or other relevant measures.
| Proteome Profiler™ Angiogenesis Array Kits Simultaneous blot-based detection of >50 proteins in human or mouse |
| Luminex® Angiogenesis Panel Highly validated, accurate, and precise multianalyte profiling |
| Simple Plex™ Assays (at proteinsimple.com) Automated quantitation of cytokine secretion profiles in <1 hour |
| Angiogenesis Assays |
| IHC Antibodies for Vascular Endothelium |
Custom Services
Our Custom Services team will work closely with you and expert R&D Systems scientists to develop effective methods for monitoring the host response to your cell or gene therapy. We can help you adopt a robust host monitoring system that will be valuable as you move toward and into clinical testing.
Learn more about Custom Services for Cell Therapy.
| RNAscope™ in situ Hybridization video (at acdbio.com) | |
| Simple Plex™ with Ella video (at proteinsimple.com) | |
| Simple Western™ with Jess video (at proteinsimple.com) | |
| Proteome Profiler™ Antibody Arrays video | |
| Immunoassay Workflow Solutions | |
| ExosomeDx Biomarker Discovery (at ExosomeDx.com) | |
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Immune Cell Therapy Workflow Wall Poster
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