Hematopoietic Stem Cell Differentiation Pathways & Lineage-specific Markers
Click on a cell type below to view a subset of molecules used as markers for the identification of that cell type.
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factors
inhibitors
inhibitors
Stem Cells
Stem Cells
Progenitor Cells
Progenitor Cells
Cells
Cells
Expansion Kit
Expansion Kit
Ligand
Ligand
Cells
Cells
Progenitor Cells
Progenitor Cells
Progenitor Cells
Progenitor Cells
derived DC
Differentiation Kit
derived DC
Differentiation Kit
Dendritic Cells
Dendritic Cells
Progenitor Cells
Progenitor Cells
Overview of Hematopoietic Stem Cells & Lineage-specific Markers
Hematopoietic stem cells (HSCs) are multipotent, self-renewing progenitor cells from which all differentiated blood cell types arise during the process of hematopoiesis. These cells include lymphocytes, granulocytes, and macrophages of the immune system as well as circulating erythrocytes and platelets. Classically, HSCs are thought to differentiate into two lineage-restricted, lymphoid and myelo-erythroid, oligopotent progenitor cells. An alternative, “myeloid-based” model for blood lineage development from HSCs describes a novel intermediary, a common myelo-lymphoid progenitor cell, which has the capacity to generate progeny from both lineages. The mechanisms controlling HSC self-renewal and differentiation are thought to be influenced by a diverse set of cytokines, chemokines, receptors, and intracellular signaling molecules. Differentiation of HSCs is regulated, in part, by growth factors and cytokines including colony-stimulating factors (CSFs) and interleukins (ILs) that activate intracellular signaling pathways. The factors depicted below are known to influence HSC multipotency, proliferation, and lineage commitment. HSCs and their differentiated progeny can be identified by the expression of specific cell surface lineage markers such as cluster of differentiation (CD) proteins and cytokine receptors.
To learn more, please visit our Hematopoietic Stem Cell Molecules Research Area.
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