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1-Deazaadenosine

Catalog #: 4488
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4488/10
1-Deazaadenosine | CAS No. 14432-09-8 | Deaminase Inhibitors
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Description: Adenosine deaminase inhibitor

Chemical Name: 3-β-D-Ribofuranosyl-3H-imidazo[4,5-b]pyridin-7-amine

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

1-Deazaadenosine is an inhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.

Technical Data

M.Wt:
266.25
Formula:
C11H14N4O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
14432-09-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues.
    Cristalli et al.
    Drug Dev.Res., 1993;28:253
  2. Improved synthesis and antitumor activity of 1-deazaadenosine.
    Cristalli et al.
    J.Med.Chem., 1987;30:1686

Product Datasheets

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Citations for 1-Deazaadenosine

The citations listed below are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:

2 Citations: Showing 1 - 2

  1. Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases.
    Authors: Alexey Et al.
    EMBO J  2022;41:e111608
  2. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.
    Authors: Li Et al.
    Anticancer Res  2015;3:e00121

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