2-[1-(4-Piperonyl)piperazinyl]benzothiazole
![2-[1-(4-Piperonyl)piperazinyl]benzothiazole | CAS No. 155106-73-3 | 5-HT4 Receptor Agonists](https://resources.rndsystems.com/images/datasheets/structures/2-1-4-piperonylpiperazinylbenzothiazole_0736.png "2-[1-(4-Piperonyl)piperazinyl]benzothiazole | CAS No. 155106-73-3 | 5-HT4 Receptor Agonists")
Biological Activity
5-HT4 receptor agonist with moderate activity as a 5-HT3 antagonist. Has no affinity at 5-HT1 or dopamine D2 receptors. Potential gastrokinetic agent.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Synthesis of 2-piperazinybenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.
Monge et al.
J.Med.Chem., 1994;37:1320
Product Datasheets
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Citation for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole
The citations listed below are publications that use Tocris products. Selected citations for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole include:
1 Citation: Showing 1 - 1
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Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells.
Authors: Gill Et al.
Am J Physiol Gastrointest Liver Physiol 2008;295:G700
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