2-BFI hydrochloride
Chemical Name: 2-(2-Benzofuranyl)-2-imidazoline hydrochloride
Biological Activity
2-BFI hydrochloride is a high affinity I2 ligand (Ki = 9.8 nM). Putative I2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes.
Alemany et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:39 -
Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway.
MacInnes and Dut
Br.J.Pharmacol., 2004;143:952 -
Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Sanchez-Blasquez et al.
Br.J.Pharmacol., 2000;130:146
Product Datasheets
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Citations for 2-BFI hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 2-BFI hydrochloride include:
2 Citations: Showing 1 - 2
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On the formation and nature of the imidazoline I2 binding site on human monoamine oxidase-B.
Authors: McDonald Et al.
Pharmacol Res 2020;62:475
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Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
Authors: Kim Et al.
Brain Res 2011;1384:110
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