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2-Chloro-N6-cyclopentyladenosine

Catalog #: 1705
11 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1705/10
1705/50
2-Chloro-N6-cyclopentyladenosine | CAS No. 37739-05-2 | Adenosine A1 Receptor Agonists
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Description: Potent and selective A1 agonist
Alternative Names: CCPA

Chemical Name: 2-Chloro-N-cyclopentyladenosine

Purity: ≥98%

Product Details
Citations (11)
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Biological Activity

2-Chloro-N6-cyclopentyladenosine is a potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
369.81
Formula:
C15H20ClN5O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
37739-05-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Extracellular adenosine controls NKT-cell-dependent hepatitis induction.
    Subramanian M, Kini R, Madasu M, Ohta A, Nowak M, Exley M, Sitkovsky M, Ohta A
    Eur J Immunol, 2014;44(4):1119-29.
  2. Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
    Concas et al.
    J.Pharmacol.Exp.Ther., 1993;267:844
  3. Adenosine receptors and their ligands.
    Klot
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  4. Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.
    Monopoli et al.
    Arzneimittelforschung, 1994;44:1305
  5. 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.
    Lohse et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1988;337:687

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Citations for 2-Chloro-N6-cyclopentyladenosine

The citations listed below are publications that use Tocris products. Selected citations for 2-Chloro-N6-cyclopentyladenosine include:

11 Citations: Showing 1 - 10

  1. Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats.
    Authors: Fabera Et al.
    Front Pharmacol  2019;10:656
  2. Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts.
    Authors: Goldman Et al.
    BMC Pharmacol Toxicol  2013;53:297
  3. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
    Authors: Loram Et al.
    Brain Behav Immun  2013;33:112
  4. Opiate-induced changes in brain adenosine levels and narcotic drug responses.
    Authors: Wu Et al.
    J Neurosci  2013;228:235
  5. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
    Authors: Park Et al.
    Kidney Int  2012;82:878
  6. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Neuroscience  2012;32:14489
  7. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
    Authors: Crawford Et al.
    Cell Calcium  2012;32:13100
  8. Adenosine receptor signaling modulates permeability of the blood-brain barrier.
    Authors: Carman Et al.
    J Neurosci  2011;31:13272
  9. Adenosine-induced activation of esophageal nociceptors.
    Authors: Ru Et al.
    Am J Physiol Gastrointest Liver Physiol  2011;300:G485
  10. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
    Authors: Keene Et al.
    Biochem Pharmacol  2010;80:188

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