2-Iodomelatonin
Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
Purity: ≥98%
Biological Activity
2-Iodomelatonin is a potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors.
Browning et al.
Br.J.Pharmacol., 2000;129:877 -
Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina.
Dubocovich and Takahashi
Proc.Natl.Acad.Sci.U.S.A., 1987;84:3916 -
Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain.
Suiciak et al.
J.Neurosci., 1991;11:2855
Product Datasheets
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Citations for 2-Iodomelatonin
The citations listed below are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:
5 Citations: Showing 1 - 5
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A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
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Structural basis of ligand recognition at the human MT1 melatonin receptor
Authors: Stauch Et al.
Nature 2019;569:284
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Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Authors: Hou Et al.
Front Cell Neurosci 2017;11:98
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Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.
Authors: Calamini Et al.
Biochem J 2008;413:81
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Identification of the melatonin-binding site MT3 as the quinone reductase 2.
Authors: Nosjean Et al.
J Biol Chem 2000;275:31311
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