2-Phenylmelatonin

Catalog #: 0680
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0680/10
0680/50

2-Phenylmelatonin | CAS No. 151889-03-1 | Melatonin (MT) Receptor Agonists

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Description: Potent melatonin agonist

Chemical Name: N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity

2-Phenylmelatonin is a highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC₅₀ values for G protein activation in MT₁ and MT₂-transfected cells are 65 and 58 pM respectively.

Technical Data

M.Wt:

308.38

Formula:

C₁₉H₂₀N₂O₂

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at +4°C

CAS No:

151889-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2-Substituted 5-methoxy-N-acetyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity.
Spadoni et al.
J.Med.Chem., 1993;36:4069
Pharmacological characterization of the human melatonin Mel_1a receptor following stable transfection into NIH3T3 cells.
Nonno et al.
Br.J.Pharmacol., 1998;124:485
Ligand efficacy and potency at recombinant human MT₂ melatonin receptors: evidence for agonist activity of some mt₁-antagonists.
Nonno et al.
Br.J.Pharmacol., 1999;127:1288

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Citations for 2-Phenylmelatonin

The citations listed below are publications that use Tocris products. Selected citations for 2-Phenylmelatonin include:

3 Citations: Showing 1 - 3

A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
XFEL structures of the human MT₂ melatonin receptor reveal the basis of subtype selectivity.
Authors: Johansson Et al.
Nature 2019;569:289
Structural basis of ligand recognition at the human MT₁ melatonin receptor
Authors: Stauch Et al.
Nature 2019;569:284

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