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3-Mercaptopicolinic acid hydrochloride

Catalog #: 7577 Datasheet / COA / SDS

Discontinued Product

7577 has been discontinued.
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3-Mercaptopicolinic acid hydrochloride | CAS No. 320386-54-7 | PCK1
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Description: Phospoenolpyruvate carboxykinase (PEPCK) inhibitor; inhibits gluconeogenesis

Chemical Name: 3-Mercapto-2-pyridinecarboxylic acid hydrochloride

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Biological Activity

3-Mercaptopicolinic acid hydrochloride is a phospoenolpyruvate carboxykinase (PEPCK) inhibitor (IC50 = 7.5 μM at hPEPCK). Inhibits glucose synthesis. In vitro, 3-Mercaptopicolinic acid reduces proliferation of Treg cells, induces myogenic differentiation of C2C12 cells, and reduces colony growth formation of MCF7 cells. Also sensitizes melanoma cells to Vemurafenib (Cat. No. 7309) via inhibition of cytoplasmic PEPCK.

Technical Data

M.Wt:
191.63
Formula:
C6H5NO2S.HCl
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in water
Storage:
Store at -20°C
CAS No:
320386-54-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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