(-)-[3R,4S]-Chromanol 293B

Catalog #: 1475
3 Citations Datasheet / COA / SDS

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(-)-[3R,4S]-Chromanol 293B | CAS No. 163163-24-4 | Voltage-gated Potassium Channel Blockers

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Description: IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

Purity: ≥99%

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Product Details

Citations (3)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K⁺ current (I_Ks). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC₅₀ values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at K_V11.1 (hERG) channels (IC₅₀ > 30 μM).

Racemate also available.

Technical Data

M.Wt:

324.39

Formula:

C₁₅H₂₀N₂O₄S

Solubility:

Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming

Purity:

≥99%

Storage:

Store at RT

CAS No:

163163-24-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Racemate Available

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Molecular impact of MinK on the enantiospecific block of I_Ks by chromanols.
Lerche et al.
Br.J.Pharmacol., 2001;131:1503
A kinetic study on the stereospecific inhibition of KCNQ1 and I_Ks by the chromanol 293B.
Seebohm et al.
Br.J.Pharmacol., 2001;134:1647
Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels.
Yang et al.
J.Pharmacol.Exp.Ther., 2000;294:955

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Citations for (-)-[3R,4S]-Chromanol 293B

The citations listed below are publications that use Tocris products. Selected citations for (-)-[3R,4S]-Chromanol 293B include:

3 Citations: Showing 1 - 3

Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
Authors: Song Et al.
Nat.Card.Res. 2022;1:142
The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake.
Authors: Purtell Et al.
Neuropharmacology 2012;26:3252
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
Authors: Ma Et al.
FASEB J 2011;301:H2006

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