4-Chlorophenylguanidine hydrochloride
Purity: ≥98%
Biological Activity
4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of urokinase. Also a positive allosteric modulator at acid sensing ion channel 3 (ASIC3), which increases its pH sensitivity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator.
Agharkar & Gonzales
J.Pharmacol.Sci., 2017;133:184 -
Selective inhibition of urok. by substituted phenylguanidines: quantitative structure-activity relationship analyses.
Yang et al.
J.Med.Chem., 1990;33:2956
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Citation for 4-Chlorophenylguanidine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 4-Chlorophenylguanidine hydrochloride include:
1 Citation: Showing 1 - 1
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4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator.
Authors: Agharkar & Gonzales
J.Pharmacol.Sci. ;133:184
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