4-IPP

Catalog #: 3429
4 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3429/10
3429/50

4-IPP | CAS No. 41270-96-6 | Cytokine Compounds

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Description: Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate

Chemical Name: 4-Iodo-6-phenylpyrimidine

Purity: ≥98%

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Product Details

Citations (4)

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Biological Activity

4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.

Technical Data

M.Wt:

282.08

Formula:

C₁₀H₇IN₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

41270-96-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
Winner et al.
Cancer Res., 2008;68:7253

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Citations for 4-IPP

The citations listed below are publications that use Tocris products. Selected citations for 4-IPP include:

4 Citations: Showing 1 - 4

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression.
Authors: Justin D Et al.
Front Immunol 2020;11:1191
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
Authors: Subbannayya Et al.
J Biol Chem 2015;15:843
The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation.
Authors: Salazar Et al.
Mol Cancer 2014;13:198
Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses.
Authors: Takahashi Et al.
PLoS One 2013;8:e78250

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