4-PPBP maleate
Chemical Name: 4-Phenyl-1-(4-phenylbutyl)piperidine maleate
Purity: ≥99%
Biological Activity
4-PPBP maleate is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition.
Whittemore et al.
J.Pharmacol.Exp.Ther., 1997;282:326 -
Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high affinity σ ligands.
Glennon et al.
J.Med.Chem., 1991;34:3360
Product Datasheets
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Citation for 4-PPBP maleate
The citations listed below are publications that use Tocris products. Selected citations for 4-PPBP maleate include:
1 Citation: Showing 1 - 1
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σ receptor agonists provide neuroprotection in vitro by preserving bcl-2.
Authors: Yang Et al.
Front Behav Neurosci 2007;104:1179
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