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5-Azacytidine

Catalog #: 3842
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3842/50
5-Azacytidine | CAS No. 320-67-2 | Methyltransferase Inhibitors
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Description: DNA methyltransferase inhibitor

Chemical Name: 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

5-Azacytidine is a DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.

Technical Data

M.Wt:
244.2
Formula:
C8H12N4O5
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
320-67-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Azacitidine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for 5-Azacytidine

The citations listed below are publications that use Tocris products. Selected citations for 5-Azacytidine include:

6 Citations: Showing 1 - 6

  1. TET1 regulates fibroblast growth factor 8 transcription in Gn releasing hormone neurons.
    Authors: Linscott and Chung
    PLoS One  2019;14:e0220530
  2. Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth.
    Authors: Donald J Et al.
    Oncotarget  2017;8:44159-44170
  3. PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
    Authors: Chandrakanthan Et al.
    Proc Natl Acad Sci U S A  2016;113:E2306
  4. 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
    Authors: Bhuvanagiri Et al.
    EMBO Mol Med  2014;6:1593
  5. Progenitor cells identified by PDGFR-α expression in the developing and diseased human heart.
    Authors: Chong Et al.
    Cell Res  2013;22:1932
  6. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
    Authors: Perera Et al.
    PLoS One  2009;4:e4488

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