6-Hydroxydopamine hydrobromide
Chemical Name: 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
Biological Activity
6-Hydroxydopamine hydrobromide is a selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effect of 6-hydroxyDA on brain NE and DA: evidence for selective degeneration of catecholamine neurons.
Breese and Traylor
J.Pharmacol.Exp.Ther., 1970;174:413 -
Autoxidation and neurotoxicity of 6-hydroxyDA in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease.
Soto-Otero et al.
J.Neurochem., 2000;74:1605 -
Cell-permeable cAMP analog suppresses 6-hydroxyDA-induced apoptosis in PC12 cells through the activation of the Akt pathway.
Fujita et al.
Brain Res., 2006;1113:10
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Citations for 6-Hydroxydopamine hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for 6-Hydroxydopamine hydrobromide include:
11 Citations: Showing 1 - 10
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Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons
Authors: McIver Et al.
Cell Rep 2019;28:992
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External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway.
Authors: Fan
Proc Natl Acad Sci U S A. 2018;115(29):E6880
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CRO reduces L-dopa-induced dyskinesia severity in 6-hydroxyDA parkinson's disease model.
Authors: Chotibut Et al.
Mov Disord 2017;32:1547
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Assessment of the Protection of DArgic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model.
Authors: Sérriàre Et al.
PLoS One 2015;2:61
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Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model.
Authors: Ray Et al.
Cell Death Dis 2014;5:e984
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Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
Authors: Reinhardt Et al.
Neural Plast 2013;8:e59252
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ER stress inhibits neuronal death by promoting autophagy.
Authors: Fouillet Et al.
Front Med (Lausanne) 2012;8:915
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Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease.
Authors: Grau and Greene
Methods Mol Biol 2012;846:201
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Suppression of bladder overactivity by adenosine A2A receptor antagonist in a rat model of Parkinson disease.
Authors: Kitta Et al.
J Urol 2012;187:1890
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Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
Authors: Malagelada Et al.
J Neurosci 2010;30:1166
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RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation.
Authors: Malagelada Et al.
J Neurosci 2008;28:14363
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