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7α,25-Dihydroxycholesterol

Catalog #: 6277 Datasheet / COA / SDS

Discontinued Product

6277 has been discontinued.
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7α,25-Dihydroxycholesterol | CAS No. 64907-22-8 | Orphan 7-TM Receptor Agonists
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Description: Highly potent GPR183 (EBI2) agonist

Chemical Name: (3β,7α)-Cholest-5-ene-3,7,25-triol

Purity: ≥98%

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Biological Activity

7α,25-Dihydroxycholesterol is a highly potent GPR183 (EBI2) agonist (EC50 = 140 pM) and putative natural ligand for GPR183. Regulates migration of B and T cells expressing GPR183 in vivo. Desensitizes B cells and reduces their movement to splenic follicles.

Technical Data

M.Wt:
418.65
Formula:
C27H46O3
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
64907-22-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Oxysterols direct B-cell migration through EBI2.
    Liu et al.
    Nature., 2011;475:519
  2. Oxysterols direct immune cell migration via EBI2.
    Hannedouche et al.
    Nature., 2011;475:524

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