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8-Azaadenosine

Catalog #: 6868 Datasheet / COA / SDS
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6868/10
6868/50
8-Azaadenosine | CAS No. 10299-44-2 | Deaminase Inhibitors
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Description: ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal

Chemical Name: 3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine

Purity: ≥98%

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Biological Activity

8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.

Technical Data

M.Wt:
268.23
Formula:
C9H12N6O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
10299-44-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis.
    Zipeto et al.
    Cell Stem Cell, 2016;19:177
  2. ADARs edit microRNAs to promote leukemic stem cell activity.
    Zhang and Slack et al.
    Cell Stem Cell, 2016;19:141

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