Home / SOX1 / Human/Mouse/Rat SOX1 Antibody

Human/Mouse/Rat SOX1 Antibody

Catalog #: AF3369
136 Citations 4 Reviews Datasheet / COA / SDS
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AF3369
AF3369-SP
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Detection of Human SOX1 by Western Blot.
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Citations (136)
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Human/Mouse/Rat SOX1 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects human SOX1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human SOX1
Asn242-Gly379 (Leu276Ile)
Accession # NP_005977
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunohistochemistry
3-15 µg/mL
Immersion fixed paraffin-embedded sections of human brain (cortex)
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human SOX1 antibody by Western Blot. View Larger

Detection of Human SOX1 by Western Blot. Western blot shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry SOX1 antibody in ectoderm differentuiated BG01V Human Embryonic Stem Cells by Immunocytochemistry (ICC). View Larger

SOX1 in ectoderm differentuiated BG01V Human Embryonic Stem Cells. SOX1 was detected in immersion fixed BG01V human embryonic stem cells differentiated into neural progenitor cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Nestin was also detected using Mouse Anti-Mouse/Rat Nestin Monoclonal Antibody (MAB2736) and stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009). Specific staining of SOX1 was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.

Immunocytochemistry SOX1 antibody in differentiated NTera-2 Human Cell Line by Immunocytochemistry (ICC). View Larger

SOX1 in differentiated NTera‑2 Human Cell Line. SOX1 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line differentiated with retinoic acid using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green, upper panel; NL003) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry SOX1 antibody in Rat Cortical Stem Cells by Immunocytochemistry (ICC). View Larger

SOX1 in Rat Cortical Stem Cells. SOX1 was detected in immersion fixed rat cortical stem cells (NSC001) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry SOX1 antibody in Mouse Cortical Stem Cells by Immunocytochemistry (ICC). View Larger

SOX1 in Mouse Cortical Stem Cells. SOX1 was detected in immersion fixed mouse cortical stem cells (Catalog # NSC002) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry View Larger

SOX1 in Human Brain (Cortex). SOX1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in neuron. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western Detection of Human SOX1 antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Human SOX1 by Simple WesternTM. Simple Western lane view shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells, loaded at 0.2 mg/mL. A specific band was detected for SOX1 at approximately 50 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Immunocytochemistry/ Immunofluorescence Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence Characterization of NSCs and cortical neurons derived from FKRP‐ and CRISPR/Cas9 corrected‐iPSCsA, BRepresentative images of NSCs derived from FKRP‐ and corrected‐iPSC lines expressing SOX1, SOX2, and nestin.C, DQuantification of percentage of SOX1+ (C) and SOX2+ (D) cells in culture. The efficiency of neural induction is more than 99% in FKRP‐ and corrected‐iPSC (5D17, 5D23, and 3B17) lines. Data are mean ± s.d. n = 4 technical replicates.E, FFKRP‐ and corrected‐NSC lines can be further differentiated to cortical neural progenitor cells, expressing PAX6, OTX2, and vimentin.G–IQuantification of percentage of PAX6+ (G) and OTX2+ (H) cells in culture. About 91‐98% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express PAX6 (G). About 93‐96% of cells derived from FKRP, 5D17, 5D23, and 3B17 NSC lines express OTX2 (H). Of the OTX2+ population, about 60‐67% cells are also Ki67+ cycling progenitors (I). Data are mean ± s.d. n = 4 technical replicates.J, KGlutamatergic projection neurons derived from FKRP and corrected (5D17, 5D23, and 3B17) progenitor cells. The vast majority of neurons contain vGlut1+ punctae in their neurites (labeled by Tuj1). Right panels are enlarged images from the insets of left panels.Data information: Scale bars, 50 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/31566294), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (https://linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence Expression of NSUN2 in the Human Developing Brain and NES Cells(A) DAPI-stained human embryo (6 weeks of gestation) marked for prosencephalon, mesencephalon, and rhombencephalon. Region in square is magnified in (B). Scale bar, 1 mm.(B) Prosencephalon labeled for NSUN2 and SOX1. Region in squares are magnified in (b′) and (b″). Arrows indicate NSUN2-positive cells. Scale bar, 100 μm.(C–F) Bright-field image (C) and immunofluorescence (D–F) of AF22 (upper panels) and Sai1 (lower panels) cells labeled for Nestin (D), SOX2 (E), and beta III-tubulin (F). Scale bar, 50 μm.(G and H) NES cells co-labeled for NSUN2 and Nestin (NES) (G) or SOX1 (H).(I) Differentiation protocol.(J–L) Differentiated AF22 and Sai1 cells (day 15) labeled for Nestin (NES; J), SOX2 (K), and beta III-tubulin (L). Scale bars: 50 μm.(M) Western blot for NSUN2, beta III-tubulin (TUBB3), GFAP, SOX2, and Nestin during differentiation (days). alpha -Tubulin served as loading control.Nuclei are counterstained with DAPI (A, B, D–F, J–L). Image collected and cropped by CiteAb from the following publication (https://linkinghub.elsevier.com/retrieve/pii/S2213671116302764), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human SOX1 by Immunocytochemistry/Immunofluorescence GPI anchored proteins are required for neural differentiation.(A). Representative example of images of hiPSC-derived EBs and EB-derived rosettes during neural differentiation. Neural induction and rosette formation upon neural induction was assessed in three cell lines using a serum-free EB generation method. On day 2 (left) of hiPSC-derived EBs from PIGAwt, PIGAc.1234C>T, and PIGAnull after forced aggregation (20X magnification, scale bar is 50μm). On day 4 (middle), single homogeneous hiPSC-EBs collected were pooled in a 10 cm plate (4X magnification, scale bar is 100μm). On day 11 (right), neuroepithelial cells appeared and neural tube-like rosettes formed (EB-derived rosettes) and scale bar is 50μm. (B). Neural induction rates from EB-derived rosettes. The percentage of EB derived rosettes was 88.8% ± 4.6, 75.5% ± 9.8 and 68.4% ± 6.9 for PIGAwt, PIGAc.1234C>T, and PIGAnull, respectively. PIGAwt versus PIGAc.1234C>T (p>0.05, NS) and PIGAwt versus PIGAnull (*p<0.05, one way ANOVA and Multiple comparisons). Neural induction from PIGAnull hiPSCs was less than 70%. All values were mean ±SD. (C). Representative confocal images showing expression of neuron stem cell marker SOX1 (in red) combined proliferation by EdU labeling in hNPCs derived from isolated neural rosettes. Nuclei were visualized with DAPI (blue) and scale bar 100μm. (D). Representative confocal images showing expression of neuron progenitor marker PAX6 (in red) and combined proliferation by EdU (in green) in hNPCs derived from isolated neural rosettes. Nuclei were visualized with DAPI (blue) and scale bar 200μm. hNPCs from PIGAnull cell lines showed reduced expression of SOX1 and PAX6. (E). Proliferation rate in hNPCs was assessed and plotted in all three cell lines. EdU positive cells were counted and normalized by total number of nuclei staining with DAPI (blue). Proliferation was significantly decreased in PIGAnull and PIGAc.1234C>T compared to PIGAwt. (F). Graphs depict the percentage of positive cells for SOX-1 (left) and Pax6 (right) in hNPCs derived from PIGAwt, PIGAc.1234C>T, and PIGAnull hiPSC lines. The hNPCs derived from the PIGAnull hiPSCs showed significantly decreased expression of SOX1 and PAX6. Similar levels of SOX1 and PAX6 were expressed in hNPCs from PIGAwt and PIGAc.1234C>T. All values represent mean ± SD. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0174074), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SOX1

SOX1 is a 39 kDa transcription factor that belongs to the SOXB1 subgroup. Within the developing CNS, SOX1 maintains neural cells in an undifferentiated state and has been used as a marker for neural stem cells. Human and mouse SOX1 share 97% amino acid sequence identity.

Long Name
SRY-related HMG-box 1
Entrez Gene IDs
6656 (Human); 20664 (Mouse)
Alternate Names
SOX1; SRY (sex determining region Y)-box 1; SRY-related HMG-box gene 1; transcription factor SOX-1

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Citations for Human/Mouse/Rat SOX1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

136 Citations: Showing 1 - 10
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  1. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency
    Authors: Hannah T. Stuart, Giuliano G. Stirparo, Tim Lohoff, Lawrence E. Bates, Masaki Kinoshita, Chee Y. Lim et al.
    Cell Stem Cell
  2. Microglia-secreted TNF-alpha affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors
    Authors: Shirley D. Wenker, María Isabel Farias, Victoria Gradaschi, Corina Garcia, Juan Beauquis, María Celeste Leal et al.
    PLoS One
  3. Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor
    Authors: Antigoni Gogolou, Celine Souilhol, Ilaria Granata, Filip J Wymeersch, Ichcha Manipur, Matthew Wind et al.
    eLife
  4. Comparison of two protocols for the generation of iPSC-derived human astrocytes
    Authors: Patrycja Mulica, Carmen Venegas, Zied Landoulsi, Katja Badanjak, Sylvie Delcambre, Maria Tziortziou et al.
    Biol Proced Online
  5. Loss of Protein Function Causing Severe Phenotypes of Female-Restricted Wieacker Wolff Syndrome due to a Novel Nonsense Mutation in the ZC4H2 Gene
    Authors: Jing-Jing Sun, Qin Cai, Miao Xu, Yan-Na Liu, Wan-Rui Li, Juan Li et al.
    Genes (Basel)
  6. An in vitro stem cell model of human epiblast and yolk sac interaction
    Authors: KM Mackinlay, BA Weatherbee, V Souza Rosa, CE Handford, G Hudson, T Coorens, LV Pereira, S Behjati, L Vallier, MN Shahbazi, M Zernicka-G
    Elife, 2021-08-17;10(0):.
  7. Human axial progenitors generate trunk neural crest cells in vitro
    Authors: Thomas JR Frith, Ilaria Granata, Matthew Wind, Erin Stout, Oliver Thompson, Katrin Neumann et al.
    eLife
  8. AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay
    Authors: Hana Cho, Elizabeth T. Abshire, Maximilian W. Popp, Christoph Pröschel, Joshua L. Schwartz, Gene W. Yeo et al.
    Molecular Cell
  9. Geminin is required for Hox gene regulation to pattern the developing limb
    Authors: Emily M.A. Lewis, Savita Sankar, Caili Tong, Ethan S. Patterson, Laura E. Waller, Paul Gontarz et al.
    Developmental Biology
  10. A New Approach to Generate Gastruloids to Develop Anterior Neural Tissues
    Authors: Mehmet Girgin, Nicolas Broguiere, Lorenzo Mattolini, Matthias Lutolf
    BIO-PROTOCOL
  11. An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates
    Authors: Julia Tischler, Zoe Swank, Hao-An Hsiung, Stefano Vianello, Matthias P. Lutolf, Sebastian J. Maerkl
    Cell Reports Methods
  12. iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated alpha -tubulin defect which improves after iHDAC6 treatment in Rett syndrome
    Authors: Elisa Landucci, Margherita Brindisi, Laura Bianciardi, Lorenza M. Catania, Sergio Daga, Susanna Croci et al.
    Experimental Cell Research
  13. Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation
    Authors: Miho Isoda, Tsukasa Sanosaka, Ryo Tomooka, Yo Mabuchi, Munehisa Shinozaki, Tomoko Andoh-Noda et al.
    Communications Biology
  14. The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
    Authors: Ralda Nehme, Olli Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen et al.
    Nature Communications
  15. Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
    Authors: Z Liu, M Osipovitch, A Benraiss, NPT Huynh, R Foti, J Bates, D Chandler-M, RL Findling, PJ Tesar, M Nedergaard, MS Windrem, SA Goldman
    Cell Rep, 2019-06-25;27(13):3832-3843.e6.
  16. Single-cell RNA sequencing of neural stem cells derived from human trisomic iPSCs reveals the abnormalities during neural differentiation of Down syndrome
    Authors: Jia-jun Qiu, Yan-na Liu, Hao Wei, Fanyi Zeng, Jing-bin Yan
    Frontiers in Molecular Neuroscience
  17. A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome
    Authors: Keiji Kawatani, Toshihiko Nambara, Nobutoshi Nawa, Hidetaka Yoshimatsu, Haruna Kusakabe, Katsuya Hirata et al.
    Communications Biology
  18. Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers
    Authors: Hayley Robinson, Sk Imran Ali, Martha Elena Diaz-Hernandez, Rodrigo Lopez-Gonzalez
    Frontiers in Cell and Developmental Biology
  19. Environmentally relevant developmental methylmercury exposures alter neuronal differentiation in a human-induced pluripotent stem cell model
    Authors: Lisa M. Prince, M. Diana Neely, Emily B. Warren, Morgan G. Thomas, Madeline R. Henley, Kiara K. Smith et al.
    Food and Chemical Toxicology
  20. Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
    Authors: Clara Berenguer-Escuder, Dajana Grossmann, Paul Antony, Giuseppe Arena, Kobi Wasner, François Massart et al.
    Human Molecular Genetics
  21. Human iNPC therapy leads to improvement in functional neurologic outcomes in a pig ischemic stroke model
    Authors: Vivian W. Lau, Simon R. Platt, Harrison E. Grace, Emily W. Baker, Franklin D. West
    Brain and Behavior
  22. Spinal dI4 Interneuron Differentiation From Human Pluripotent Stem Cells
    Authors: Jia Xu, Liang-Jiang Huang, Zhengyu Fang, Hong-Mei Luo, Yun-Qiang Chen, Ya-Jie Li et al.
    Frontiers in Molecular Neuroscience
  23. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes
    Authors: Panagiotis Douvaras, Tomasz Rusielewicz, Kwi Hye Kim, Jeffery D. Haines, Patrizia Casaccia, Valentina Fossati
    International Journal of Molecular Sciences
  24. Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling
    Authors: Kent Imaizumi, Koki Fujimori, Seiji Ishii, Asako Otomo, Yasushi Hosoi, Hiroaki Miyajima et al.
    eNeuro
  25. iPS-derived neural stem cells for disease modeling and evaluation of therapeutics for mucopolysaccharidosis type II
    Authors: Junjie Hong, Yu-Shan Cheng, Shu Yang, Manju Swaroop, Miao Xu, Jeanette Beers et al.
    Experimental Cell Research
  26. Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury
    Authors: Kota Kojima, Hiroyuki Miyoshi, Narihito Nagoshi, Jun Kohyama, Go Itakura, Soya Kawabata et al.
    Stem Cells Translational Medicine
  27. Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
    Authors: McCreery, KP;Stubb, A;Stephens, R;Fursova, NA;Cook, A;Kruse, K;Michelbach, A;Biggs, LC;Keikhosravi, A;Nykänen, S;Hydén-Granskog, C;Zou, J;Lackmann, JW;Niessen, CM;Vuoristo, S;Miroshnikova, YA;Wickström, SA;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells, Embryo
    Applications: Immunohistochemistry, Immunocytochemistry
  28. KIF1A, R1457Q, and P1688L Mutations Induce Protein Abnormal Aggregation and Autophagy Impairment in iPSC-Derived Motor Neurons
    Authors: Zhao, M;Wang, J;Liu, M;Xu, Y;Huang, J;Zhang, Y;He, J;Gu, A;Liu, M;Liu, X;
    Biomedicines
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  29. Generation of a human induced pluripotent stem cell line from a patient with GM3 synthase deficiency using self-replicating RNA vector
    Authors: Tonin, R;Feo, F;Falliano, S;Giunti, L;Calamai, M;Procopio, E;Mari, F;Sciruicchio, V;Conti, V;Fanelli, I;Bambi, F;Guerrini, R;Morrone, A;
    Stem cell research
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  30. Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains
    Authors: Kanemura, Y;Yamamoto, A;Katsuma, A;Fukusumi, H;Shofuda, T;Kanematsu, D;Handa, Y;Sumida, M;Yoshioka, E;Mine, Y;Yamaguchi, R;Okada, M;Igarashi, M;Sekino, Y;Shirao, T;Nakamura, M;Okano, H;
    Cells
    Species: Human, Xenograft
    Sample Types: Whole Cells, Whole Tissue
    Applications: Immunohistochemistry, Immunocytochemistry
  31. Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids
    Authors: Sun, Z;Chen, Z;Yin, M;Wu, X;Guo, B;Cheng, X;Quan, R;Sun, Y;Zhang, Q;Fan, Y;Jin, C;Yin, Y;Hou, X;Liu, W;Shu, M;Xue, X;Shi, Y;Chen, B;Xiao, Z;Dai, J;Zhao, Y;
    Cell stem cell
    Species: Rabbit, Rat
    Sample Types: Organoid
    Applications: Immunohistochemistry
  32. TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome
    Authors: Werren, EA;LaForce, GR;Srivastava, A;Perillo, DR;Li, S;Johnson, K;Baris, S;Berger, B;Regan, SL;Pfennig, CD;de Munnik, S;Pfundt, R;Hebbar, M;Jimenez-Heredia, R;Karakoc-Aydiner, E;Ozen, A;Dmytrus, J;Krolo, A;Corning, K;Prijoles, EJ;Louie, RJ;Lebel, RR;Le, TL;Amiel, J;Gordon, CT;Boztug, K;Girisha, KM;Shukla, A;Bielas, SL;Schaffer, AE;
    Nature communications
    Species: Human, Mouse
    Sample Types: Embryo, Organoid
    Applications: IHC
  33. Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids
    Authors: Capauto, D;Wang, Y;Wu, F;Norton, S;Mariani, J;Inoue, F;Crawford, GE;Ahituv, N;Abyzov, A;Vaccarino, FM;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  34. BAF45D-binding to HOX genes was differentially targeted in H9-derived spinal cord neural stem cells
    Authors: Liu, C;Xie, Y;Chen, X;Liu, L;Liu, C;Yin, Z;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  35. Generation of a human induced pluripotent stem cell line (SMUSHi002-A) from an ALS patient carrying a heterozygous mutation c.1562G > A in the FUS gene
    Authors: Tang, M;Xiong, M;Zhou, W;Lei, J;Huang, M;Huang, C;Wang, F;Liu, J;Li, J;Xu, X;
    Stem cell research
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC/IF, Flow Cytometry
  36. Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease
    Authors: Park, S;Park, CW;Eom, JH;Jo, MY;Hur, HJ;Choi, SK;Lee, JS;Nam, ST;Jo, KS;Oh, YW;Lee, J;Kim, S;Kim, DH;Park, CY;Kim, SJ;Lee, HY;Cho, MS;Kim, DS;Kim, DW;
    Cell stem cell
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  37. Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
    Authors: Tao, Y;Li, X;Dong, Q;Kong, L;Petersen, AJ;Yan, Y;Xu, K;Zima, S;Li, Y;Schmidt, DK;Ayala, M;Mathivanan, S;Sousa, AMM;Chang, Q;Zhang, SC;
    Nature biotechnology
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  38. The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor
    Authors: Jaratsittisin, J;Sornjai, W;Chailangkarn, T;Jongkaewwattana, A;Smith, DR;
    PloS one
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  39. Determinants of astrocytic pathology in stem cell models of primary tauopathies
    Authors: Fiock, KL;Hook, JN;Hefti, MM;
    Acta neuropathologica communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Generation and characterization of induced pluripotent stem cells from a Parkinson's disease patient carrying the digenic LRRK2 p.G2019S and GBA1 p.N409S mutations
    Authors: Oleksy, C;Massart, F;Goldwurm, S;Arado, A;Arena, G;Boussaad, I;Krüger, R;
    Stem cell research
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  41. Characterization of an induced pluripotent stem cell line NCHi011-A from a 23-year-old female with Alagille Syndrome harboring a heterozygous JAG1 pathogenic variant
    Authors: Stanberry, I;Cunningham, D;Ye, S;Alonzo, M;Zhao, MT;Garg, V;Lilly, B;
    Stem cell research
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  42. RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling
    Authors: Militi, S;Nibhani, R;Jalali, M;Pauklin, S;
    Cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  43. Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids
    Authors: Capauto, D;Wang, Y;Wu, F;Norton, S;Mariani, J;Inoue, F;Crawford, GE;PsychENCODE Consortium, ;Ahituv, N;Abyzov, A;Vaccarino, FM;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  44. Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
    Authors: Jourdon, A;Wu, F;Mariani, J;Capauto, D;Norton, S;Tomasini, L;Amiri, A;Suvakov, M;Schreiner, JD;Jang, Y;Panda, A;Nguyen, CK;Cummings, EM;Han, G;Powell, K;Szekely, A;McPartland, JC;Pelphrey, K;Chawarska, K;Ventola, P;Abyzov, A;Vaccarino, FM;
    Nature neuroscience
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  45. Generation of iPSC line NCHi012-A from a patient with Alagille syndrome and heterozygous pathogenic variant in the JAG1 gene
    Authors: Cunningham, D;Stanberry, I;Ye, S;Alonzo, M;Zhao, MT;Garg, V;Lilly, B;
    Stem cell research
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  46. Mitotic bookmarking by SWI/SNF subunits
    Authors: Zhu, Z;Chen, X;Guo, A;Manzano, T;Walsh, PJ;Wills, KM;Halliburton, R;Radko-Juettner, S;Carter, RD;Partridge, JF;Green, DR;Zhang, J;Roberts, CWM;
    Nature
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  47. An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons
    Authors: Cukier, HN;Duarte, CL;Laverde-Paz, MJ;Simon, SA;Van Booven, DJ;Miyares, AT;Whitehead, PL;Hamilton-Nelson, KL;Adams, LD;Carney, RM;Cuccaro, ML;Vance, JM;Pericak-Vance, MA;Griswold, AJ;Dykxhoorn, DM;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  48. SOX1 Functions as a Tumor Suppressor by Repressing HES1 in Lung Cancer
    Authors: Chang, SY;Wu, TH;Shih, YL;Chen, YC;Su, HY;Chian, CF;Lin, YW;
    Cancers
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  49. Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
    Authors: J Sidhaye, P Trepte, N Sepke, M Novatchkov, M Schutzbier, G Dürnberger, K Mechtler, JA Knoblich
    Elife, 2023-03-29;12(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  50. Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments
    Authors: JT Czerminski, OD King, JB Lawrence
    Frontiers in Neuroscience, 2023-02-03;16(0):972201.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  51. Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation
    Authors: J Sun, S Osenberg, A Irwin, LH Ma, N Lee, Y Xiang, F Li, YW Wan, IH Park, M Maletic-Sa, N Ballas
    Cell Reports, 2023-01-05;42(1):111942.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  52. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers
    Authors: R Yelagandul, K Stecher, M Novatchkov, L Michetti, G Michlits, J Wang, P Hofbauer, G Vainorius, C Pribitzer, L Isbel, S Mendjan, D Schübeler, U Elling, J Brennecke, O Bell
    Nature Cell Biology, 2023-01-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  53. Generation of a human iPSC line (CIBi014-A) from a patient with Parkinson's disease carrying a novel heterozygotic PARK8 (LRRK2) mutation
    Authors: L Li, X Si, J Yang, M Lei, H Liu, J Ruan, H Fu, W Li, H Yang, X Lei, H Sang
    Stem Cell Research, 2022-12-09;66(0):102995.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  54. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
    Authors: MV Brady, J Mariani, Y Koca, A Szekely, RA King, MH Bloch, A Landeros-W, JF Leckman, FM Vaccarino
    Molecular Psychiatry, 2022-11-29;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  55. Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with congenital heart disease (CHD)
    Authors: H Lin, SQ Ye, ZH Xu, JS Penaloza, M Aljuhani, T Vetter, MT Zhao, KL McBride
    Stem Cell Research, 2022-10-31;65(0):102958.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  56. The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing
    Authors: Kim J, Muraoka M, Okada H et al.
    PLOS Genetics
  57. Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Promotes Forelimb Functional Recovery after Cervical Spinal Cord Injury
    Authors: Y Zheng, CM Gallegos, H Xue, S Li, DH Kim, H Zhou, X Xia, Y Liu, Q Cao
    Cells, 2022-09-05;11(17):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  58. Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects
    Authors: M Rhinn, I Zapata-Bod, A Klein, JL Plassat, T Knauer-Mey, WM Keyes
    PloS Biology, 2022-06-14;20(6):e3001664.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  59. Generation and characterization of a genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A)
    Authors: P Mencke, I Boussaad, G Önal, AJA Kievit, AJW Boon, W Mandemaker, V Bonifati, R Krüger
    Stem Cell Research, 2022-04-26;62(0):102792.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: ICC
  60. Generation of the human induced pluripotent stem cell line (IBKMOLi002-A) from PBMCs of a patient carrying the heterozygous L271H mutation of the voltage-gated calcium channel subunit Cav1.3-encoding CACNA1D gene
    Authors: M Tisch, M Carmen De, M Suarez-Cub, C Fauth, M Defrancesc, J Zschocke, K Günther, F Edenhofer
    Stem Cell Research, 2022-04-09;61(0):102784.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  61. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes
    Authors: Görkem Garipler, Congyi Lu, Alexis Morrissey, Lorena S. Lopez-Zepeda, Yingzhen Pei, Simon E. Vidal et al.
    Cell Reports
  62. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes
    Authors: Görkem Garipler, Congyi Lu, Alexis Morrissey, Lorena S. Lopez-Zepeda, Yingzhen Pei, Simon E. Vidal et al.
    Cell Reports
  63. BRN2 as a key gene drives the early primate telencephalon development
    Authors: X Zhu, Y Guo, C Chu, D Liu, K Duan, Y Yin, C Si, Y Kang, J Yao, X Du, J Li, S Zhao, Z Ai, Q Zhu, W Ji, Y Niu, T Li
    Science Advances, 2022-03-04;8(9):eabl7263.
    Species: Primate (Macaca fascicularis)
    Sample Types: Whole Tissue
    Applications: IHC
  64. G-quadruplex DNA structures in human stem cells and differentiation
    Authors: KG Zyner, A Simeone, SM Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill, S Balasubram
    Nature Communications, 2022-01-10;13(1):142.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  65. Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors
    Authors: HS Meharena, A Marco, V Dileep, ER Lockshin, GY Akatsu, J Mullahoo, LA Watson, T Ko, LN Guerin, F Abdurrob, S Rengarajan, M Papanastas, JD Jaffe, LH Tsai
    Cell Stem Cell, 2022-01-06;29(1):116-130.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  66. Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration
    Authors: Fathi A, Mathivanan S, Kong L et al.
    Aging Cell
  67. Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
    Authors: T Pachano, V Sánchez-Ga, T Ealo, M Mariner-Fa, T Bleckwehl, HG Asenjo, P Respuela, S Cruz-Molin, M Muñoz-San, E Haro, WFJ van IJcken, D Landeira, A Rada-Igles
    Nature Genetics, 2021-06-28;53(7):1036-1049.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  68. Derivation of iPSC line UMi029-A bearing a hearing-loss associated variant in the SMPX gene
    Authors: DM Dykxhoorn, X Tong, NC Gosstola, XZ Liu
    Stem Cell Research, 2021-05-24;54(0):102405.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  69. Donor cell memory confers a metastable state of directly converted cells
    Authors: KP Kim, C Li, D Bunina, HW Jeong, J Ghelman, J Yoon, B Shin, H Park, DW Han, JB Zaugg, J Kim, T Kuhlmann, RH Adams, KM Noh, SA Goldman, HR Schöler
    Cell Stem Cell, 2021-04-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  70. Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly
    Authors: V Krenn, C Bosone, TR Burkard, J Spanier, U Kalinke, A Calistri, C Salata, R Rilo Chris, P Pestana Ga, A Mirazimi, JA Knoblich
    Cell Stem Cell, 2021-04-09;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  71. Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury
    Authors: C Gong, X Zheng, F Guo, Y Wang, S Zhang, J Chen, X Sun, SZA Shah, Y Zheng, X Li, Y Yin, Q Li, X Huang, T Guo, X Han, SC Zhang, W Wang, H Chen
    Cell Reports, 2021-03-23;34(12):108889.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  72. A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities
    Authors: T Malankhano, L Suldina, E Grigor'eva, S Medvedev, J Minina, K Morozova, E Kiseleva, S Zakian, A Malakhova
    J Pers Med, 2020-11-09;10(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  73. Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery
    Authors: A Lundin, MJ Porritt, H Jaiswal, F Seeliger, C Johansson, AW Bidar, L Badertsche, S Wimberger, EJ Davies, E Hardaker, CP Martins, E James, T Admyre, A Taheri-Gha, J Bradley, A Schantz, B Alaeimahab, M Clausen, X Xu, LM Mayr, R Nitsch, M Bohlooly-Y, ST Barry, M Maresca
    Nat Commun, 2020-09-29;11(1):4903.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  74. A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells
    Authors: JM Dias, Z Alekseenko, A Jeggari, M Boareto, J Vollmer, M Kozhevniko, H Wang, MP Matise, A Alexeyenko, D Iber, J Ericson
    Science Advances, 2020-09-16;6(38):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  75. 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates
    Authors: K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake
    Sci Rep, 2020-08-20;10(1):14047.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  76. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an A&beta-Induced Gene Regulatory Network
    Authors: S Martins, A Müller-Sch, L Erichsen, M Bohndorf, W Wruck, K Sleegers, C Van Broeck, C Korth, J Adjaye
    Int J Mol Sci, 2020-06-25;21(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  77. Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation
    Authors: V Meraviglia, CH Arendzen, M Tok, C Freund, AS Maione, E Sommariva, M Bellin
    Stem Cell Res, 2020-05-05;46(0):101835.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  78. Generation of two human induced pluripotent stem cell lines, LUMCi020-A and LUMCi021-A, from two patients with Catecholaminergic Polymorphic Ventricular Tachycardia carrying heterozygous mutations in the RYR2 gene
    Authors: V Meraviglia, CH Arendzen, C Freund, DE Atsma, CL Mummery, M Bellin
    Stem Cell Res, 2020-04-08;45(0):101764.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  79. Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency
    Authors: N Bredenkamp, J Yang, J Clarke, GG Stirparo, F von Meyenn, S Dietmann, D Baker, R Drummond, Y Ren, D Li, C Wu, M Rostovskay, S Eminli-Mei, A Smith, G Guo
    Stem Cell Reports, 2019-11-07;13(6):1083-1098.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  80. Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells
    Authors: P Wörsdörfer, N Dalda, A Kern, S Krüger, N Wagner, CK Kwok, E Henke, S Ergün
    Sci Rep, 2019-10-30;9(1):15663.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  81. The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
    Authors: B Di Stefano, EC Luo, C Haggerty, S Aigner, J Charlton, J Brumbaugh, F Ji, I Rabano Jim, KJ Clowers, AJ Huebner, K Clement, I Lipchina, MAC de Kort, A Anselmo, J Pulice, MFM Gerli, H Gu, SP Gygi, RI Sadreyev, A Meissner, GW Yeo, K Hochedling
    Cell Stem Cell, 2019-10-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  82. Establishment of PITX3-mCherry knock-in reporter human embryonic stem cell line (WAe009-A-23)
    Authors: S Park, JE Yoo, DR Lee, J Jang, MS Cho, DS Kim, DW Kim
    Stem Cell Res, 2019-07-18;39(0):101499.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  83. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis
    Authors: M Huang, J Tailor, Q Zhen, AH Gillmor, ML Miller, H Weishaupt, J Chen, T Zheng, EK Nash, LK McHenry, Z An, F Ye, Y Takashima, J Clarke, H Ayetey, FMG Cavalli, B Luu, BS Moriarity, S Ilkhanizad, L Chavez, C Yu, KM Kurian, T Magnaldo, N Sevenet, P Koch, SM Pollard, P Dirks, MP Snyder, DA Largaespad, YJ Cho, JJ Phillips, FJ Swartling, AS Morrissy, M Kool, SM Pfister, MD Taylor, A Smith, WA Weiss
    Cell Stem Cell, 2019-06-13;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  84. Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity
    Authors: S Chanda, CE Ang, QY Lee, M Ghebrial, D Haag, Y Shibuya, M Wernig, TC Südhof
    Cell Stem Cell, 2019-05-30;25(1):103-119.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  85. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
    Authors: J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty
    PLoS ONE, 2018-12-12;13(12):e0208110.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  86. Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys
    Authors: Y Kang, Z Ai, K Duan, C Si, Y Wang, Y Zheng, J He, Y Yin, S Zhao, B Niu, X Zhu, L Liu, L Xiang, L Zhang, Y Niu, W Ji, T Li
    Cell Rep, 2018-11-27;25(9):2563-2576.e9.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: ICC
  87. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
    Authors: AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar
    Nat Commun, 2018-09-13;9(1):3708.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  88. Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming
    Authors: AD Senft, I Costello, HW King, AW Mould, EK Bikoff, EJ Robertson
    Cell Rep, 2018-08-21;24(8):1977-1985.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  89. Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro
    Authors: CV Latchouman, L Jackson, MSE Sendi, KF Tehrani, LJ Mortensen, SL Stice, M Ghovanloo, L Karumbaiah
    Sci Rep, 2018-07-19;8(1):10957.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  90. TFAP2C regulates transcription in human naive pluripotency by opening enhancers
    Authors: WA Pastor, W Liu, D Chen, J Ho, R Kim, TJ Hunt, A Lukianchik, X Liu, JM Polo, SE Jacobsen, AT Clark
    Nat. Cell Biol., 2018-04-25;20(5):553-564.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  91. Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells
    Authors: JY Kim, JS Lee, HS Hwang, DR Lee, CY Park, SJ Jung, YR You, DS Kim, DW Kim
    Exp. Mol. Med., 2018-04-13;50(4):24.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  92. Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation
    Authors: NS Corsini, AM Peer, P Moeseneder, M Roiuk, TR Burkard, HC Theussl, I Moll, JA Knoblich
    Cell Stem Cell, 2018-04-05;22(4):543-558.e12.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  93. Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells
    Authors: M Zhang, J Ngo, F Pirozzi, YP Sun, A Wynshaw-Bo
    Stem Cell Res Ther, 2018-03-15;9(1):67.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  94. Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease
    Authors: L Marrone, C Bus, D Schöndorf, JC Fitzgerald, M Kübler, B Schmid, P Reinhardt, L Reinhardt, M Deleidi, T Levin, A Meixner, B Klink, M Glatza, CJ Gloeckner, T Gasser, J Sternecker
    PLoS ONE, 2018-03-07;13(3):e0192497.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  95. Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells
    Authors: P Walsh, V Truong, C Hill, ND Stoflet, J Baden, WC Low, SA Keirstead, JR Dutton, AM Parr
    Cell Transplant, 2017-12-01;26(12):1890-1902.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  96. Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells
    Authors: Y Li, R Wang, N Qiao, G Peng, K Zhang, K Tang, JJ Han, N Jing
    J. Biol. Chem., 2017-09-26;292(48):19590-19604.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  97. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model
    Authors: X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
    PLoS ONE, 2017-04-25;12(4):e0174074.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  98. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
    Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
    Am. J. Hum. Genet., 2017-03-30;100(4):617-634.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  99. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
    Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
    PLoS ONE, 2017-02-13;12(2):e0171947.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  100. Dynamic behaviour of human neuroepithelial cells in the developing forebrain
    Authors: L Subramania, M Bershteyn, MF Paredes, AR Kriegstein
    Nat Commun, 2017-01-31;8(0):14167.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  101. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia
    Authors: M Bershteyn, TJ Nowakowski, AA Pollen, E Di Lullo, A Nene, A Wynshaw-Bo, AR Kriegstein
    Cell Stem Cell, 2017-01-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  102. Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and�Motility
    Stem Cell Reports, 2016-12-29;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  103. Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state
    Authors: Rui Gao
    Biomaterials, 2016-12-10;119(0):53-67.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  104. Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A
    Stem Cells Transl Med, 2016-08-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-Fr
  105. Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.
    Authors: Nagaoka M, Kobayashi M, Kawai C, Mallanna S, Duncan S
    PLoS ONE, 2015-08-26;10(8):e0136350.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  106. Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.
    Authors: Paull D, Sevilla A, Zhou H, Hahn A, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard C, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz D, Martinez H, Malicdan M, Weiss K, Vensand L, Dusenberry C, Polus H, Sy K, Kahler D, Gahl W, Solomon S, Chang S, Meissner A, Eggan K, Noggle S
    Nat Methods, 2015-08-03;12(9):885-92.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  107. Derivation and long-term culture of transgene-free human induced pluripotent stem cells on synthetic substrates.
    Authors: Villa-Diaz L, Kim J, Lahann J, Krebsbach P
    Stem Cells Transl Med, 2014-10-13;3(12):1410-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  108. iPSC-Derived neural stem cells act via kinase inhibition to exert neuroprotective effects in spinal muscular atrophy with respiratory distress type 1.
    Authors: Simone C, Nizzardo M, Rizzo F, Ruggieri M, Riboldi G, Salani S, Bucchia M, Bresolin N, Comi G, Corti S
    Stem Cell Reports, 2014-07-04;3(2):297-311.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  109. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression.
    Authors: Ferrarese R, Harsh G, Yadav A, Bug E, Maticzka D, Reichardt W, Dombrowski S, Miller T, Masilamani A, Dai F, Kim H, Hadler M, Scholtens D, Yu I, Beck J, Srinivasasainagendra V, Costa F, Baxan N, Pfeifer D, von Elverfeldt D, Backofen R, Weyerbrock A, Duarte C, He X, Prinz M, Chandler J, Vogel H, Chakravarti A, Rich J, Carro M, Bredel M
    J Clin Invest, 2014-05-27;124(7):2861-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  110. Translating dosage compensation to trisomy 21.
    Authors: Jiang J, Jing Y, Cost G, Chiang J, Kolpa H, Cotton A, Carone D, Carone B, Shivak D, Guschin D, Pearl J, Rebar E, Byron M, Gregory P, Brown C, Urnov F, Hall L, Lawrence J
    Nature, 2013-07-17;500(7462):296-300.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  111. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
    Authors: Najm, Fadi J, Lager, Angela M, Zaremba, Anita, Wyatt, Krysta, Caprariello, Andrew V, Factor, Daniel C, Karl, Robert T, Maeda, Tadao, Miller, Robert H, Tesar, Paul J
    Nat Biotechnol, 2013-04-14;31(5):426-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  112. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
    Authors: Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel C, Hoing S, Moritz S, Parga J, Wagner L, Bruder J, Wu G, Schmid B, Ropke A, Klingauf J, Schwamborn J, Gasser T, Scholer H, Sterneckert J
    PLoS ONE, 2013-03-22;8(3):e59252.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  113. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice.
    Authors: Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y
    J. Neurosci., 2009-04-08;29(14):4484-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  114. An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids
    Authors: María José Castellanos-Montiel, Mathilde Chaineau, Anna Kristyna Franco-Flores, Ghazal Haghi, Dulce Carrillo-Valenzuela, Wolfgang E. Reintsch et al.
    Cells
  115. Biochemical Characteristics of iPSC-Derived Dopaminergic Neurons from N370S GBA Variant Carriers with and without Parkinson’s Disease
    Authors: Elena V. Grigor’eva, Alena E. Kopytova, Elena S. Yarkova, Sophia V. Pavlova, Diana A. Sorogina, Anastasia A. Malakhova et al.
    International Journal of Molecular Sciences
  116. Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells.
    Authors: Ohlemacher SK, Iglesias CL, Sridhar A et al.
    Curr Protoc Stem Cell Biol
  117. Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis
    Authors: Yijie Geng, Bradley Feng
    Heliyon
  118. Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity
    Authors: Francesca Ciarpella, Raluca Georgiana Zamfir, Alessandra Campanelli, Elisa Ren, Giulia Pedrotti, Emanuela Bottani et al.
    iScience
  119. Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme
    Authors: Raymond Teck Ho Lee, Hiroki Nagai, Yukiko Nakaya, Guojun Sheng, Paul A. Trainor, James A. Weston et al.
    Development
  120. Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics
    Authors: Francis Aguisanda, Charles D. Yeh, Catherine Z. Chen, Rong Li, Jeanette Beers, Jizhong Zou et al.
    Orphanet Journal of Rare Diseases
  121. A new patient‐derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of alpha ‐dystroglycan
    Authors: Jihee Kim, Beatrice Lana, Silvia Torelli, David Ryan, Francesco Catapano, Pierpaolo Ala et al.
    EMBO reports
  122. High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures
    Authors: KT Minn, YC Fu, S He, S Dietmann, SC George, MA Anastasio, SA Morris, L Solnica-Kr
    Elife, 2020-11-18;9(0):.
  123. Location of transient ectodermal progenitor potential in mouse development
    Authors: Lingyu Li, Chang Liu, Steffen Biechele, Qingqing Zhu, Lu Song, Fredrik Lanner et al.
    Development
  124. Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population
    Authors: Patrick Walsh, Vincent Truong, Sushmita Nayak, Marietta Saldías Montivero, Walter C. Low, Ann M. Parr et al.
    Stem Cells
  125. Nervous System Regionalization Entails Axial Allocation before Neural Differentiation
    Authors: Vicki Metzis, Sebastian Steinhauser, Edvinas Pakanavicius, Mina Gouti, Despina Stamataki, Kenzo Ivanovitch et al.
    Cell
  126. Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells
    Authors: Fadi J. Najm, Anita Zaremba, Andrew V. Caprariello, Shreya Nayak, Eric C. Freundt, Peter C. Scacheri et al.
    Nature Methods
  127. Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation
    Authors: Juan Li, Luting Chen, Danping Li, Min Lu, Xiaolin Huang, Xiaohua Han et al.
    Neural Plasticity
  128. The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing
    Authors: Kim J, Muraoka M, Okada H et al.
    PLOS Genetics
  129. Generation of Vascularized Neural Organoids by Co-culturing with Mesodermal Progenitor Cells
    Authors: Philipp Wörsdörfer, Anna Rockel, Yvonne Alt, Anna Kern, Süleyman Ergün
    STAR Protocols
  130. Acquisition of neural fate by combination of BMP blockade and chromatin modification
    Authors: Agnes Lee Chen Ong, Toshiya Kokaji, Arisa Kishi, Yoshihiro Takihara, Takuma Shinozuka, Ren Shimamoto et al.
    iScience
  131. Process-based expansion and neural differentiation of human pluripotent stem cells for transplantation and disease modeling
    Authors: Alexander E. Stover, David J. Brick, Hubert E. Nethercott, Maria G. Banuelos, Lei Sun, Diane K. O'Dowd et al.
    Journal of Neuroscience Research
  132. Prospective separation and transcriptome analyses of cortical projection neurons and interneurons based on lineage tracing by Tbr2 (Eomes)-GFP/Dcx-mRFP reporters.
    Authors: Liu J, Wu X et al.
    Dev Neurobiol
  133. The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders
    Authors: Cheen Euong Ang, Qing Ma, Orly L Wapinski, ShengHua Fan, Ryan A Flynn, Qian Yi Lee et al.
    eLife
  134. Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration
    Authors: Fathi A, Mathivanan S, Kong L et al.
    Aging Cell
  135. Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
    Authors: Minghui Wang, Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode et al.
    Neuron
  136. Characterization of Hypothalamic MCH Neuron Development in a 3D Differentiation System of Mouse Embryonic Stem Cells
    Authors: Kodani Y, Kawata M, Suga H et al.
    eNeuro

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Human/Mouse/Rat SOX1 Antibody
By Ying Chen on 08/19/2019
Application: Immunocytochemistry/Immunofluorescence Sample Tested: neural stem cells derived from h9 Species: Human

Neural stem cells derived from H9 cells were fixed in 4% PFA for 15 minutes. The cells were incubated in the sox1 antibody at the concentration of 5ug/ml overnight at 4 degree, the followed with secondary antibody incubation at room temperature for 1hour.

Immunocytochemistry/Immunofluorescence Human/Mouse/Rat SOX1 Antibody AF3369
Human/Mouse/Rat SOX1 Antibody
By Anonymous on 03/21/2018
Application: Immunocytochemistry/Immunofluorescence Sample Tested: hESC-derived NSC Species: Human

SOX1 was detected human embryonic stem cells-derived neural stem cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 1 µg/mL for overnight at 4°C. Cells were stained using the Donkey anti-Goat IgG (H+L) Cross-Adsorbed, Alexa Fluor® 568 and counterstained with DAPI (blue).

Immunocytochemistry/Immunofluorescence Human/Mouse/Rat SOX1 Antibody AF3369
Human SOX1 Antibody
By Anonymous on 10/26/2015
Application: Immunocytochemistry/Immunofluorescence Sample Tested: human NSC Species: Human

Specificity: Specific
Sensitivity: Sensitive
Buffer: 1% BSA + 0.3% Triton X-100 in PBS
Dilution: 1/100

Immunocytochemistry/Immunofluorescence Human SOX1 Antibody AF3369
Human SOX1 Antibody
By Anonymous on 10/26/2015
Application: Immunocytochemistry/Immunofluorescence Sample Tested: human fibroblast and human neural stem cells Species: Human

Specificity: Specific
Sensitivity: Sensitive
Buffer: 1% BSA + 0.3% Triton X-100 in PBS
Dilution: 1/100

Immunocytochemistry/Immunofluorescence Human SOX1 Antibody AF3369